The Vagus Nerve, Neck Pain, Anxiety, Headaches, and Depression

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We’ve seen neck pain patients for years with lots of seemingly unrelated symptoms. Many have suffered from depression, anxiety, headaches, and some even cardiac problems like runs of tachycardia. So what’s causing all of this? Let’s delve into some new research on the vagus nerve.

vagus nerve and neck pain

We’ve seen neck pain patients for years with lots of crazy symptoms. Many are anxious or depressed and some have cardiac problems like runs of tachycardia. So what’s causing all of this? Let’s delve into some new research on the vagus nerve.

The Vagus Nerve

Not all who wander are lost and the vagus nerve—Latin for “wandering” nerve—keeps us found. The tenth of the twelve cranial nerves, the vagus nerve reaches from the brain into the far reaches of our body not unlike the root system of a tree. The longest, largest, and most complex of the cranial nerves, the vagus nerve influences symptom changes in all sorts of problems such as depression, migraines, epilepsy, inflammation, and arthritis, among others. In addition, stimulating the nerve with medical devices has been shown to be effective in treating many conditions (5,6)

The more we learn about this wandering nerve, the more we realize we need to know. For example, we know that by stimulating the vagus nerve we can treat depression. Further down, the system reaches the gut, and those with digestive issues and acid reflux are often found to have insufficient vagal activity. In between, the nerve’s activation or deactivation connects to the well-being of the heart, lungs, and immune system (2).

And while we still don’t know all that the vagus nerve does, we have come to understand that it is the Zen mediator of the parasympathetic nervous system—the laid-back sibling to the sympathetic system and its fight-or-flight response. Meaning that if the vagus nerve is working well, we can relax and become meditative. If it’s not working, then we become anxious and overstimulated.

The ‘wanderer’ controls our relaxation levels by slowing heart rate, switching off inflammatory responses, and initiating the release of calming chemicals (1). Enough activity can soothe an asthma attack or even an epileptic seizure. Incredibly, research shows that many conditions exacerbated by inflammation or stress can be helped by stimulating the vagus nerve. In fact, an entire medical device industry has sprung up around surgically implanted stimulators for the vagus nerve.

Historically, a surgical implant in the chest with a wire and lead that goes to the neck is used for stimulation of the vagus nerve. The idea is that by elctrically stimulating the nerve, we can treat patients whose nerve isn’t working well. In addition to implantable stimulators, there is a new treatment with FDA approval that employs a patch pressed against the neck to soothe migraines and cluster headaches (5). And now new research is underway into cures for mental health disorders such as depression (3). Meaning, when you control the vagus nerve, you control quite a bit about how a person feels on a day to day basis.

>> What Causes Cervicogenic Headaches?
>> Deep Neck Flexors and Chronic Headaches with Neck Pain

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The Chicken or the Egg-Crazy and Lazy

When doctors see patients with chronic neck pain, many aren’t sure how to interpret what they see. Many of these patients are anxious, depressed, and just a little “crazy”. In fact, when I was in training and then just beginning private practice, many of my colleagues thought most of these chronic neck pain patients were “crazy and lazy”. The lazy part came from the fact that many were made worse by traditional physical therapy and didn’t want to continue hurting themselves. For me, all of that changed after a key study was published that showed that if you got rid of their neck pain, these patients were no longer crazy, meaning that depression and anxiety went away (4). Meaning, that the study showed us that something going on in the neck was causing these symptoms. So patients weren’t crazy and lazy, they just had a neck problem. Could this be the vagus nerve?

Neck Pain, Headaches, and the Vagus Nerve

Where the Vagus nerve travels may explain why we see patients with lots of crazy symptoms. This includes depression, anxiety, and rapid heart rate (tachycardia). Why the rapid heart rate? The Vagus nerve acts as the brakes for the heart. So irritation of the nerve by surrounding muscles or bones can lead to inhibition of the nerve thus removing the brakes for heart rate, which means a faster heart. The nerve has also been implicated in headaches (7).

vagus nerve neck pain

Here we see the mid-neck (click on the image to see a bigger version). Note that the Vagus nerve is right behind the Sternocleidomastoid muscle (SCM) and right in front of the scalenes. What are some of the tightest muscles in the necks of patients who have had injuries like whiplash? The SCM and the scalenes. Hence, irritation of the vagus nerve by these structures may explain many of the symptoms we see in these patients. In addition, remember that the vagus nerve is “the wanderer”, so it goes lots of other places where it can get irritated or have pressure placed on it. Let’s explore some of those.

craniocervical instability

If we go back to the top, where the vagus nerve comes out of the skull, we can see why these same symptoms commonly plague patients with craniocervical instability (CCI). In the image to the right, you’re looking at the skull base as the dotted lines and the two circles are holes in the skull where the different nerves exit. The Foramen magnum is the big hole at the bottom of the skull where the spinal cord and nerves exit. The Jugular Foramen is another smaller hole where the spinal accessory nerve and the vagus nerve come out. In CCI patients, the skull is not stable on the neck. So these nerves are bound to get yanked around more, leading to irritation and vagus nerve dysfunction. In addition, the spinal accessory nerve also goes to the SCM and upper trap muscles, which are also muscles that are commonly tight in these patients. Meaning an irritated nerve can cause a tight and irritated muscle.

vagus nerve and cci

Let’s also take a look at the proximity of the vagus nerve to the atlas, which is C1. In the diagram I created to the left, note that the vagus nerve exits that jugular foramen and then travels right over the side of the atlas (C1 highlighted in yellow).  In patients with CCI, C1 is often unstable in a side to side direction, which can be seen as too much C1-C2 overhang on a DMX study. Hence, the vagus nerve can be bagged in more than one spot in CCI patients. So is it any wonder that many have rapid heart rate? Or anxiety? Or depression? Their vagus nerve is getting yanked something fierce every time they move their neck and head.

The upshot? The vagus nerve is responsible for lots of stuff in our bodies. If it works well, it helps us relax. If it doesn’t, we can get a rapid heart rate, anxiety, depression, and a host of other issues. This nerve is also likely responsible for many of the symptoms that neck pain and CCI instability patients suffer. Hence, they’re not “crazy or lazy”, their vagus nerve is just really messed up!



(1) Keltner, Dacher. Secrets of the Vagus Nerve. Greater Good Magazine. The Science of a Meaningful Life video series. July 2012.

(2) Yuan H, Silberstein SD. Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part I. 2016 Jan;56(1):71-8. doi: 10.1111/head.12647.  [PubMed] / [Google Scholar]

(3) Lv H, Zhao YH, Chen JG, Wang DY, Chen H. Vagus Nerve Stimulation for Depression: A Systematic Review. Front Psychol. 2019;10:64. Published 2019 Jan 31. doi: 10.3389/fpsyg.2019.00064. [PubMed] / [Google Scholar]

(4) Wallis BJ, Lord SM, Bogduk N. Resolution of psychological distress of whiplash patients following treatment by radiofrequency neurotomy: a randomised, double-blind, placebo-controlled trial. Pain. 1997 Oct;73(1):15-22. [PubMed] / [Google Scholar]

(5) Johnson RL, Wilson CG. A review of vagus nerve stimulation as a therapeutic intervention. J Inflamm Res. 2018;11:203–213. Published 2018 May 16. doi: 10.2147/JIR.S163248. [PubMed] / [Google Scholar]

(6) Thayer JF. Vagal tone and the inflammatory reflex. Cleve Clin J Med. 2009 Apr;76 Suppl 2:S23-6. doi: 10.3949/ccjm.76.s2.05. [PubMed] / [Google Scholar]

(7) Lendvai IS, Maier A, Scheele D, Hurlemann R, Kinfe TM. Spotlight on cervical vagus nerve stimulation for the treatment of primary headache disorders: a review. J Pain Res. 2018;11:1613–1625. Published 2018 Aug 27. doi: 10.2147/JPR.S129202. [PubMed] / [Google Scholar]

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27 thoughts on “The Vagus Nerve, Neck Pain, Anxiety, Headaches, and Depression

  1. Stacey Kaufman

    I have long suspected vagus nerve compression(s) since my car accident.
    Symptoms that come and go:
    Deep raspy voice
    Digestive distress
    Feeling jumpy/anxious
    Thank you for this post!


    How do you know that the neck pain is not coming from a torn rotator cuff. I am plated C3-4-5-6
    That was 3 surgeries from 2010 to 2013. Then in 2015 I had 4 rotator cuff repairs on my left and 1 on my right. all this took place in 15 months. So now Jan 2020 Neck MRI looks fine. So then went to shoulder DR.
    I am told I have torn my left again . I won’t do a reverse shoulder. The problem is I am in terrific pain all the time in the neck. The 2 steroids shot are not working.
    I am still working and I find it is very hard to do my job.
    So could the shoulder pinch the vagus nerve ?

    1. Regenexx Team

      Hi Starr,
      Fusion usually causes something called Adjacent Segment Disease, which we treat regularly. Please see: and and We’d need to see the images and examine you to see what’s going on in your case and see if we can help. To do that please use the blue Candidate button here:

  3. Tina

    Great information. Thank you. Is the only fix for stimulation an electrical implant and would an under stimulated vagus nerve cause TOS symptoms? It seems it could be interrupted by a variety of musculoskeletal problems.

    1. Regenexx Team

      Hi Tina,
      It depends on the cause. As it says in the blog, a common cause is CCI, or Craniocervical Instability, which we have developed the first nonsurgical procedure to treat. Please see:

  4. Jack Bee

    This article describes almost exactly many symptoms that were occurring. Getting out of the shower in the mornings after a strenuous workout and my heart would start to race, always after a certain movements. Same racing, only after reaching down into my chest freezer. Many inconsequential movements end up with a racing heart with no exertion while digging a large hole into heavy clay would not. Often standing up straight, rolling my shoulders back and stretching for the floor would slow my heart quickly. I had a whiplash car accident 25 years ago and therapy to alleviate symptoms. This article rationalizes so many items including my ever increasing anxiety attacks. Thank-you.

  5. Gerald Turpin

    My neck hurts if I try to stretch it. There’s a constant minor pain. When I drive for over a distant of 10 or more miles I get a severe pain going down and to the right side of my spine and in between my shoulder blades. If I try to relax and rub that area I get more severe pain. The pain subsides some after I am no longer driving for about an hour but is still noticeable and seemingly back to the lower neck. I know a lot of t is related to tension while driving, but can’t escape the pain no matter how I try. Is there help for me? Is this Vagus Nerve symptoms?

    1. Regenexx Team

      Hi Gerald,
      many different things could be going on there. We’d need more information, and to examine you to determine what’s going on in your case. To do that, please use the Candidate button here:

  6. Olivine thomas

    Great information thank you

  7. Suzanne Schmitz

    Can you help with problems with the vagus nerve? I had a cervical fusion in 2008, have had so many problems since.

    1. Chris Centeno, MD Post author

      You may want to try an IPA physical therapist:

  8. John

    Thanks for covering this Centeno. It does get to the point where it seems when you have only gone backwards in health trying to exercise, that it becomes very anxiety inducing to exercise.

  9. Andy

    Omg. You may have saved my life. Whoop knew!!!! Thank you so much for writing this.

  10. JO

    Functional Manual Therapy… thank u so much for bringing this treatment to my attention.

    After an auto accident in 2005 I have been battling Vagus/heart issues. Working in the health field I have stayed away from meds & crazy MDs. I used healthy diet, massage, acupuncture, acupressure, chiropractic and natural oils on my body to heal/repair. Today I am left only with this AFib issue with certain movement, which I believe is coming from my neck/impingement? Vagal symptoms with moving left arm (left body impacted from accident), reaching, bending. I will be looking for a Functional Manual Therapist! Thanks so much. — Jo/N GA

  11. Penelope J. Chisholm

    Can the vagus nerve be implicated in bradycardia? In the last 2 years I awake from sleep, sometimes lying down, sometimes in a recliner, with both my arms “asleep” right down to ends of my hands. I also have developed a very slow heart rate which is consistently at 38-44 beats per minute and often erratic. I have a feeling it has to do with my cervical area, however, I have absolutely no pain anywhere.

    1. Chris Centeno, MD Post author

      Yes, it can be implicated in bradycardia. You may want to get that checked out as a heart issue first and then if nothing, find a Regenexx provider above.

  12. Bea

    These are exactly the symptoms I have and that doctors don’t seem to take for serious when I attempt to explain them. What is the treatment for it?

    1. Chris Centeno, MD Post author

      That all depends on the cause of teh vagus nerve issue. You may first want to seek out an IPA PT, see

  13. Todd

    Three years ago I was diagnosed with third-degree heart block at 41 years old. I had no history of heart issues and my cardio had no explanation. The only option was a pacemaker. The block is now intermittent and I can feel when I’m paced. Most commonly, this occurs when I’m reaching up or leaning against my left arm. In fact, I can induce it practically any time sitting propped on my left arm. I explained this to my physicians and they don’t seem to think it relevant. Could the vagus nerve be involved in heart block?

    1. Chris Centeno, MD Post author

      Yes, that could be.

  14. Melissa North

    I’ve been recently diagnosed with a stomach ulcer, ( now on medication) . Have neck stiffness, dull ache/ pain over right eye, (nausea), dizziness and balance issues ( and anxiety and stress due to real personal issues). Often a feeling of spinal compression when sitting upright, resulting in a feeling of lightheadedness and a need .to take in ‘air.’ Can the Venus nerve be responsible for these symptoms. And, how does this all mend? A great article!

    1. Chris Centeno, MD Post author

      There is no way to tell without a diagnostic work-up. Given your symptoms, something to research would be craniocervical instability.

  15. Jessica Y

    I have thought that I have a messed up vaguel nerve as i suffer from sever neck pain, shoulder pain, upper back shoulder blades arm pain, headaches , eye pressure etc. I do have chiari malformation as well as cervical syringomyelia (c2-c7). I get crazy symptoms, every day is different I will get numbness in my face, arms, legs neck and back or even my nail beds. I have severe anxiety due to all these issues. Never believed anxiety was anything that could change ur life until I started having medical issues. I have that I might have CCI but I’m dealing with doctors that think I’m crazy. I have been to the Er several times because I get chest pressure then radiates to my arm or my face or neck or right side or left side goes numb or bouts of tarchacardia I get the “your anxious” response. Well I’m anxious because I have all these crazy symptoms where the doctors I see don’t look for the root cause. I have researched slot abd even try to point the doctors into the right direction to help me but they are to prideful. Could these symptoms be a result of this?

    1. Chris Centeno, MD Post author

      Yes, getting a diagnosis like CCI could tie many of these symptoms back to vagal nerve irritation. However, only a handful of physicians have any expertise in making that diagnosis. I would encourage you to get an appointment at our Colorado clinic.

  16. Simon

    Hi I’m a 48 year old male ex military and believe my nerve was damaged by the anti malaria drug lariam in the early 90s
    Anxiety, panic attacks, heart palps and flutters nearly all the time but heart function is not is normal on echos and ecg, stomach issues… loose stools or constipation.. wind…nauseous, light headed, muscle aches in jaw and backs of my legs,, right side abdomen pain not extreme but it’s there! Horrible metallic taste in mouth… sounds horrible and yes it’s sometimes unbearable but thankfully I do have periods of very few symptoms just right side pain and belly issues…
    diagnosed with duodenum inflammation severe… acid reflux damage… enlarged spleen.. slight.. and when I’m in a flair up I feel generally unwell but bloods are normal…. I’m sure the doctors don’t know what to do with me🙄 the trouble is I know what caused this but it’s trying to convince the so called professionals it’s Vegas nerve damage

  17. Sonia Ulibarri

    Hi my name is Sonia im not sure what my issue us but i have a tense neck rapid heartbeat anxious my stomach n legs n veins get very swollen . im dizzy shortness of breath n over all feel horrible. I’ve gone to hospital n they sent me home with anxiety . they did run a dye though my bodyfi
    For clots. He thought i had one on lung but said it was axiety n sent me home. Im still feeling bad n because of covid there not really accepting appointments exept in ER. Please give me advice if u can

    1. Chris Centeno, MD Post author

      Sonia, it sounds like a telemedicine consult would the next best step.

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