Nerve Regeneration – The Future Doesn’t Involve Surgery

By Chris Centeno, MD /

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nerve regeneration

Regenexx first began treating injured nerves using orthobiologics delivered via ultrasound guidance in 2012. However, the concept that a precise injection can help nerve regeneration was so revolutionary that we were reluctant to really shout it from the roof tops until we had enough experience under our belt to be sure that it was working. After a few years of seeing nerve injury patients consistently respond to this therapy, I think it’s time to share some of our results and finally declare our confidence in this new procedure that may change how doctors treat nerve injury and entrapment, now and in the future.

Regenexx History with Nerve Regeneration

Our history with the nerve regeneration procedure begins with a different take on platelet rich plasma (PRP), which is the concentration of platelets from a blood sample. Unlike almost all clinics that use PRP, we’ve always had another platelet-based treatment available called platelet lysate (PL). Unlike PRP which can be pro-inflammatory, PL is anti-inflammatory. As industry leaders in regenerative medicine and related research, we’ve noted that this growth factor cocktail works particularly well around nerves. As a result, we’ve been using PL in the epidural (spinal column) space since around 2007 with great results, mostly for patients with sciatica (radiculopathy). As a result, our many successes with PL have driven us to perform the lab research necessary to create successively more powerful versions of PL (we’re currently on our 4th generation version).

What is PL and why is it so special? Platelet lysate is made up of the healing growth factors isolated from platelets and resuspended in a growth factor and cytokine rich serum. As discussed above, we’ve been perfecting how to make PL for many years, regularly increasing its growth factor content beyond the simple PLs we first used back in 2007 (which is essentially what some other doctors are just beginning to use).

How Can Platelet Lysate Injections Help Regenerate Nerves?

A critical part of the nerve regeneration procedure is precise ultrasound guided hydrodissection. This involves visualizing the nerve under ultrasound guidance and using a small needle to inject small volumes of PL around the nerve. Effectively, the doctor is breaking up scar tissue around various parts of the nerve and freeing it up. This can be critical, as many times nerve entrapments and trauma involve scarring around the nerve that compress the structure. Think of a garden hose and how the water flows through it. A nerve is a similar thing in that it transports nutrients down it’s length. If you step on the garden hose, less water comes out the end, just like a nerve that’s entrapped and scarred, with less nutrients making their way down the nerve. Hydrodissection is like releasing that pressure on the garden hose.

Outside of the mechanical effects of breaking up scar tissue, we believe the growth factors in PL can help nerve function. One of those natural compounds is called vascular endothelial growth factor or VEGF and is responsible for causing the body to create new blood vessels. Nerves have a blood supply like any other tissue and much of that lives on the outside of the nerve. When nerves have pressure placed on them, that blood supply can be cut off, reducing oxygen to the nerve. So creating new blood vessels around nerves may be important in nerve regeneration.

Why Patients Want to Avoid Nerve Surgery Whenever Possible

Surgery to get rid of nerve entrapment is generally not a good idea. I can’t tell you how many patients we’ve seen through the years who have gone through these surgeries with no results, or who have developed new problems related to the surgery. In fact, research has shown that one of the world’s most common nerve entrapment release surgeries, Carpal Tunnel Release, destabilizes the bones of the wrist, due to the surgery cutting a critical ligament that is required for wrist stability.

Trying to repair nerves by cutting them and splicing them back together with micro-surgery is notoriously difficult. Nerves are incredibly complex structures, so getting this surgery just right is hit or miss. This is why the better option is to free up some space around the nerve and give growth factors the opportunity to help the nerve accomplish it’s own regeneration.

Clinical Results Speak for Themselves

We’ve seen Regenexx Procedures time and time again get rid of carpal tunnel syndrome (entrapment of the median nerve at the wrist) without surgery. We’ve observed it help a patient regain radial nerve function. We’ve also witnessed it treat ulnar nerve encampments at the elbow, femoral nerve entrapment at the thigh, as well as tarsal tunnel at the ankle. All through a needle and without the need for invasive surgery.

Case in Point

To give you a better sense of how revolutionary this new procedure can be, I’d like to highlight a recent nerve regeneration patient treated by Dr. Pitts in our Colorado clinic. MS is a 57 year old male who presented to our clinic after a fall from a ladder, sustaining a fracture of his left humerus (upper arm bone). With this injury he also injured the radial nerve (nerve that gives signal to the muscle that causes wrist extension and sensation to the back of the hand). He had surgery to repair the fracture, but the radial nerve was severely injured so he was left with “radial nerve palsy”, meaning that the muscles that the nerve supplied no longer worked well. He was unable to move his fingers and wrist in extension and had numbness and burning pain in the back of the hand. The surgeon offered no physical therapy and informed him that it was unlikely that he would return to playing golf, one of his life long passions. This is because nerves heal very slowly and typically can take 1-2 years to return minimal function back to muscles.

We sent him for nerve conduction tests (NCS/EMG), prescribed specific nerve medication to help with his pain, hand therapy and bracing to prevent wrist contracture (when the joint becomes stuck in a nonfunctional position).  These are all the things his surgeon could have offered immediately, but didn’t. Regrettably, the nerve conduction studies showed a damaged radial nerve. At 6 weeks out from his injury we treated him with the new Regenexx procedure for nerve regeneration (hydrodissection of the radial nerve with our fourth generation  PL). Within 2 weeks of the first procedure he began noticing an increase in finger movement. He ultimately received 4 treatments over 6 months and below is his update at 9 months after his initial injury:

“I do not believe my recovery is a miracle!  I am convinced it is the result of sound medical science and skilled treatment.  My orthopedic surgeon and neurologist gave me little chance of resuming playing golf, due to my radial nerve palsy, emanating from a fractured left humerus.  The surgery to repair this injury required 9 screws and a plate.  My drooping left wrist and lack of any sort of fine motor skills with my hand were evidence of that.  Now, nine plus months after injury and seven plus months after beginning treatment, I now have 95% use of my wrist and 85%+ use of my hand.  My key indicator with regard to re-establishing my coordination is my golf handicap.  My handicap has grown from 3.8 to 4.9 and my low score post injury is 75 (twice), 3 over par.  My best the previous year was even par 72 (twice).  Golf is an extreme hand-eye coordination sport and I believe a good indicator of the level of recovery for my dexterity, strength and fine motor skills…I believe the nerve hydrodissection in four treatments has produced remarkable results.  Progress has now slowed, but is still proceeding.”

Coincidentally, this week we received another update from the patient, who is now 12 months post injury:

“Other than mild stiffness, my hand is about 90-95% of pre-accident condition.  Fabulous!”

We also repeated the nerve studies (NCS/EMG) and these showed objective and marked improvement of the nerve’s function.

The upshot? Nerve regeneration through precise guidance is revolutionary. We’ve seen enough great results with this procedure and we feel comfortable letting more patients know it’s available. There’s nothing quite as satisfying as seeing a patient who can’t move muscles because of a nerve injury, regain those capabilities as a result of what you were able to do as a physician. This is doubly so when they told you in medical school that things like this were impossible! At least my medical school dean was smart enough to also tell us, “about half of what we’re teaching you will be declared to be wrong at some point in your career”.

NOTE: Our clinical focus is on helping nerves that have been injured or become entrapped. Nerves that are cut in half with large gaps are likely too severe for this procedure.

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92 thoughts on “Nerve Regeneration – The Future Doesn’t Involve Surgery

  1. Mary King

    Can nerves that were damaged due to radiation?

    1. Regenexx Team

      Mary,
      Can you tell us more about the type of nerve damage from radiation?

  2. Mary King

    Be helped with this procedure?

  3. Donna Soldner

    Are pinched nerves the same as entrapped nerves and can this treatment help?

    1. Regenexx Team

      Donna,
      They are both compression nerve issues and sometimes the words are used interchangeably. Yes, this treatment can help.

  4. Barb

    Can this procedure help neuropathy of the feet.? I do not have diabetes.

    1. Regenexx Team

      Barb,
      Yes, it can.

  5. Anthony Valadez

    Has this been tested on multiple sclerosis patients? If so, how have results been for them?

    1. Regenexx Team

      Anthony,
      No, it hasn’t. No, MS is a different type of nerve issue. This treatment is designed for nerve compression issues, meaning the nerve has been damaged due to the physical force of something.

  6. Florence

    Husband had knee surgery 7-22-15. Resulting nerve damage is very uncomfortable for him. Will this treatment help him? Is this procedure covered by Medicare?
    I need knee surgery (bone on bone- determined severe by Dr) I don’t want to have knee replacement . Am I a candidate ? Also have 5 ruptured disc and stenosis. I had back surgery and it left me worse than before surgery. Will thus procedure help this?

    1. Regenexx Team

      Florence,
      No stem cell procedures are covered by Medicare or Medical Insurance in the USA. In reference to the nerve damage resulting from your husband’s knee surgery, it depends on the type of nerve damage. We have been successful in treating compression nerve injury. If a nerve has been severed, this will not help. Bone on bone knee arthritis is something we treat daily. What type of back surgery did you have? Depending on what type of back surgery was done, Regenexx PL, which is a proprietary platelet procedure designed to treat Discs might be able to help. You can also private message us at https://www.facebook.com/Regenexx/ by clicking on the message button on the lower right of the scenic image.

  7. Mark

    What is the typical cost for PL injections in the lumbar spine for multiple levels?

    1. Regenexx Team

      Mark,
      Bilateral levels like L3-L4 and L4-L5 would be $849.00 + $400.00 =$1,249.00
      One level- L3-L4 or L4-L5 would be $599.00 + $200.00= $799.00

  8. Richard Kugel

    Have you ever treated someone who had POLIO as a child??

    1. Regenexx Team

      Richard,
      Yes. This polio patient with severe hip arthritis had about an 80% relief for two years with the cultured procedure: http://www.regenexx.com/blog/severe-hip-arthritis-treated-with-stem-cells-two-year-update/ I don’t think any other aspect of polio would respond well to stem cells.

  9. Frank

    How effective is the treatment for thoracic outlet syndrome and carpal tunnel?

    Frank

    1. Regenexx Team

      Frank,
      We treat Carpal Tunnel Syndrome and Thoracic Outlet Syndrome regularly. This link will take you to several blogs written on Carpal Tunnel Syndrome: http://www.regenexx.com/?s=carpal+tunnel+syndrome, and this how we treat it: http://www.regenexx.comhttps://regenexx.com/blog/conditions-treated/hand-and-wrist/. TOS: http://www.regenexx.com/hands-numb-while-sleeping/ and http://www.regenexx.com/the-regenexx-procedures/shoulder-surgery-alternative/

  10. Mark

    Left a comment earlier about cost of PL. Someone responded with billable to insurance if in network, just spoke with someone from your office and they told me that no regenerative procedures are covered under insurance.
    Confused?

    Thanks,
    Mark

  11. Ann Nebraski

    I was in an accident 2 1/2 years ago. I have a brachial plexis nerve injury. I had a nerve transfer in Nov. 2013. I gained use of my tricep and my wrist, but not my hand. I was told that the muscles had set up atrophy and the nerve did not regenerate in time. I then had a tendon transfer to my hand and fingers. I have very little finger extension and movement. Can stem cell therapy help regenerate the nerves and revive the muscles?

    1. Regenexx Team

      Ann,

      I think it’s really important to discern what is and isn’t possible so that we inform your search forward, rather than giving false hope. I did inquire of Dr. Centeno. His reply:

      “I think it’s unlikely that given your extensive history that we would see return of muscle function in the hand using our procedure to help the nerves. I also think it’s unlikely that stem cells would help.” ~ Dr. Centeno

  12. Ryan

    Barb, back on December 11, 2015, mentioned this could help with neuropath. How about more specifically familial peripheral neuropathy, and how can I found out more details?

    1. Regenexx Team

      Ryan,
      Unfortunately, there is nothing we can offer for Familial Peripheral Neuropathy.

  13. jo

    Hi,
    Does this treatment help with pudendal nerves or obturator nerves ?

    Thanks

    Jo

    1. Regenexx Team

      Jo,

      Yes, generally speaking we can treat the Pudendal nerve at Regenexx Headquarters in Broomfield Colorado. If you’d like to see if your particular situation would be a Candidate for a procedure, please submit the Candidate form so we can discuss. http://www.regenexx.com

  14. Urvish Patel

    Any test cases with the damaged/pale optic nerve caused by optic nerve stroke(ischemic optic neuropathy)

    1. Regenexx Team

      Urvish,
      Our practice and research is exclusively in using stem cells in Interventional Orthopedic application. There is some research going on re ischemic optic nerve treatment. This search term, “ischemic optic nerve stem cell treatment pubmed”, will bring you a series of published papers on the topic.

  15. Freida Odum

    I have sural nerve damage in fact I have had surgery and it is worse.
    Can you help me.

    1. Regenexx Team

      Feida,
      We’d need to kow more about what is going on. Please submit the Candidate form here: http://www.regenexx.com/nerve-regeneration/

  16. Matt Wesley

    I have had 4 back surgeries am fused at l4-5 I have fusion at c5-6-7 I have good emgs but I still get pain in rt leg and lft arm with occasional numbness in both would your treatment help I’m years out on both neck and back surgeries . I’m 52 yr old male thanx

    1. Regenexx Team

      Matt,

      We treat post fusion patients regularly as Adjacent Segment Disease is generally the long term result of Fusion. Please see: http://www.regenexx.com/blog/neck-epidural-failed/ and http://www.regenexx.com/blog/types-of-back-fusions/ If you’d like us to weigh in on your case, please submit the Candidate form.

  17. Robert Gatlin

    I had the parotid salivary gland removed due to cancer. The right side of my face droops badly. It has been one year and no improvement. The surgeon is sure that he did not cut or damage the nerve. I believe he may of had to move it as the tumor was under the nerve. He says he traced the nerve both ways and could see no problems. He says that he has never seen a case that did not recover within less than one year. Is it possible that your treatment could help this?

    1. Regenexx Team

      Robert,
      The expert in this area is Dr. Victor Ibrahim: http://pmrcenter.org/victor-ibrahim-m-d/ He has presented at the Interventional Orthopedics Foundation Conference on his ground breaking regenerative work on Facial Palsy.

  18. Larry

    At 86 years old, am I a good candidate for any stem cell treatments? My feet feel like I’m walking on water most of the time and my balance is terrible. I’ve had double-knee replacement surgery (2002) and a laminectomy/fusion back surgery (2012). My foot flopping started after my knee replacements. I also have restless leg syndrome. I’m currently undergoing testing for possible bone cancer (PET Scan showed spots at hip and at L9 in the spine). Should I be looking at doing any stem cell treatment at all while I’m still being tested for cancer? My daughter is very skeptical and both my Primary and Orthopedic physicians do not think that I am a good candidate at this time. Do you have a specialist that handles my particular situation that you can recommend?

    1. Regenexx Team

      Larry,
      We wouldn’t consider stem cell therapy in a patient actively undergoing a cancer workup. However, if your foot weakness started after the knee replacements, it’s possible there may be a surgical injury to the nerves that supply those muscles and that this may respond to platelet lysate hydrodisection.

      1. Larry

        So, are you saying that I could still possibly do the platelet lysate hydrodisection whilst undergoing a cancer workup? Is there a specialist that you can recommend?

        1. Regenexx Team

          Larry,
          Yes. The only Dr’s qualified to do a procedure like this would be those in our Network. Please see: https://regenexx.com/find-a-physician/

  19. Larry

    In your answer to me (above) you say that “platelet lysate hydrodisection” may help me if I have surgical injury to the nerves; however, in another answer on this forum you told someone “if a nerve has been severed, this will not help”. I’m confused….can you please clarify? Thank you, Larry.

    1. Regenexx Team

      Larry,
      Sure, there is a difference between a severed nerve, meaning cut, and a nerve that was injured in surgery. This explains in more detail: https://regenexx.com/blog/nerve-regeneration/

  20. Benjie

    Hi,
    Are you able to treat spinal compression? I got fused from T10 to T12. The compression was due to over weight and bone spurs pressing on my spine. After my surgery, i can’t fully feel my lower part of my body, from waist down. I can control my bowel movements. Right now am doing physio therapy. I can walk but too slow and not really stable, i walk with my crutches or quad cane. I sonetimes use my wheelchair. i can’t feel them. I have trouble bending my right leg and foot. Any way would this treatmemt work for me?

    1. Regenexx Team

      Benjie,
      When was your Fusion?

  21. David Lott

    Cervical fusion at c4-c5, c5-c6, c6-c7
    still having neck pain only at 2 years post op, no pain in arms or hands. My pain Dr wants to try PRP in the epidural spaces at the fused levels with the hope of healing any nerve damage/pain . Obviously there is no discs there anymore to try and heal, so it would really be just trying to heal the nerves etc.. in the epidural space. Is this something ya’ll have done in the past and had success with ?

    1. Regenexx Team

      David,
      In adjacent segment disease, meaning the overload of forces affecting the vertebrae above and below the fusion which is inevitable, we use specialized platelet procedures, and in some cases stem cells. Please see: https://regenexx.com/blog/pain-after-back-fusion-adjacent-segment-disease/ and https://regenexx.com/blog/neck-epidural-failed/ and https://regenexx.com/the-regenexx-procedures/back-surgery-alternative/ Ordinary PRP (the type made by machine) tends to be quite inflammatory, and these types of spinal procedures require Fluoroscopy guidance, and a great deal of experience.

  22. Marcus

    Very interesting read. I have been diagnosed with scalp dysesthesia with potential nerve damage. Could this procedure benefit me?

    1. Regenexx Team

      Marcus,
      I have inquired…

  23. David Lott

    Do ya’ll do cervical PRP injections at your own facility so as where the patient doesn’t have to pay a non insurance covered fee for the use of a separate hospital facility ? If so what are the cost for for the injections themselves , and is that the only fee required ?

    1. Regenexx Team

      David,
      Yes, we do cervical injections with Platelet procedures in the Procedure suites of the Clinics themselves with Fluoroscopy guidance. The exam is covered if your insurance is in network, but for more detail about what else might be covered and price you’d need to call 888 525 3005, 8-5 MST.

  24. Cathy Cinciatta

    Hello,
    I have had foot-drop for many years (over 20), that occurred after ankle reconstruction surgery. In all of these years, I have not been able to find any medical professional that gives me any hope that anything can be done (except AFO).
    I have also not been able to get a proper diagnosis on what exactly is wrong anatomically. I have had EMGs done, but… they all just indicated that there was ‘damage’. That was not very useful. I have been left to guess that something associated with that surgery induced peroneal nerve damage (after doing my own research, finding out that the peroneal nerve is what is behind the dorsiflexion that I can no longer do). I was wondering if any of your therapies can regenerate a damaged peroneal nerve that is an old ‘injury’, such as the one I described. Thank you !

    1. Regenexx Team

      Cathy,
      Did the EMGs indicate the peroneal nerve specifically?

      1. Cathy Cinciatta

        Hello,
        Unfortunately, I do not know. I think the information that was give was very vague, and did not include what exactly was damaged. I believe the terminology that was used was ‘There is significant nerve damage’. At this late point, is this something that I need to do again (hopefully a practitioner that is more suited to my situation than I have had in the past)…. and get the answer to that question ? The EMGs that were done were at different points… all years ago. While I am on the subject… are there tests (be it EMG, or perhaps another more exacting test that is newer??) that can determine the actual location within the peroneal nerve that is damaged, and the length of the damage ? Thank you very much for your prompt reply to my comment. Cathy

        1. Regenexx Team

          Cathy,
          This was a similar case: https://regenexx.com/blog/regenerating-radial-nerve-injury-injections/ however it was a relatively recent injury. Unfortunately, 20 years is likely too long ago to make a difference.

  25. Amy Crawford

    Hi there, at the end of 2016 I had surgery for my compartmental syndrome in my lower right leg. Because of the surgery I have significant nerve damage, and I developed foot drop, and I rely upon an AFO for support in my daily activities. I’m wondering if I might be a good candidate for your nerve regeneration procedure???

    1. Regenexx Team

      Amy,
      It would depend on the type of nerve damage. When nerves are inured, entrapped or scarred due to surgery they can become compressed which doesn’t allow the signal to get through, and we can often help with that. Have you had NCS/EMG testing done?

  26. diane

    Hi.
    Can this treatment help with ulnar nerve palsy ? My partner got an accidental cut on his elbow and as luck wouls have it, he sustained a nerve cut.. he has had emergency surgery and hand therapies but seems that his hand is now clawing. His hand often goes numb and painful
    Will this procedure help restore his nerves ?

    1. Regenexx Team

      Diane,
      This procedure works well on compressed or injured nerves, but not nerves which have been severed. Has he had any nerve testing done?

  27. Rip

    According to a neurologist, a neuro surgeon and others who present themselves as neuropathy experts, I have idiopathic peripheral neuropathy. I do not have diabetes, no cancer drugs and no damage due to trauma . Both feet feel numb all the time and the sense of numbness changes throughout the day relative to what I may be doing. It is better or less noticeable when I am walking. There are also varying degrees of burning, stinging, tightness and some of these symptoms are ameliorated by leg and back stretches temporarily. The numbness increases by a factor of roughly five at the moment I get horizontal for sleep. I have tried near infrared therapy, nutritional supplements, chiropractic adjustments and I am currently receiving PRP injections that do not seem to have helped. I have had injections to my feet and along the outside of my legs every other week for the past six weeks. Has your group successfully used PRP or your PL treatment with the neuropathy I describe?
    I am a 70 year old male and I have tolerated the neuropathy for well over 10 years but over the past year the other symptoms I mentioned have occurred .

    1. Chris Centeno Post author

      Yes we have, but I would have to know more. Where are they injecting the PRP? Are they using ultrasound guidance or performing these procedures blind?

  28. Syed

    Does drug induced peripheral neuropathy treated age 30 yrs no diabetes

    1. Regenexx Team

      Syed,
      Peripheral neuropathy can be caused by different things. Drug induced peripheral neuropathy often takes time to resolve after the offending medication has been stopped, though some cases don’t resolve. Are you still taking the medication? What type of medication is thought to have caused this issue?

  29. Darren

    I have had 3 surgeries on my L5-S1 to relieve sciatica. I was fine after the 2nd one until the bone grew over the sciatic nerve. I had the 3rd surgery to release the nerve and replace hardware. It was quite traumatic. Now I have a damaged sciatic nerve. Could this treatment help?

    1. Regenexx Team

      Darren,

      We have seen some evidence that the growth factors in platelet lysate may be able to help damaged nerves, so our usual treatment for this type of problem is a platelet lysate epidural.

  30. Nancy Gardiner

    Can this help with severe peripheral nerve damage caused by axonal Guillain-Barre syndrome?

    1. Chris Centeno Post author

      Unknown

  31. Jennifer Santander

    I haven’t been diagnosed yet, but I think I might have nerve entrapment or some nerve damage from cutting my abdominal muscles when I had my gallbladder removed. Can you treat that?

    1. Regenexx Team

      Jennifer,
      Where is the nerve in question?

  32. Marina

    Would this help with a spinal cord injury? L1 incomplete as a result of a fall, July 2015. Emergency decompression surgery with metalwork.

    1. Regenexx Team

      Marina,
      Not this procedure. But there is a lot of research and hope for the future.

  33. Brent

    I have a foot drop due to L5 – SI pinched nerve. Can this procedure help me?

    1. Chris Centeno Post author

      Unknown in your specific case, but I have treated patients with foot drop who have recovered some function.

      1. Brent

        Can the pinching of the nerve and back pain be treated by Stem cell therapy?

        1. Regenexx Team

          Brent,

          Depending on the issue either platelet procedures or stem cell procedures.

  34. Myra Fletcher

    can this help with west nile victims wirh poliomyelitis below right knee only

    1. Regenexx Team

      Myra,

      Unfortunately, not at this point.

  35. Karin Lucey

    Is this treatment helpful in treating facial nerve injury post-op jaw replacement surgery in
    5–1–2012?

    1. Regenexx Team

      Karin,
      We’d recommend this provider in the DC metro area as he is a specialist in trigeminal neuralgia: http://pmrcenter.org/victor-ibrahim-m-d/

  36. Bob Weyland

    I have foot drop due to a bulged L4 L5 disc about 15 months ago. I had a discecotomy that the surgeon deemed successful within 2 weeks but only regained 50% recovery. Could your treatment help?

    1. Chris Centeno Post author

      It’s possible. I have helped other similar patients. We usually start with a platelet growth factor epidural and hydrodissection of the nerve using precise ultrasound guidance.

  37. Michael Cavalieri

    I was hoping to try PL around my entrapped illioinguinal and illiohypogastric nerves. I’ve lost most feeling innervated by them. Would giving ultrasound guided PL be an option for me?

    1. Chris Centeno Post author

      Yes, this may help.

  38. Alexander Ferguson

    I had spinal decompression surgery on July 25 on L2,3 L3,4 AND L4,5. Prior to my recent surgery I had spinal decompression surgery 4 years prior on one of the previous but not sure which one but it left my little toe on my right foot numb. I was told it would probably recover and feeling would be restored but it never did. Now after this surgery my whole right foot is numb. My surgeon this time also said it would probably recover but I’m a little pessimistic about it. If after a few month or a year the numbness does not go away would this treatment be something that would help?
    Thank you.

    1. Chris Centeno Post author

      This type of procedure may help, but I would need an MRI and exam to know more and provide a better sense of candidacy.

  39. Barb

    I have secondary radial nerve entrapped in scar tissue lateral to screw fixation. It’s been 13 months and I have improved but was told without surgery I will never fully recover.

    1. Regenexx Team

      Hi Barb,
      I think you’ll find this Blog about a very similar case interesting: https://regenexx.com/blog/radial-nerve-treatment/ and https://regenexx.com/conditions-treated/hand-and-wrist/ To see if your particular case would be a Candidate, please submit the Candidate form here: http://www.regenexx.com and please notify us here when you’ve done that.

  40. Chase Cato

    I suffered a spinal accessory nerve injury from a bite the the neck September 20 2018 so it has been about 5 months since the injury occurred. I’ve had 2 EMGs done with the first showing no conduction of the nerve and the second EMG which was done about 3 months post injury showing conduction was back with a reasonable good prognosis but I want to do everything I can to ensure that I get the best outcome I can. The doctor said it was a axonitmesis crush type injury of the spinal accessory nerve. I still have lateral winging if my scapula due to the fact that my trapezius muscle isn’t firing the way that it should. I hope that something like this can help my nerve regenerate and Reinnervate my trapezius muscle back to nearly 100%. Would this procedure help or has too much time elapsed since the time of injury?

    1. Regenexx Team

      Hi Chase,
      It’s likely we can help, but would need to take a closer look at the results of all of the tests you’ve had done. Please submit the Candidate form here: http://www.regenexx.com

  41. Barb

    I have radial nerve entrapped in scar tissue after CRIF with a screw causing radial nerve entrappment. Dr. wants to operate to release the radial nerve but I asked about Regenerx injections and he made a nasty comment on my office visit notes about stem cell injection. Could you please let me know? I don’t want more surgery with a chance of bad outcome

    1. Regenexx Team

      Hi Barb,
      Based on the types of things being marketed as stem cell therapy, that’s understandable. Please see: https://regenexx.com/blog/radial-nerve-treatment/ We’d need more information to see if your particular case would be a candidate. Please submit the Candidate form here: http://www.regenexx.com

  42. Hemalatha

    I am a 69 yrs old woman from India. Suffered central retinal artery occlusion with cilioretinal retinal artery sparing last year in March. Do you have any stem cell treatment to treat this condition. Will be very grateful for any help and advice you can offer me. My optic nerve is damaged. I can mail my medical records if required.

    1. Regenexx Team

      Hi Hemalatha,
      Sorry we can’t help, as our research and treatment is in the area of regenerative Interventional Orthopedics, exclusively. Good places to keep advised of advances in different medical fields is PubMed, as it contains the peer reviewed published research. It’s also an area to be very careful in. Please see: https://regenexx.com/blog/ftc-nails-magic-amniotic-cure-all-stem-cell-clinic-the-beginning-of-the-end-for-amniotic-and-cord-vendors/

  43. bruce mcfadden

    I had footdrop and severe sciatica. L4-5 microdiscectomy relieved the pain in 2012 but moderate-severe polyneuropathy was diagnosed in 2015 and imbalance and footdrop persisted. Intravenous & ankle stem cell therapy (sct) in 2018 relieved foot, ankle and hand discomfort and helped joint mobility as did Eligen B12. However I still have serious imbalance and footdrop which have elevated my fall rate. I am open to more sct. What would you recommend?

    1. Regenexx Team

      Hi Bruce,
      We’d need more information through a Candidacy review to advise. Please submit the candidate form here: http://www.regenexx.com or give us a call at 855 622 7838 and we can assist.

  44. Shabnam

    My dad has been suffering from a severe case of foot drop for many years and now causing him to have extreme swelling of the foot and pain and naturally losing his balance and multiple falls. Does this procedure considers to be possible for such cases?

    1. Regenexx Team

      Hi Shabnam,
      Has the cause of the foot drop been diagnosed?

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
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Regenerative procedures are commonly used to treat musculoskelatal trauma, overuse injuries, and degenerative issues, including failed surgeries.
Select Your Problem Area
Shoulder

Shoulder

Many Shoulder and Rotator Cuff injuries are good candidates for regenerative treatments. Before considering shoulder arthroscopy or shoulder replacement, consider an evaluation of your condition with a regenerative treatment specialist.

  • Rotator Cuff Tears and Tendinitis
  • Shoulder Instability
  • SLAP Tear / Labral Tears
  • Shoulder Arthritis
  • Other Degenerative Conditions & Overuse Injuries
Learn More
Cervical Spine

Spine

Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Knee

Knees

Knees are the target of many common sports injuries. Sadly, they are also the target of a number of surgeries that research has frequently shown to be ineffective or minimally effective. Knee arthritis can also be a common cause for aging athletes to abandon the sports and activities they love. Regenerative procedures can be used to treat a wide range of knee injuries and conditions. They can even be used to reduce pain and delay knee replacement for more severe arthritis.

  • Knee Meniscus Tears
  • Knee ACL Tears
  • Knee Instability
  • Knee Osteoarthritis
  • Other Knee Ligaments / Tendons & Overuse Injuries
  • And more
Learn More
Lower Spine

Spine

Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Hand & Wrist

Hand & Wrist

Hand and wrist injuries and arthritis, carpal tunnel syndrome, and conditions relating to overuse of the thumb, are good candidates for regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Hand and Wrist Arthritis
  • Carpal Tunnel Syndrome
  • Trigger Finger
  • Thumb Arthritis (Basal Joint, CMC, Gamer’s Thumb, Texting Thumb)
  • Other conditions that cause pain
Learn More
Elbow

Elbow

Most injuries of the elbow’s tendons and ligaments, as well as arthritis, can be treated non-surgically with regenerative procedures.

  • Golfer’s elbow & Tennis elbow
  • Arthritis
  • Ulnar collateral ligament wear (common in baseball pitchers)
  • And more
Learn More
Hip

Hip

Hip injuries and degenerative conditions become more common with age. Do to the nature of the joint, it’s not quite as easy to injure as a knee, but it can take a beating and pain often develops over time. Whether a hip condition is acute or degenerative, regenerative procedures can help reduce pain and may help heal injured tissue, without the complications of invasive surgical hip procedures.

  • Labral Tear
  • Hip Arthritis
  • Hip Bursitis
  • Hip Sprain, Tendonitis or Inflammation
  • Hip Instability
Learn More
Foot & Ankle

Foot & Ankle

Foot and ankle injuries are common in athletes. These injuries can often benefit from non-surgical regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Ankle Arthritis
  • Plantar fasciitis
  • Ligament sprains or tears
  • Other conditions that cause pain
Learn More

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*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.