The Top 3 Causes for Butt Pain

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The idiom “pain in the butt” is a common one, typically used when someone or something is particularly annoying; however, butt pain is very real, and when it happens to you, it’s not only annoying but can also be severely painful and disabling.

There are three common causes we frequently see in the clinic in a patient that presents with butt pain. Let’s explore these causes and how to treat them.

1. Butt Pain Caused by Hamstrings Tendinopathy

The hamstrings are a group of muscles that live in the back of the thigh and stretch from the back of the knee to the butt. The hamstrings attach at the butt in the bone you sit on, called the ischial tuberosity.  Hamstrings tendinopathy occurs when the tendon that connects the muscle to the bone becomes degenerated with wear and tear or traumatized.

How to treat hamstrings tendinopathy: If it doesn’t get better with physical therapy (PT) or with time, a precise ultrasound-guided injection of high-dose platelet rich plasma (PRP) will usually take care of the problem.

How not to treat hamstrings tendinopathy: It’s important to avoid steroid shots in the tendons as these will degenerate the tissue and deplete stem cells. Surgery is usually overkill and not recommended for the hamstrings due to its side effects and recovery time. The caveat may be when there is a large tear in the hamstrings, and it’s pulled apart like a rubber band.

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2. Butt Pain Caused by SI Joint Syndrome

Sacroiliac (SI) joint syndrome occurs in the lower back, between the back of the hip and the tailbone. The pain from this problem is located at the dimples of Venus (indicated with a red spot on an image in the brief video above). The pain can also radiate into the meat of the butt as well as other areas like the groin or side of the hip. The SI joint can be injured in trauma or childbirth, and it can also refer pain into the groin area.

How to treat SI joint syndrome: If it doesn’t get better with PT or chiropractic care, a precise image-guided injection of high-dose platelet rich plasma (HD-PRP) or high-dose stem cells (HD-BMC) into the joint and surrounding ligaments should do the trick. Prolotherapy also works well.

How not to treat SI joint syndrome: Avoid steroid shots for SI joint syndrome as these can injure ligament and cartilage cells as well as impact bone density, particularly in older women. Surgery to fuse the SI joint is also ill advised as, for starters, rendering the SI joint immovable overloads the lumbar spine and the hip joint and eliminates the SI joint’s shock absorbing function.

3. Butt Pain Caused by a Pinched Nerve in the Low Back

A pinched nerve in the low back may cause pain or numbness down the leg, but it also can cause butt pain without any numbness down the leg. This happens because irritated nerves in the back cause the butt muscles to misfire, leading to tendinopathy or butt pain. A pinched nerve can occur, for example, when there is a problem with a spinal disc (the cushion between the bones of the spine), such as a bulging or herniated disc, or when there is arthritis in the spine joints. In these cases, the foramen, the tunnel the nerves travel through, can narrow (foraminal stenosis), causing pinched nerves.

How to treat a pinched nerve in the low back: If PT fails, a precise X-ray–guided injection of platelet growth factors around the irritated nerves usually helps. This is different than PRP, see the video here for more information. One of my favorite success stories involves a fellow physician who had suffered from severe butt pain after a fall and was walking with a cane. His butt pain was due to a pinched nerve, and following treatment, he was able to lose the cane.

How not to treat a pinched nerve in the low back: Steroid shots, for the same reasons discussed in the other two diagnoses above, and surgery to treat pinched nerves really should be avoided.

Piriformis syndrome, while a rare condition, is also worth mentioning. This occurs when the piriformis muscle compresses the sciatic nerve, causing butt pain and usually numbness down the leg. The piriformis muscle sits at the geographic center of each side of the butt and stretches east to west. The reason why I don’t include Piriformis syndrome as a primary diagnosis is that it’s usually caused by either SI joint syndrome or pinched or irritated low-back nerves that supply the muscle.

The upshot? Butt pain can be caused by a number of issues, including hamstrings tendinopathy, SI joint syndrome, a pinched nerve, and even piriformis syndrome. However, with effective nonsurgical options available in regenerative medicine today, you don’t have to live with an annoying pain in the butt!

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This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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12 thoughts on “The Top 3 Causes for Butt Pain

  1. Jan Tucci

    I have been advised to have a spinal injection….epidural steroid ….
    I understand it to be placed at L3, L4 &L5. Would love to hear from someone who has experienced this

    1. Regenexx Team Post author

      Eidural Steroid injections can give short term pain relief. The problem is they make the situation worse in the long run as they breakdown cartilage, kill the local stem cells and can damage tendons. Please see: and

  2. Tommy

    This is how the back doctor makes is money, one shot at a time and since Medicare will pay for them they go on and on. Not only are they only temporary relief, they can lead to serious complications. Educate yourself about PRP and Stem Cells from an ortho who has experience with these procedures. There is an abundant material on line to use as an introduction.

    1. Regenexx Team Post author


      Been trying to get the memo out for many years! Was shocked to hear a 4th year Med student applying to Residency programs listing steroid injections as the “best practice” treatment for joint issues, just this week…

  3. Beth

    Have you had success in regenerating torn sacroiliac ligaments or the tendons in that area? If so, can ultrasound be used for guidance?

    How about for injections into the SI joint. Can ultrasound be used or must fluoroscopic be used?

    1. Regenexx Team Post author

      We treat these issues regularly. Ultrasound is better for looking at the ligaments and fluoroscopy is better for making sure that the injection goes inside the joint. So it’s one of those situations where to do the best work you need both.

  4. Tara

    How could I find out which cause I have? Would an MRI give me the answer? I have pain in the middle of my butt and also a sharp pain in my hamstring area. At times the pain is worse in the hamstring area. This is also the second time this has happened to me. The first time I went through ART (Active Release Technique) and PT and it solved the issue. Since this is the second time, I am curious if it is the Piriformis syndrome or something different.
    Thank you!

    1. Regenexx Team Post author

      MRI is a tool, but diagnosis requires a thorough exam, and Orthopedics gets into trouble when treatment decisions are made based on the bright shiny object on an MRI. Dr. Bashir in North Miami (Aventura) can do that type of exam, and advise. He can be reached at 305 760 4642 . Here’s his website:

      1. Tara

        Thank you very much! I live in Tampa, is there a doctor closer to than Miami?

        1. Regenexx Team Post author



          Tampa/Sarasota. Please see:

  5. George Williams

    Can a pet scan identify the cause of butt pain? Willing to pay anyone who can finally help me get rid of this persistent annoying pain

    1. Regenexx Team

      Hi George,
      It depends on the type of butt pain. A PET scan is useful in identifying cancer, heart issues and brain issues. Several different types of cancers and issues which could cause certain types of pain in that general area could show up. As it covers in the Blog, the top 3 causes of butt pain are musculo-skeletal or spinal issues, which would need an MRI and an extensive exam to diagnose.

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