Corona Episode: Hydroxychloroquine, Politics, and the Media

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hydroxychloroquine covid19

It’s bizarre when politics enter medicine, especially when they enter into the debate over which treatments are best for COVID-19. No medical treatment on earth has become more politicalized in the last few weeks than the drug Hydroxychloroquine. So let’s try to push aside all of the red vs. blue stuff and see if doctors on the front-line should be using this drug or not.

Red, Blue, or Purple?

First, the novel coronavirus doesn’t know if you’re a Democrat, Republican, or Independent. It doesn’t care that you watch Fox News or MSNBC or read The Blaze or The Atlantic. If you’ve got the wrong genes or are the wrong age or have a preexisting condition, it will take you just the same long before you can vote in November. In addition, everyone is for more clinical trials until it’s a loved one who is dying from COVID and then it’s “pull out all the stops” Doc. I’ve had that conversation with families more times than I can count.

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What Is Hydroxychloroquine?

This is a drug called Plaquenil. It’s been around for decades and is a cheap generic drug first used for Malaria in 1955 and also more recently used to treat Rheumatoid Arthritis and Lupus patients. The generic version of the drug should run about $15 here. In Africa, to treat Malaria, it’s 8 cents a dose. Compare that to the expensive antiviral drugs being used now to treat COVID-19 that are thousands of dollars for a course of treatment.

The Trump Pump?

President Trump discussed Hydroxychloroquine a few weeks back as a possible treatment for COVID-19 that was showing good results. Since then the FDA has provided an Emergency Use Authorization (EUA) for the drug to treat the novel coronavirus (5). However, because this advice was uttered by the President, whether you love or hate the guy, it’s clear that the use of this drug for COVID patients has become political. That furor has lead to academics writing in the British Medical Journal to claim that there just isn’t enough evidence and attack the idea that this old and cheap drug should be used (6). In addition, Michigan like other states had threatened regulatory action against doctors using this drug for COVID-19 patients until that order was later rescinded (10).

Does This Stuff Work?

The answer is that we have some evidence. Viewing this as a physician and without politics, it sure looks interesting. In addition, not caring whether a pharma company will make big bucks off of COVID-19 or not, let’s review what we know.

A group of French doctors published a small uncontrolled trial looking at whether Hydroxychloroquine would work for coronavirus patients with early and mild disease (2). The study showed good clearance of the virus.

The same group has now conducted a similar trial on 1,061 mild COVID-19 patients who were treated for at least three days with Hydroxychloroquine and Azithromycin (HCQ-AZ) (1). This was a retrospective case review and not the gold standard randomized trial. The mean age of patients was 44 years old and 92% of the patients recovered by 10 days. 4% of the patients needed to go to the ICU and half a percent died. Fewer patients died when treated with HCQ-AZ versus other regimens. There were no serious side effects of the medications. Interestingly, poor outcomes were observed in patients who were on two different types of blood pressure medications. One of these I have reported on before, which are ACE inhibitors. However, the other medication, beta-blockers, was a surprise.

A small randomized controlled trial of 61 patients using Hydroxycholorquine was placed on a prepublication site by Chinese physicians just a few days ago (4). The results were impressive after 5 days of Hydroxychloroquine treatment (HCQ). There was a better resolution of high temperatures and cough in the HCQ group and more patients showed imaging findings of improved pneumonia. In addition, only those patients who didn’t get HCQ progressed to severe disease. There were two patients out of 31 who had mild adverse reactions to the drug.

The NIH has just begun a trial here in the US using Hydroxychloroquine (3). Hence, hopefully, we’ll have some data in the next 2 months or so. However, this trial won’t be completed when physicians on the front-line are treating the most COVID-19 patients.

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Why the Push Back by Academics?

While I get that more high-level research is always better than less, in a scenario like this one, to try to save lives, decisions about efficacy can ONLY be made by doctors on the frontlines. If they see that Hydroxycholorquine works, given a reasonable side effect profile versus doing nothing, they should be using it. Academics in Ivory Towers should NOT be driving this conversation. As a society, we can let the academics run the clinical trials and if those don’t pan out, then the frontline doctors can stop using it.

Why wouldn’t academics be on board here? One thought is that this is not something they’re used to doing these days, putting clinicians in the driver’s seat. The other is that you MUST realize that universities are big businesses and many will make big bucks by creating new drugs and therapies for COVID. Hence, in my opinion, there is a big inherent conflict of interest here.


This drug supply is now being managed by the Department of Health and Human Services (HHS) to make sure that enough is available for both COVID-19 and the other diseases for which it’s used (7).  For example, HHS recently received 30 million doses as a donation from the pharma company Sandoz to the national stockpile (8). Novartis is donating up to 130 million doses of Hydroxychloroquine (9).

The upshot? While the data on using Hydroxychloroquine is NOT perfect, if I were a physician treating these patients in the hospital, I wouldn’t hesitate to use it in a high-risk patient. Hence, it makes no medical sense that there’s been such a media uproar about this drug. Again, the novel coronavirus doesn’t care how you vote, it’s just looking for a way to make more of itself, which is how viruses work. Republicans or Democrats are equally good viral hosts.




(2) Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial [published online ahead of print, 2020 Mar 20]. Int J Antimicrob Agents. 2020;105949. doi:10.1016/j.ijantimicag.2020.105949

(3) The National Institutes of Health. NIH clinical trial of hydroxychloroquine, a potential therapy for COVID-19, begins. Accessed 4/12/20.

(4) Chen Z, Hu J, Zhang Z, et al. Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial. Version 2. medRxiv 2020.03.22.20040758. [Preprint.] doi: 10.1101/2020.03.22.20040758

(5) Lenzer J. Covid-19: US gives emergency approval to hydroxychloroquine despite lack of evidence. BMJ2020;369:m1335. doi: 10.1136/bmj.m1335 pmid:32238355

(6) Ferner RE, Aronson JK. Chloroquine and hydroxychloroquine in covid-19. BMJ. 2020 Apr 8;369:m1432. doi: 10.1136/bmj.m1432.

(7) Arthritis Foundation. Hydroxychloroquine (Plaquenil) Shortage Causing Concern. Accessed 4/12/20.

(8) Department of Health and Human Services. HHS accepts donations of medicine to Strategic National Stockpile as possible treatments for COVID-19 patients. 4/12/20.

(9) Novartis. Novartis commits to donate up to 130 million doses of hydroxychloroquine to support the global COVID-19 pandemic response. Accessed 4/12/20.

(10) Detroit Metro Times. Gov. Whitmer reverses course on coronavirus drugs, is now asking feds for hydroxychloroquine and chloroquine. Accessed 4/13/20.

This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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11 thoughts on “Corona Episode: Hydroxychloroquine, Politics, and the Media

  1. Edith(Edy) Johnson

    Thanks for sharing this information.

  2. Douglas Kunce

    Early Chloroquine use appears to be key.

  3. Barbara

    How many patients have died and suffered, not just because of Covid-19, but because of similar over regulation and interference from bench scientists, the media, Big Pharma, etc., when it comes to trying experimental and off label use of drugs as well as our own stem cells administered by competent medical doctors? This situation is all too familiar. I can only shake my head and wonder how we got to caring more about politics and profit more than patients. Good article as always, Chris.

  4. Russ

    I believe some of the people who are counted as dying from Covid-19 really died from something else. That is nothing new. I also believe some of the people who supposedly died of the Flu over the years actually died of pneumonia. I believe the data quantifying Covid-19 deaths and the Flu are flawed and cannot be relied on 100%. Look for conflicts of interest. I don’t think I’m the only one that has that opinion. Big pharma would love you to think all these people are dying of Covid-19 and the Flu because they stand to make billions selling you a vaccine.That’s why the malaria drug is always disrespected, not necessarily because it doesn’t work but because the profit margin is very small and they will make very little compared to a vaccine, especially if most of the world’s population is required to get it. The major TV channels get up to 70% of their revenue from drug advertisements. They wouldn’t dare bite the hand that feeds them. Byrx and Fauci who are on Trumps’s Corona-19 task force are big proponents of vaccines and have been working in that industry for decades if you look at their bio. I believe all their public statements reveal they are trying to get the public to believe the best thing all of us can hope for is the vaccine. The also keep mentioning the virus will be here in the future which also implies we need to focus on prevention through vaccines.

  5. Stacey Kaufman

    I like to read about western and functional medicine, (ergo Regenexx instead of surgery). I’ve read that ventilators can cause a cytokine storm in the lungs, and that taking a good quality multi vitamin, vitamin D3 with K2, zinc and vitamin C is crucial. I’ve also read/seen naturopaths saying if you must be hospitalized for COVID, you should get high dose IV vitamin C, but no ventilator. How do you know who to believe?🥴

    1. Chris Centeno, MD Post author

      Stacey, Naturopaths are NOT trained in this type of acute ICU medicine. They train on the worried well and NOT the seriously ill in ICUs. So while taking supplements may help, these patients go down hard and fast. Their intubation, unlike many other types of patients with respiratory illness is NOT planned, it’s an emergent shit show. Meaning, you either intubate them successfully in 5 minutes or less or they die. I saw the same video you watched. That naturopath had no sense of which end is up when it comes to what’s going on with these severe COVID-19 patients.

  6. don m

    Great evaluation Dr. Good old common sense always prevails. Those who took care of their lungs (eg. exercise, aerobics, not smoking etc) will survive; unfortunately it will be tough for the others.

    1. Chris Centeno, MD Post author

      While I think that probably helps, we’ve had plenty of young athletes die, so there’s something else at play here…

  7. Rebecca Kiefer

    I agree completely. I’m tired of having politicians with no medical knowledge driving the train. If I get the virus I would hope that my doctor would use whatever is at his disposal that might help rather than wait for something proven long after I died.

  8. Jill

    Just like with AIDS, they wouldn’t approve many drugs until they were proven, and in the meantime, how many people died from it? Also, as far as cytokine storms and the sudden rapid decline of ICU patients, a Dr. Tom Yadegar is successfully using strong immuno-suppressant drugs (yes counter-intuitive) to save patients lives. Yet I still hear doctors talk about the sudden rapid declines and that they don’t know what to do about them. They could try this! If I get the virus, I will print this article and take it with me to the hospital!

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