Who Needs IPS Cells: Old Cells made Young Again by Simple Exposure to the Stuff of Youth

By /

I’ve been a big critic of IPS (induced pluripotent stem cells), as the concept seems to represent a solution without a problem cooked up not by clinicians, but by business models. To review, IPS is the lab process of taking a regular old cell like a skin cell and exposing it to substances or genes that make it revert back to a stem cell. The unintended consequences scale couldn’t be more magnified, a bit like playing with matches at a gas station. The problem is that we understand this process about as well as we understand the body at a genetic level-meaning we’re in Kindergarten and it’s before recess. Case in point that illustrates why IPS isn’t needed is a recent study out of University of Texas, showing that old mesenchymal stem cells (MSC’s) reproduce and make bone like young cells when they’re exposed to young extracellular matrix (ECM). ECM is the goo that cells produce to live in, a bit like a bird building a nest. The researchers figured out that old MSC’s lost some of their ability to grow quickly in culture and weren’t as good at making new bone as young cells. However, by simply exposing the old cells to young ECM, the old cells grew and repaired bone like young cells. The authors theorized that it’s actually the old ECM that tells old MSC’s to be old and not some internal property of the cells themselves. So here’s a very simple solution to dealing with older patients and trying to get their stem cells to behave like young stem cells without tricking skin cells to become stem cells. Or you can teach a old cell new tricks!

Join us for a free Regenexx webinar.
Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications. View Profile

If you have questions or comments about this blog post, please email us at [email protected]

NOTE: This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

Get Blog Updates by Email

We do not sell, or share your information to third party vendors.

By submitting the form you agree that you’ve read and consent to our Privacy Policy. We may use email, phone, or other electronic means to communicate information about Regenexx.

We will provide information to help you decide whether you want to schedule an evaluation with a Regenexx Physician.

Insurance typically covers evaluations and diagnostic testing (if recommended). Most insurance plans currently do not cover Regenexx Procedures.

Category: Latest News
Copyright © Regenexx 2021. All rights reserved.



9035 Wadsworth Pkwy #1000
Westminster, CO 80021


*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.