It’s Ask Dr. C Time Again!

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Every so often I put out a request for great questions about stem cells and orthobiologics so that I can answer them in a longer format. It’s that time again, so please leave your questions below. Here’s a guide to help you know what I’m looking for:

  • The question should concern many people. For example, a question about whether bone on bone arthritis can be cured with stem cells will help many people understand what to expect from these procedures. However, a question about your personal candidacy for stem cells may or may not help others understand a topic.
  • Think about the common questions that you and others may have about joint or spine injuries or stem cells, exosomes, PRP, or other regenerative therapies.

Just leave your question in the comment section below!

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32 thoughts on “It’s Ask Dr. C Time Again!

  1. Alan

    What is the success rate for people 70 and over for hip stem cell injections? Is more than 1 injection required? I have had one hip replacement and would like to avoid another if possible.

    1. Chris Centeno, MD Post author

      I would need to look at your imaging, but if you’re “bone on bone” then you are not a candidate for this type of procedure.

  2. Janis Paquette

    Should PRP be repeated if there’s no pain? If so, how often?

    1. Chris Centeno, MD Post author

      See my Oct 11th post

  3. Margaret S caballero

    Two yrs ago I was in a MVA & had surgery on a torn minuses. I am in much worse pain. While in a great hospital I contracted 2 superbugs which has since caused life threatening/taking illness. I cannot walk w/o at times great pain nor can I straighten my knee. I’m used to being extremely active. Crazy but every night after sleeping 3-4 hrs my knee wakes me up w/ horrible pain. No one seems to have any answers. I believe the superbugs are looming in my damaged tissue. I would like to get your thoughts on whether stem cells injected into my knee could give new & bacteria free life into the tissue of my knee. Thank you.

    1. Chris Centeno, MD Post author

      Both PRP and bone marrow stem cells have been used as antibiotic treatment, so it’s possible these could help.

  4. Masuma Downie

    Could Dr. Centano tell us about the use of AOD9604(growth hormone peptides), and HA(hyaluronic acid).
    How effective is a combined injection of these for knee joint issues?

    1. Chris Centeno, MD Post author

      That hasn’t been used in humans and published, so unknown.

  5. Chris Anderson

    Do people with autoimmune syndromes respond differently to PRP? Autoimmune issues involve increased inflammation and my understanding is that PRP’s therapeutic response comes in part from a site specific increase in inflammation. So it seems possible that PRP could increase post treatment flare-ups, decrease PRP effectiveness or increase it’s long term effectiveness in people with autoimmune syndromes.

    1. Chris Centeno, MD Post author

      That’s not something we commonly see.

  6. Russ Delaney

    Can Regenerative medicine be of use to those patients who have already had total hip replacement?

    1. Chris Centeno, MD Post author

      Possibly. For example, many still suffer from hip tendon pain and this is something that can be targeted via ultrasound guidance.

  7. David Watson

    i am an active 76 years old and had my stem cells and PRP in both knees 3 years ago, and has helped 60%, is there any benefit to having the procedure again ? Procedure was in a Regenexx clinic.

    1. Chris Centeno, MD Post author

      Yes, likely, see my post from 10/11

  8. Lee

    When looking at a cervical spine MRI, how can you tell whether any of the ligaments are injured?

    1. Chris Centeno, MD Post author

      This was featured today in the Oct 12th blog post

  9. David Snyder

    Can PRP and/or stem cells prevent further cartilage loss as opposed to regrowing cartilage?

    1. Chris Centeno, MD Post author

      This was featured as the 10/11/20 blog post.

  10. Harris Kerr

    I read about a study of knee cartilage in mice. Study used a large number of micro fractures and three proteins. And the result was some cartilage growth. First comment on the study. Second I’d like to get in such a study for humans. Will you be doing this?

    1. Chris Centeno, MD Post author

      I have already commented on this here:

  11. Joe Walsh

    .Dr. C
    My fifteen year old grandson recently suffered a complete tear to his ACL, while playing basketball. Since I had great success with a PRP injection on my spine from one of your specially trained physicians, I recommended that my daughter take her son for an exam by another REGENEXX doctor. I thought that even if his knee required traditional surgery, a possible PRP injection would help speed the healing of the repaired ligament. However she was told that due to her son’s age (15), he was not a candidate. It is my thought that a young person’s cells and platelets would work even better than an older patient, since the young person’s body is in a growth mode to begin with. What am I missing or is it that the procedure has not been tested enough on young people. I thank you for your answer and am a firm believer in REGENEXX.

    1. Chris Centeno, MD Post author

      Joe, not sure who you saw, but that’s not accurate. I will reach out to you via email.

  12. Glenn Calzada

    You mention knee joint issues being treated but I’ve developed arthritis in my thumb joint. About two years ago I got a steroid injection in the joint and it helped reduced the swelling and the pain. But it’s starting to swell again and the pain is returning. I was told at the last injection about 9 months ago
    (the second shot) that it wasn’t beneficial to get another steroid shot. Would PRP treatment benefit me? Is there an alternative other than reconstruction, which I refuse to even consider?

    1. Chris Centeno, MD Post author

      We have good success treated the thumb CMC joint, see and

  13. Larry Starkes

    Can your clinic order MRI, CT scan or xrays before i come to the clinic? I have a arthritic ankle joint and had Regenexx stem cell treatment on my left knee joint which is doing very well.

    1. Chris Centeno, MD Post author

      Yes, that imaging script could be written during a telemed remote visit over zoom!

  14. Linda Hicks

    Hi Dr. Centeno, Here is an article about using the stem cells from the fat pad in the knee versus using bone marrow or adipose fat from the stomach or hip. What are you thoughts?

    1. Chris Centeno, MD Post author

      Robbing Peter to pay Paul. Meaning, you need all of those stem cells in teh fat pad to help keep your knee from degenerating. Hence, taking some of those to put into another knee creates an issue in the knee they were taken from…

  15. Steve Williams


    I have had L-5/S-1 disc and subluxation issues over the years, and I noticed that you folks treat some folks with these problems via platelet lysate injections, and certain other folks via multifidus injections. Roughly what conditions call for the one approach vs the other?


    Steve Williams

    1. Chris Centeno, MD Post author

      Usually, what you describe would warrant a DDD approach, see

  16. Katherine Barbieri

    My question is regarding the coccyx (Tailbone) Have you ever treated anyone for this type of pain relief. A hypermobile tailbone to be more specific. One of the segments slides out of place posteriorly.

    1. Chris Centeno, MD Post author

      Yes, we have treated many patients with an unstable coccyx.

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