COVID-19 UPDATE: Regenexx is committed to the health and safety of our patients. You may now be seen in clinic or via telemedicine for virtual/online or phone visits.
LEARN MORE
Our physicians are available via telemedicine to continue to give you the care you need during this difficult time. Learn more.

Mythbusters: Injecting Stem Cells IV Means Only 0.0005% Reach their Target in the Brain…

By /

As I have blogged before, many stem cell treatment centers around the world inject stem cells IV.  This makes sense, as it’s a very simple procedure with very few complications.  However, a bevy of recent studies have questioned the efficacy of this approach.  The problem is the “pulmonary first pass effect” which means that when adult stem cells are injected IV, about 95% get trapped in the lungs.  A recent study looked at how many actually ended up in the brain when injected IV.  Turns out a paltry 0.0005% or about 5 cells out of 1,000,000 injected ended up in the brain.  Here’s how it broke down.  48 hours after the IV injection of mesenchymal stem cells:

-Between 1.5 and 3.7% of the infused cells made it past the lungs

-0.295% of the cells made it to the carotid artery

– 0.0005% made it past the blood brain barrier and ended up in brain tissue

What does this mean?  It means that if you injected 100 million mesenchymal stem cells IV (a higher end dose), only 500 would end up in the brain.  Is this a lot of cells in the brain?  No, it’s so far below what the experimental models show would likely cause brain repair as to be insignificant.  As an example, 100 million MSC’s if stored in a semisolid state would be about the size of a pea.  500 MSC’s would be much much smaller than the head of the sharpest pin imaginable.

The upshot?  Real adult stem cell treatments aimed at treating a target tissue (like the brain) involve local delivery to the area.  While IV treatments may work for things like lung disease or general anti-aging, for fixing a specific damaged tissue this is not a viable treatment method.  It’s also important to note that other types of stem cells (outside of adult mesenchymal or heamtopoetic stem cells) may or may not suffer from this problem.  For examples, VSEL’s are known to be very small and they may escape this first pass effect in the lungs.

Get health and wellness information from a trusted source.

By submitting the form, you are agreeing that you read and consent to our Privacy Policy. We may also contact you via email, phone, and other electronic means to communicate information about our products and services. We do not sell, or share your information to third party vendors.

Is Regenexx Right For You?

Request a free Regenexx Info Packet

REGENEXX WEBINARS

Learn about the #1 Stem Cell & Platelet Procedures for treating arthritis, common joint injuries & spine pain.

Join a Webinar

RECEIVE BLOG ARTICLES BY EMAIL

Get fresh updates and insights from Regenexx delivered straight to your inbox.

Subscribe to the Blog

CONTACT US

9035 Wadsworth Pkwy #1000
Westminster, CO 80021
888-525-3005

FOLLOW US

Copyright © Regenexx 2020. All rights reserved. | Privacy Policy

*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.

LinkedIn
Email