My New Annual All Stem Cell Type Orthopedic Infographic

by Chris Centeno, MD /

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As I promised yesterday, for the first year ever, I have updated my orthopedic stem-cell-research infographic to include other stem cell sources outside of bone marrow. It’s exciting to finally have enough data on fat to believe that it will be a factor in what’s best for orthopedic patients.

My Issues with Fat

The biggest long-term problem I have had with the use of fat stem cells to treat orthopedic conditions has been the lack of data. The animal data wasn’t all that convincing, and little human data existed. In 2015 and 2016 that began to change as I noted several papers being published. Hence, it was time to declare that fat stem cells may have a place alongside bone marrow in orthopedic care.

What’s New in Orthopedic Fat-Stem-Cell Research?

Most of the published fat-stem-cell studies are on knee arthritis with some publishing on the ankle. More importantly, almost all high-quality studies are out of Korea. So just as the U.S. has lost the orthopedic bone-marrow-stem-cell lead to Spain, in fat stem cells, it’s losing to the Koreans. How is it possible that we as a country have funded 100X or more basic-science stem cell research than the Koreans and that they are trouncing us in clinical studies? Their version of the FDA has allowed fat stromal vascular fraction (SVF or a same-day fat-stem-cell procedure), whereas ours has considered it a drug. While this hasn’t stopped many clinics from floating the regulatory risk, it’s clear that separating stem cells from fat is illegal in the U.S.

How Does the Fat-Stem-Cell Research Stack Up Against Bone Marrow?


The graphs to the left show that bone marrow research in orthopedics still dominates the landscape. This is based both on a comparison of the number of papers as well as the number of patient results reported. It should also be noted that the largest stem cell paper on fat used outcome measures that were mostly determined by the providers and not the patients. It should also be pointed out that this is the only paper that used a US legal fat graft alongside the US illegal SVF. That study found no difference in outcome between SVF and a fat graft.

How Do You Use This Document?

First, click on the image above to see a live PDF. Second, each circle, square, and triangle above are a link to the study listed. The circles are bone marrow studies, the squares are fat based, and the triangle represents birth tissues (in this case cord-blood stem cells). Inside those shapes, you’ll find the author’s name, body-area focus of the study, the number of treated patients, and then the type of cells used. Please notify me if I’ve missed any studies because all of this is based on multiple PubMed searches. Also, if you catch a bad link, please drop me a line as well. The e-mail address that goes to my desk is [email protected]

The upshot? Fat fans, welcome to the stem cell research world! Many people thought I was anti-fat, yet for me it’s all about the research. So as the new studies rolled in, it’s clearly time to move from an annual bone-marrow-stem-cell-research infographic to an all-cell-type orthopedic-stem-cell-research infographic!

Adipose Grafts

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4 thoughts on “My New Annual All Stem Cell Type Orthopedic Infographic

  1. Anne In San Antonio

    I have had 2 SVF treatments on my arthritic ankle one in April 2015 and one in April 2016. and my results have been very good. Peak relief at 6 months with a slight increase in pain by year one. But with each treatment my eventual result is better than at the start of each increment. Now I am seeing Dr. Markle and he will be treating the ankle next w BMA. After my knee heals enough. I say it is all good. I am surprised that the tummy fat process is illegal as that fact was not presented to me here in Texas. The PRP alone was not enough. The doctor told me my results were remarkable. I am simply thankful.

    1. Regenexx Team Post author

      Anne in San Antonio,
      As are we! Hopefully, Dr. Markle’s Regenexx treatment will complete the set…

  2. paul anteau

    What does the research say about amniotic stem cells used for hip therapy?

    How do the results using amniotic stem cells compare to the results when hip stem cells are used for hip therapy?

    1. Regenexx Team Post author

      Paul,
      We’ve not found any peer reviewed published research on that subject. However, our own lab research looking for live, viable stem cells in any Amniotic cell product we’ve tested, has shown no live viable stem cells. In practice, if the practioner used the correct type of imaging guidance, one would expect similar results to very much less expensive generic PRP.

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
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