My Top 10 Posts of 2015!

by Chris Centeno, MD /

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regenexx 2015 top 10 blogs

Now that 2015 is coming to a close, I thought I’d pick out my top 10 favorite blogs. In fact this year, I have three top 10 lists. Next will come the top 10 most read Regenexx blogs of this year and then the top 10 that generated the most social media buzz. So let’s begin!

My favorite blogs are usually the ones I felt the most passionate about. I write almost everyday, and many times the topics that I chose are based on what I’ve seen in the clinic that week. I also research the US National Library of Medicine often, so when I come across a research paper that seems interesting, I turn it into a blog post. I also have a network physician (Rob Kramberg, M.D.) who sends me studies that might be interesting to post, so much thanks to Rob! Finally, sometimes I just update readers about the latest and greatest happenings at Regenexx.

Here’s my top 10 list (not in order):

Can a Precise Regenexx Stem Cell Injection into a Shattered Shoulder Humerus Bone Work where Surgery Couldn’t?-Why do I love this post? My life’s work is continuing to prove that while traditional orthopedic surgery has earned a great place in medical history, it’s also time for much of it to be replaced with less invasive procedures. In this case, a woman with a shattered humerus bone and avascular necrosis was told by many surgeons that they wouldn’t touch her problem with a 10 foot pole. However, a precise fluoroscopically guided injection of her own stem cells prepared using our advanced techniques helped heal most of her bone! There were countless cases just like this one this year. Patients who had little hope for recovery using traditional orthopedic surgery techniques who reported great results and/or had big changes in their imaging after a Regenexx procedure.

Our New Interventional Orthopedics Fellowship Stem cell Training Programs-If one aspect of my life’s work is perfecting the use of stem cells and platelets to heal or manage orthopedic problems through precise injection, the nest part is teaching these advanced techniques to appropriately skilled physicians. This is really not happening out there right now, as any doctor with a heartbeat and a driver’s license is being trained to poorly inject stem cells by for profit outfits often by physicians who barely know more about the topic than their students. Our new 3 month Interventional Orthopedic mini-fellowships allow physicians who already have advanced injection skills to integrate precise stem cell procedures into their practices. These physicians have about 100 separate procedures to master, so if the weekend existing stem cell courses are like the certificate degree mills on-line, our program is the Harvard or Princeton of musculoskeletal stem cell education.

Mesenchymal Stem Cell Research Publishing Volume Decimates Embryonic Stem Cell Research-When the stem cell craze first began in the late 90s, it was almost all focused on embryonic stem cells (ESCs). How this tissue was being sourced (i.e. from aborted fetuses) angered many, so science began to research a new type of stem cell obtained from your body that went by the moniker of “mesenchymal stem cells” (MSCs).  A few years back, a strange thing happened, the volume of MSC research surpassed ESC research. This year the trend not only continued, but it accelerated! The ESC king is dead, long live the MSC king!

My Lecture at Walter Reed and the Uniformed Services University-Most people don’t know that because my brother had attended the Naval Academy, I almost went to Vanderbilt on a Navy ROTC scholarship. There was one little complication however, I failed a color blindness test. Turns out that you have to be qualified upfront for every job in the Navy , including flight surgeon. So being able to give back to the military was a great honor this year, as I was invited to give a stem cell course to Army, Navy, Marine, and Air Force physicians at the Uniformed Services University located at Walter Reed.

-Regenexx Publishes the Largest Knee Arthritis Stem cell Study to Date-One of my focuses has always been publishing our meticulously collected data from our treatment registry. Our knee arthritis stem cell paper using the Regenexx-SD patented protocol is the largest of it’s kind, with the next biggest stem cell paper in this area reporting on about 10 times fewer patients than our publication.

-My Video on Stem Cells From Fat vs. Bone Marrow-This is always a hot topic-does fat or bone marrow have more stem cells? What fascinating is that the fat stem cell advocates have been using a 5th grade math error to justify their view that fat has many more stem cells. This video explains the math error and shows that bone marrow in many ways, is a far richer source of stem cells than fat.

-My Summary of the Many Research Papers Published on the Use of Bone Marrow Stem Cells for Orthopedic Injuries and Diseases-What’s amazing is that in 2015, we still hear many advocates of mass produced stem cell drugs scream from the roof tops that we don’t yet have enough research. Despite these protestations, when you add up all of the research on bone marrow stem cells used for orthopedic problems going back to 1997, more than five thousand patients have been treated and had their results published in peer reviewed medical journals. We’re also proud to note that about 1/3 of those patients are our patients who were treated with our patented protocol!

-Our Research on Healing Knee ACL Tears with Precise Stem cell Injections-There is no orthopedic injury that for me better represents the future than ACL tears. This is traditional orthopedic surgery bread and butter, cutting out a damaged ligament, drilling big holes in the bone, and installing a tendon and hoping it stabilizes the knee as well as the original equipment. However, we’ve seen evidence that using our precise injection technique under fluoroscopic guidance can replace the need for surgery in about 70% of patients who currently get surgery. This is our first research paper to begin to prove that point with a second one to follow soon!

-Our Shoulder Stem Cell Precise Injection Paper is Published-Another area that represents the less invasive future of orthopedics is rotator cuff tears. Again, we’ve seen good observational evidence that about 70% of patients who currently end up with invasive surgery for rotator cuff tears can skip the surgery and instead get a precise injection of stem cells into the tear to promote healing. This paper is our first publication to begin to prove this point.

-My Video on How Most Doctors Performing Stem Cell Injections are Screwing up the Bone Marrow Harvest Procedure-As discussed above, if you see a physician who proclaims they know how to perform stem cell injections, chances are he or she took one of the “schlock” weekend courses described above. In addition, this doctor likely also never learned how to properly draw bone marrow to maximize the number of stem cells. For example, some uneducated physician teaching the course likely told him or her that the best way to do this is to draw a single site. This is despite the fact that we’ve know for many years that this is not the best way to get the most stem cells. This video tries to educate physicians about how to do this right. How can you make sure your doctor knows the correct technique? Find a Regenexx provider near you!

The upshot? At the end of the day, my top 10 list are the blogs I felt the most passionate about. Later this week, we’ll look at the ones you loved the most either by page views or social media engagement. Here’s to a fantastic 2016!

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20 thoughts on “My Top 10 Posts of 2015!

  1. Veruska

    How successful have you been with tendon tear on outer thigh?

    1. Regenexx Team

      The issue with thigh tendons is getting your lower back checked out, as many of these issues originate there. Different tendon, but same idea: We’ve been successful in both treating the tears and the cause.

  2. Dennis

    What is your experience and thoughts on Stem Cell injection for a large Chondral defect of the Talus diagnosed as Osteochondral Dissacans? I have been fighting this for several years and the psi is getting unbearable with my active life style. Thoughts????

    1. Regenexx Team

      We regularly treat necrotic issues. Osteochondral Dissecans doesn’t heal on its own, it gets worse, and surgery complicates the situation greatly, so the important thing would be to get it treated.

  3. Len

    Do you have any experience treating clavicle osteolysis?

    1. Regenexx Team

      I will inquire…

    2. Regenexx Team

      What caused the Clavicle Osteolysis?

  4. Jean

    After lots of research and checking out the many places in Florida that does the stem cell therapy, we kept going back to the Regenexx site. After a webinar with Dr. Centeno we decided to go to Bradenton East Integrative Medicine and my husband met with Dr. Amoroso and his son, Evan. Gary needed TKR on both knees, didn’t want surgery and so we decided to go with the stem cell therapy. Gary wanted both knees done at the same time but we were advised not to do so because his knees were both so bad it was better to do one at a time. He had his right knee done in November. We are now hitting the 5 week period and I just can’t explain to you how much better his right knee is doing. We have so many people watching him, even his therapist was so excited to get a patient like Gary so he could check it out first hand, plus many who tried to discourage him from doing something that wasn’t covered by insurance. He is feeling pain but it has gone from 10+ to maybe 4 or 5 in only 5 weeks. It is a little scary, he keeps expecting the full pain to come back. Please tell us that isn’t so, that he should stay the same or only get better in the months to come. Dr. Amoroso and his son, Evan were great, so helpful with the many, many questions and emails, before -during- and after the procedure. Gary is ready to do the left knee, but we have to wait a few more months!!

    1. Regenexx Team

      That is wonderful news, thank you so much for sharing it with us! It is why we do what we do. Please tell Gary not to worry, he should get better in the months to come. Please keep us updated throughout Gary’s journey.

  5. sandi

    Have you successfully treated bone-on-bone hip arthritis? I have no cartilage, bone spurs and a bone cyst. Could this therapy help?

    1. Regenexx Team

      Yes. Bone spurs are caused by your body’s attempt to stabilize an unstable joint, so it’s very important to determine what caused your hip to be unstable, and treat that issue, especially since that same instability contributes to arthritis.

  6. Ruth Rosines

    Do you have evidence that using stem cells to help maintain or thicken hip joint cartridge ,
    Is working? Assuming there is thinning of cartridge due to arthritic changes.

    1. Regenexx Team

      We treat Hip Arthritis routinely, and cartilage benefits from stem cells. The more important thing to understand though is that thinning cartilage is rarely the source of pain, so the more important issue is to figure out what is actually causing the pain: If your cartilage is thinning due to arthritis, this contains important information about the mechanism of cartilage loss, and what you can do about it:

  7. Kat

    What is your success with treating hip labrum tears and hip bursitis?

  8. Beverly

    My son had a crush injury to his foot in March, 2015 (12 fractures, major soft tissue injury due to the extreme weight). He will have his 3rd surgery in 2 weeks to get some plates out. His Ortho MD says the MRI would be better after he heals for a while, but agreed to order an MRI for your review.

    Do you work on trauma patients who are trying to regenerate the nerves, tendons, ligaments, muscle, etc., in addition to the bones and joints?

    Is there a ‘trauma’ specialist on your team of Regenexx providers? If so, what location?

    1. Regenexx Team

      Yes, we treat injuries of the nerves, tendons, ligaments, tendons, and non healing fractures. While we appreciate your desire to get this evaluated before the upcoming surgery, in this case we agree with his Ortho, in that evaluation would likely be better placed once the plates that will be removed are out. We don’t have a “trauma” specialist on our team as we don’t do surgery; our job here would be to sort through the remaining issues after the required surgeries. Once he is ready for evaluation, please use our main office 888 525 3005 to schedule the appointment so that they can set you up with the Provider with the necessary skillset closest to you.

  9. Beverly

    OK, thank you for your reply. We are anxiously waiting!

  10. Florence

    I liarltley jumped out of my chair and danced after reading this!

    1. Regenexx Team

      Hopefully it was a happy dance! Thank you!

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
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Regenerative procedures are commonly used to treat musculoskelatal trauma, overuse injuries, and degenerative issues, including failed surgeries.
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Many Shoulder and Rotator Cuff injuries are good candidates for regenerative treatments. Before considering shoulder arthroscopy or shoulder replacement, consider an evaluation of your condition with a regenerative treatment specialist.

  • Rotator Cuff Tears and Tendinitis
  • Shoulder Instability
  • SLAP Tear / Labral Tears
  • Shoulder Arthritis
  • Other Degenerative Conditions & Overuse Injuries
Learn More
Cervical Spine


Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More


Knees are the target of many common sports injuries. Sadly, they are also the target of a number of surgeries that research has frequently shown to be ineffective or minimally effective. Knee arthritis can also be a common cause for aging athletes to abandon the sports and activities they love. Regenerative procedures can be used to treat a wide range of knee injuries and conditions. They can even be used to reduce pain and delay knee replacement for more severe arthritis.

  • Knee Meniscus Tears
  • Knee ACL Tears
  • Knee Instability
  • Knee Osteoarthritis
  • Other Knee Ligaments / Tendons & Overuse Injuries
  • And more
Learn More
Lower Spine


Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Hand & Wrist

Hand & Wrist

Hand and wrist injuries and arthritis, carpal tunnel syndrome, and conditions relating to overuse of the thumb, are good candidates for regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Hand and Wrist Arthritis
  • Carpal Tunnel Syndrome
  • Trigger Finger
  • Thumb Arthritis (Basal Joint, CMC, Gamer’s Thumb, Texting Thumb)
  • Other conditions that cause pain
Learn More


Most injuries of the elbow’s tendons and ligaments, as well as arthritis, can be treated non-surgically with regenerative procedures.

  • Golfer’s elbow & Tennis elbow
  • Arthritis
  • Ulnar collateral ligament wear (common in baseball pitchers)
  • And more
Learn More


Hip injuries and degenerative conditions become more common with age. Do to the nature of the joint, it’s not quite as easy to injure as a knee, but it can take a beating and pain often develops over time. Whether a hip condition is acute or degenerative, regenerative procedures can help reduce pain and may help heal injured tissue, without the complications of invasive surgical hip procedures.

  • Labral Tear
  • Hip Arthritis
  • Hip Bursitis
  • Hip Sprain, Tendonitis or Inflammation
  • Hip Instability
Learn More
Foot & Ankle

Foot & Ankle

Foot and ankle injuries are common in athletes. These injuries can often benefit from non-surgical regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Ankle Arthritis
  • Plantar fasciitis
  • Ligament sprains or tears
  • Other conditions that cause pain
Learn More

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