Ask Dr. C-Episode 11-Can PRP Reduce Arthritis Progression?

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can prp slow the progression of arthritis

I still have a few more great questions to answer, but this one stood out. Can PRP or stem cells slow the progression of arthritis? Let’s dig in.

Can PRP and/or stem cells prevent further cartilage loss as opposed to regrowing cartilage?

I love this question because the holy grail of osteoarthritis treatment has long been to find a drug that can reduce the slow and steady decline of a knee or other joint once arthritis sets in.  Meaning, once you begin to get just a little arthritis, it’s almost a certainty that this will progress year over year to get a bit worse with time. Eventually, the joint slides down that slippery slope enough so that it’s bone on bone. This process happens more quickly in certain joints like the hip and can be slower in joints like the knee. Hence, if there was some drug or orthobiologic you could inject into, let’s say the knee, that would slow or stop this inevitable progression, that would be a game-changer in arthritis care. So is PRP or Bone Marrow Concentrate that game-changer?

I performed a brief literature review this morning of mostly newer studies and here’s what I found. First, realize that this wasn’t meant as an exhaustive review. However, some trends do emerge.

PRP was able to protect rabbit joints from arthritis by reducing the inflammation in the tissues and loss of cartilage matrix (1). In a rat study, PRP was able to avoid cartilage cells from going into apoptosis (preprogrammed cell death) which protected the cartilage from breaking down (2). In comparing PRP alone and Bone Marrow Concentrate (BMC or a same-day stem cell procedure), the BMC showed better cartilage protection than PRP which did better than saline (3).

In a clinical study with MRI tracking over time, despite having knee arthritis, 73% of patients who got PRP didn’t have a progression of their knee arthritis at one year (4). This study didn’t have a control group. In another study with controls, PRP reduced cartilage loss and swelling in the joint tissues (synovitis) at 8 months after injection (5). However, in another study out of Sapin, while PRP beat hyaluronic acid and NSAID drugs for pain and function, there was no difference in arthritis progression between the PRP and HA groups (6). However, it’s important to note that HA in and of itself could have a cartilage protection effect.

So, looking at this data, IMHO it’s more likely than not that PRP does protect most knee joints with arthritis from progressing and losing cartilage. That conclusion could change or be strengthened as more data is published.

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What Do I Do For Me?

As an expert in this area, I’ve been seeing this handwriting on the wall for years. Hence, I have my colleagues inject my knees with our high-dose PRP at least once a year. Sometimes that’s because they ache a bit in certain circumstances. Sometimes it’s because I’m getting other things injected and want to top them up from a regeneration standpoint. However, for me, the data is strong enough that this strategy makes sense to me. In fact, it makes so much sense to me that several years ago, I wrote a whole book on the topic:

This is a quick read, but I’d encourage you to dig into it.

The upshot? IMHO, PRP should be used as a way to reduce the progression of knee arthritis. That’s how I use the stuff personally and the published research to date is supporting that idea!


(1) Xue Y, Su X, Jiang M, Yu Z, Yang H, Qin L, Giannoudis PV, Guo JJ. Pure platelet-rich plasma facilitates the repair of damaged cartilage and synovium in a rabbit hemorrhagic arthritis knee model. Arthritis Res Ther. 2020 Apr 5;22(1):68. doi: 10.1186/s13075-020-02155-6. PMID: 32248827; PMCID: PMC7133006.

(2) Asjid R, Faisal T, Qamar K, Khan SA, Khalil A, Zia MS. Platelet-rich Plasma-induced Inhibition of Chondrocyte Apoptosis Directly Affects Cartilage Thickness in Osteoarthritis. Cureus. 2019 Nov 1;11(11):e6050. doi: 10.7759/cureus.6050. PMID: 31827985; PMCID: PMC6890159.

(3) Wang Z, Zhai C, Fei H, Hu J, Cui W, Wang Z, Li Z, Fan W. Intraarticular injection autologous platelet-rich plasma and bone marrow concentrate in a goat osteoarthritis model. J Orthop Res. 2018 Feb 21. doi: 10.1002/jor.23877. Epub ahead of print. PMID: 29464749.

(4) Halpern B, Chaudhury S, Rodeo SA, Hayter C, Bogner E, Potter HG, Nguyen J. Clinical and MRI outcomes after platelet-rich plasma treatment for knee osteoarthritis. Clin J Sport Med. 2013 May;23(3):238-9. doi: 10.1097/JSM.0b013e31827c3846. PMID: 23238250.

(5) Raeissadat SA, Ghorbani E, Sanei Taheri M, Soleimani R, Rayegani SM, Babaee M, Payami S. MRI Changes After Platelet Rich Plasma Injection in Knee Osteoarthritis (Randomized Clinical Trial). J Pain Res. 2020 Jan 10;13:65-73. doi: 10.2147/JPR.S204788. PMID: 32021396; PMCID: PMC6959502.

(6) Buendía-López D, Medina-Quirós M, Fernández-Villacañas Marín MÁ. Clinical and radiographic comparison of a single LP-PRP injection, a single hyaluronic acid injection and daily NSAID administration with a 52-week follow-up: a randomized controlled trial. J Orthop Traumatol. 2018 Aug 20;19(1):3. doi: 10.1186/s10195-018-0501-3. PMID: 30128934; PMCID: PMC6102156.

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10 thoughts on “Ask Dr. C-Episode 11-Can PRP Reduce Arthritis Progression?

  1. Dan

    I know its easier said than done but isn’t a correction of biomechanics the holy grail? Correct me if Im wrong but isn’t osteoarthritis a rxn in the body to physical stress? Wouldn’t removing the physical stress through correction of the patients biomechanics solve the issue? I think this is an over simplification but I think you get the idea.

    1. Chris Centeno, MD Post author

      That would be more my personal take, but if you talk to cartilage researchers, their version of the holy grail would be an injectable that slows the progression of the disease.

  2. Frank C Romeo

    Why not PRP and HA together or 6 weeks apart.

    1. Chris Centeno, MD Post author

      They can be used together, there is research on using them in tandem.

  3. Phyllis

    I had prp in L3, L4 ,and L5 to slow the arthritis . Can this be done safely in the neck too?

    1. Chris Centeno, MD Post author

      Yes, we treat neck issues all the time.

  4. Vicki

    I finally took the leap last January 23, 2020 & (supposedly) got 1ml of Whartons Jelly combined w/Exsomes (sp?) injected into both knees & left shoulder. NEVER experienced ANY relief. Had been contacting Vibrant Health in Scottsdale about it almost immediately. For $7,500 you’d expect “something.” I even met w/owner asking for a refund, which he declined. I want to finance company next. I’ve been going thru HELL since last January. When you soooo look forward to relief & have NONE-What is next?
    Vibrant PROMISED on their website & in person to use “guided imagery” and didn’t! Half of my left knee injections ran down my leg. What’d doc do? He wiped it off & finished what was left, on the other side of that knee! Both knees were Grade 4, with a Grade 2 shoulder. Had all MRIs w/me, didn’t utilize them.
    I NEVER filled out my own loan docs, nor did Vibrant EVER ASK what my annual income was. I’m getting stalled by finance company. I need to get the loan REVERSED & get it off my credit report. I don’t believe Vibrant gave me REAL injections. I believe the doc took my injections for himself. WHAT company doesn’t ask your annual income?
    I’ve been told I SHOULD’VE had my own stem cells pulled, spun & reinjected in one procedure/office visit by another company. I’m 69 years old & knees are shot because of 40 years in the gym! I will NEVER have knee replacements. They replaced right hip, screwed up & had to go thru revision 10 months later. All because of an arthritic right hip & a dim-witted doctor.
    I’ve started the Medicare approved amniotic fluid injections & am wondering IF those are even going to work. This business says “45” day intervals.
    Can you guys pleeeease help me, and/or give me advice on what to do next? I’m barely able to get around, & we own a 2 story home. I’m hoping you all can help me. When you get this bad & in so much pain, you hope for some help somewhere from someone who IS HONEST & has a heart.❤❤❤

    Thank YOU

    1. Chris Centeno, MD Post author

      I’m not sure we can help, but we do use real stem cells from your body and have real doctors who know what they’re doing. If you’re concerned about owing a bunch of money for something that won’t work, then don’t dig the hole deeper by falling for the Medicare amniotic fluid scam. You will eventually owe all of that money back to the provider once Medicare figures out they paid the provider in error that provider will be coming after you for the money.

  5. Vanessa

    Hi Dr centeno I went to you clinic for an evaluation everything went well, I need stem cell with bone augmentation . Can you explain what is bone augmentation and how will help in the arthritis knee. Thanks.

    1. Chris Centeno, MD Post author

      Already answered that one here:

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