Dural Leak Treatment: Harry’s Story…

By /

dural leak treatment

Most patients are unaware that there’s fluid around their brain, spinal cord, and nerve roots that literally floats their whole neurologic system. They also don’t realize that the system designed to hold it all can spring a leak and that when it does, all heck can break loose. While we’ve treated many patients with dural leaks through the years, one in particular stands out as a happenstance of being in the right place at the right time—a 16-year-old named Harry. His case is a great way to shed some light on dural leak treatment.

What Is the Dura?

Your nervous system is made up of your brain, the spinal cord, and the spinal nerves that leave the spine. There are also peripheral nerves that go to and from various parts of the body and a few other parts and pieces, but our focus today is on the central nervous system. To protect these fragile structures, your brain and spinal cord live inside strong bones (the skull and vertebrae).

Your body has a problem, and its solution dictates why dural leaks happen. The nerves and brain are sensitive structures that can be easily damaged. In addition, if you put any pressure on the nerves, they will fire off, giving a false signal, like a wire that’s short-circuiting. To get around this, nature has enclosed all of the nerves into a sheath called the dura. It’s kind of like a specialized water balloon that allows your brain, spinal cord, and nerves to float in liquid (called cerebrospinal fluid, or CSF). This provides excellent protection as well as shock absorption.

Request a Regenexx Appointment

What Is a Dural Leak?

As you might imagine, at the end of the day, no system of containment is perfect. If you place enough pressure on even the world’s best water balloon it can pop or spring a leak. In addition, if you poke a hole in it or if it was manufactured with a weak spot, the same thing can happen. The body is the same. The containment system of the CSF, called the dura, can also spring a leak. When it does, the fluid can leak out and the brain, spinal cord, and nerves can lose their containment system.

What’s unique about your personal water-balloon nerve-flotation system is that it’s constantly topping off the system. To do this, your body makes CSF at a certain rate. If you spring a small leak, the body can handle that by simply ramping up the production of the fluid. However, if the volume per unit time of the leak exceeds the body’s ability to replace the fluid, then you get “low in the tank,” causing your brain to literally bang into the skull—talk about a headache!

What Are Dural Leak Symptoms?

Imagine an ice cream headache on steroids and multiply that by 20—that’s what many patients with dural leaks experience. In addition, they can have a bevy of other nerve-type complaints because their spinal cord and nerves are being stretched. This can include confusion, disorientation, numbness or tingling, or pain referring to strange places. Given the vague nature of the complaints, it’s not hard to see why these patients get lost in the medical care system. However there is one symptom that’s pretty specific to dural leak patients. They’re better when lying flat, and it all gets worse when they’re upright.

What Causes Dural Leaks?

The biggest cause is iatrogenic, which is a fancy medical way of saying that we doctors are the culprit. Some happen as a result of epidural injections that inadvertently puncture the dura. Some happen because of spinal taps, where the goal is to puncture the dura. Some can also occur in car crashes where sudden pressure builds up in the CSF, causing a dural blowout. Finally some just happen (spontaneous), likely due to a pre-existing defect in the dura (a weak spot).

Join us for a free Regenexx webinar

What Is a Dural Leak Treatment?

As silly as it sounds, the treatment for dural leak is as simple as “patch the hole”! Sometimes patients get offered a surgical repair, but that can be difficult if there are many holes to patch. In addition, finding where the leak is occurring in the first place can be maddeningly difficult as few tests exist to accurately show where the leak is located.

The old reliable dural leak treatment is called a blood patch. This is what it sounds like—injecting the patient’s whole blood into the area around the dura (epidural) and allowing this to coagulate to seal the hole. The advantage of a blood patch is that you can inject several epidural sites and cover a whole area at a time, like the lumbar (low back) spine. If that doesn’t work, you can march up to the lower thoracic, then upper thoracic, and then cervical. By process of elimination, you can thus find the region of the leak.

Some chronic dural leakers are also injected with fibrin glue, which is a newer dural leak treatment. This is the same stuff used to close skin wounds in the emergency room. It can be easily injected, and then it sets up with a rubber-cement-like consistency. We’ve heard mixed results from our dural leaker patients as some report that it can cause scarring of the dura, and at least one poor woman got hepatitis from a poorly screened human donor of the fibrin.

We’ve been blessed in this area with a natural dural leak treatment for many of these patients—platelet lysate (PL). We routinely inject epidural growth factors isolated from blood platelets to help patients with things like herniated discs. However, that same injectate turns out to be a great dural leak treatment as it can be easily polymerized to form what looks like a blood clot by injecting a little activation agent right after the PL. It also has a natural growth-factor cocktail to assist in healing the hole in the dura.

Harry’s Story

It’s always tougher for a physician when medicine gets personal. One of the boys my son has known since he was in first grade is Harry, a great kid who has since turned into a fine young man (funny to write it that way as I thought I would never get old enough to write that statement!)

One evening I got a text that Harry was in the ER. After a lacrosse practice, he suddenly got confused, had a severe headache, and couldn’t focus his eyes. The work-up to rule out bad things that can quickly kill you, like meningitis, was negative, but to be 100% sure, a spinal tap was done, which took a few tries. This procedure involves puncturing a hole in the dura to see if there’s an infection in the CSF. Regrettably, this turned out to be the 180-degree opposite of what was needed to help poor Harry.

Over the ensuing days, Harry was bedridden, feeling fine when he was lying down but getting a massive headache, confusion, and visual issues when he got up for more than a few minutes. My first reflex was to tell his parents to take him to see a neurologist, but then it hit me—I knew this diagnosis. After some more Q and A, Harry had the one symptom that almost always ID’s a dural leak: the fact that everything gets much worse within just a few minutes of being upright. Even though I couldn’t figure out why an otherwise healthy young kid would spring a leak (other than the hole in his dura created by the spinal tap), I knew all about dural leak treatment! Time for a blood patch!

I started with patching his lumbar and sacral spine as this is where most dural leakers spring a leak because this area is under the most pressure. The first patch was great, in that he was able to almost immediately feel better, but it didn’t last. It then struck me that I needed to find the exact site where the ER physician had performed his spinal tap as that was likely to be the biggest hole. By focusing on that area for the second blood patch, the second procedure cured the issue. He was literally taken from bedridden to wanting to go back to lacrosse within a day or two (we held him out for a week to give the hole in the dura more time to heal).

One of the things I want to highlight with Harry’s story is that one of the more awful things that dural leakers experience is the medical-specialist shuffle. Harry’s case was unique as he happened to be in the right place at the right time. However, most of these poor patients bounce around from one specialist to another for months or years, living in agony until someone identifies what they have. In addition, finding physicians who will perform the multisite epidurals needed to ID the spot and who will march up the spine from the sacrum to the neck if needed is tough.

The upshot? Dural leaks are a very real problem with a quick fix as long as the issue is identified early. Chronic dural leakers have a tough row to hoe, as they get bounced around from doctor to doctor. We’ve had great success in using a modfied version of our platelet lysate technique to help these patients. In the end, while it’s tough when medicine gets personal, it’s equally fun when I can save a young kid from months of misery and getting bounced from specialist to specialist!

This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

Get Blog Updates by Email

By submitting the form, you are agreeing that you read and consent to our Privacy Policy. We may also contact you via email, phone, and other electronic means to communicate information about our products and services. We do not sell, or share your information to third party vendors.

Category: Latest News

Leave a Reply

Your email address will not be published. Required fields are marked *

12 thoughts on “Dural Leak Treatment: Harry’s Story…

  1. Allison Suddard

    Dr Centeno,
    You diagnosed me with dural tears after a car accident. I had Kaiser insurance at the time and they neither believed you nor wanted to treat it. After 5 years in the Kaiser system I finally got out and came back to you. You did a full spine blood patch in and the burning spinal pain and headaches are finally gone. All-in-all it was 6 very long years of daily pain. Thank you for all you do!
    Allison S.

  2. Chris Centeno Post author

    Thanks Allison! Yep, car crashes seem to be a significant cause of these leaks…

  3. dom Costabile

    Thanks for sharing this interesting clinical issue. What volume of platelet lysate due you use for this indication? Have you found it necessary to use a blood patch after the platelet lysate? appreciate your sharing this vignette.

    1. Regenexx Team Post author

      Volumes are as high as possible at each level to cover the largest possible area-generally 5-10 cc injected transforaminal under fluoro (not an ultrasound only procedure). So to cover lumbosacral-caudal, pus L4-L5 TF, plus L2-L3 TF, plus T12-L1 TF-but levels performed depend on how the contrast flow looks under fluoro. For example, if more coverage less injections, if less coverage more injections. The PL will activate in most patients when it hits the epidural space, but if there’s a concern, CaCl2 added after injection will help it coagulate, so no need for a blood patch in that situation.

  4. Colleen


    I got my leak from a spinal with my 3rd c-section. My symptoms presented in a way that my headpain got worse over a 6 month period. My leak was only identified they exploratory surgery almost 1 year later. I have had 7 failed bp, and 2 failed surgery. With each I started to feel better then quickly got bedridden it has been 2 1/2 years and I have run out of options. Have you treated long term leakers who have have not gotten a permenant fix with surgery? And have you seen stem cells work well? What is the success rate? How many patients have been fixed. Thank you so very much, Colleen

    1. Regenexx Team Post author


      Yes we have. This blog goes all the way back to 2011: https://regenexx.com/blog/round-2-stem-cells-and-a-chronic-dural-leaker/ If you’d like one of our physicians to review your case to see if you’d be a Candidate, please submit the Candidate form.

  5. Yasmin Joseph


    I am in desperate need of help. I had a lumbar puncture performed 12/22/18 which yielded negative results. A spinal headache started 24 hrs later. I have had 3 low volume blood patches. The second patch worked but blew after sitting down. I am quick going downhill since my last patch. Do you still perform blood patches as mentioned in this article? Any information will be greatly appreciated. Thank you

    1. Regenexx Team

      Hi Yasmin,
      Where are you located?

  6. Shronda

    Since April 2019, I been very sick. Severe headaches every time I sit or stand, nausea, neck and shoulder pain, blurry vision, ear pain, racing heart every time I stand, and dizziness. Also every time I sit up or stand I cannot focus or concentrate at all. I’m still waiting to go see a neurologist. However, I had a spinal tap done a few weeks ago and started having severe headaches to the point I couldn’t even lift my head up. I went to the ER and they did a blood patch. After a couple of days the headache went away but when I lay down I get some pressure in my head and I still have nausea. Also, I am still experiencing problems concentrating and focusing when sitting and standing and my heart is still racing every time I stand. Can you please tell me how long does it take before all these symptoms go away?

    1. Regenexx Team

      Hi Shronda,
      Please seek the advice of the Physician who treated you. Once they’re satisfied that your CSF leak is stabilized, if you still have symptoms, it would be important to look into what else may be causing them. Upper cervical issues would be one area to explore. Please see: https://regenexx.com/blog/craniocervical-instability-measurements/

  7. Donna Oriordan

    My daughter has had four surgeries in the past 6 months to try and repair spontaneous csf leaks. The last one was intercrainial(and did not work). The doctors said she has a thin dura. So it appears that they repair one hole and then another one opens. She is in California, but we are bringing her to New York so that her family can help care for her and her three kids. Since she is completely debilitated. Is there anyone in the New York area you can recommend? She is a military wife with military insurance. Any help would be appreciated.
    Thank you,

    1. Chris Centeno, MD Post author

      You may want to look up Dr. Robert Kramberg on our network who is in NJ and Manhattan

Is Regenexx Right For You?

Request a free Regenexx Info Packet


Learn about the #1 Stem Cell & Platelet Procedures for treating arthritis, common joint injuries & spine pain.

Join a Webinar


Get fresh updates and insights from Regenexx delivered straight to your inbox.

Subscribe to the Blog


9035 Wadsworth Pkwy #1000
Westminster, CO 80021


Copyright © Regenexx 2021. All rights reserved. | Privacy Policy

*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.