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Alternatives to Knee Replacement Surgery for Osteoarthritis

Knee osteoarthritis (OA) is one of the most common orthopedic conditions. If you are experiencing OA, you understand the pain and discomfort involved and how it can negatively impact your quality of life and enjoyment of daily activities.

Historically, many patients over 40 with knee pain due to osteoarthritis (commonly referred to as arthritis) have been advised to try physical therapy, nonsteroidal anti-inflammatory medications (NSAIDs), hyaluronate or corticosteroid injections to reduce inflammation and pain. If these are not helpful, the next recommendation is often arthroscopic knee surgery to repair or remove any damaged cartilage or tissue that may be causing the pain. If the surgery doesn’t deliver the desired results, then total knee joint replacement is usually recommended.

Alternative to knee replacement surgery for osteoarthritis

Numerous studies2 evaluating the results of common orthopedic knee surgeries have shown that these procedures generally don’t work unless the patient is younger than 40 years of age. Even then, successful outcomes are not guaranteed. If this is new information to you, you are not alone. A lot of people don’t know that surgery isn’t always the solution. Read on to learn more about our regenerative medicine alternatives to knee replacement surgery for osteoarthritis.

Woman in telemedicine consult with physician to see if she's a candidate for Regenexx for knee osteoarthritis.

Regenexx procedures are non-surgical treatments that use your body’s own healing agents to treat knee arthritis and injuries. Our patients benefit from reduced pain and improved function, helping them avoid surgery and knee replacement.

Am I a candidate?

Our stem cell protocol is supported by more than a decade of experience, published research, and patient outcomes. We maintain an active national patient registry to track patients’ progress or side effects post-procedure. On average, Regenexx knee osteoarthritis patients report:

  • A 47% decrease in joint pain after one month3
  • Regaining up to 75% optimal function4 
  • That their joints feel 37% better after one month5

*View full outcomes here.

Below are the outcomes of two patients who had Regenexx procedures done for knee osteoarthritis. Scroll the arrow to the right to see the MRI of the knee joint before the Regenexx treatment — the white/ lighter area indicates damage. Scroll to the left to see the MRI of the knee joint after the Regenexx treatment.

Patient 1 MRI: 51 years old

Patient 2 MRI: 46 years old

Patient 1: The patient was unable to return to many activities after unsuccessful microfracture surgery. As a result, underwent percutaneous, autologous, mesenchymal stem cell implant, after which they were able to return to their daily activities.

Patient 2: The patient had unsuccessful arthroscopic debridement surgery, where a large 3 cm. by 4 cm. osteochondral defect on the medial femur was discovered. The patient was then treated with percutaneously implanted autologous mesenchymal stem cells 1.5 years after surgery. The patient was able to return to full functional activities.

Regenexx Webinar

How stem cell and PRP procedures can help treat your knee arthritis injury.

Join Chris Centeno, M.D., founder of Regenexx, to learn about how Regenexx stem cell and platelet procedures can treat your knee arthritis injury.

Register for the webinar
Visual representation of regenerative medicine

The Knee Owner’s Manual

How to Avoid Game Changing, Invasive Knee Surgeries and Stay Active as You Age

Get a free copy of The Knee Owner’s Manual and learn the best way to stay active as you age.

Download your copy
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9035 Wadsworth Pkwy #1000
Westminster, CO 80021


*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.