Mesenchymal Stem Cell Research Continues To Increase

Short blog this morning. I’ve posted many times about how the year-over-year research on mesenchymal stem cells (MSCs) continues to increase. At some point, I expected this to level off, but that hasn’t happened yet. Let’s dig in.

What is a Mesenchymal Stem Cell?

If you’ve had a bone marrow concentrate procedure, this is believed to work through mesenchymal stem cells. In the same way, the procedure we perform through our licensed Cayman Islands site uses MSCs that are isolated and grown to larger numbers.

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What’s Published on MSCs?

If you don’t follow the peer-reviewed literature on MSCs, you might think we know very little about this topic. However, that’s not accurate. While new clinical studies are being published every day, we have a huge number of studies that are focused on the basic science of how these cells work.

The graph above looks at the number of publications per year on MSCs as listed in the US National Library of Medicine.

The graph above takes a different tack. This is how many total publications that are listed as of this morning in the US National Library of Medicine for MSCs and then common medications used daily in clinical practice. As you can see, when it comes to total publishing volume, we know more about MSCs than most commonly used medications.

all stem cell inforgraphic regenexx

Above is my annual list of clinical publications on all mesenchymal stem cells used in orthopedic clinical trials. Again, this increases every year as well. Click on that image to see the PDF with links for each study. This infographic is only up to 2021 as I have yet to finish the 2022 version.

The upshot? While more high-level clinical trials are needed, the publications on MSCs continue to increase year over year. In addition, we know quite a bit about this cell type. So the next time some uneducated physician tries to tell you there just isn’t enough research on this stuff, now you know that just isn’t true!

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications. View Profile

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NOTE: This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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