PRP vs. Kobe’s Regenokine: Which is better for knee arthritis?

By /

Receive a Regenexx® Patient Info Packet by email and learn why it's a superior regenerative solution.

PRP vs. Kobe's Regenokine

Is Kobe’s knee therapy really worth it?  Last year I blogged on Regenokine, a simple conditioned serum therapy for arthritis. It”s also is called Orthokine in Germany or IRAP by many vets I know.  Basically, it’s  similar to Platelet Rich Plasma (PRP) therapy where the patient’s red blood cells are taken and separated from the serum (see above). However, unlike PRP, where the fraction of the blood containing serum and platelets is concentrated and immediately re-injected, the Orthokine process cultures the serum with etched glass beads so that white blood cells produce a natural anti-inflammatory called IRAP. This therapy has been all over the news lately as several big name athletes traveled to Germany to get the therapy (Kobe Bryant). However, what’s the reality versus the hype of PRP vs. Kobe’s Regenokine?  Last year I compared the published research on Orthokine versus research published on PRP. Suffice it to say that Orthokine lost badly in a head to head comparison to PRP for treating mild knee arthritis. I’ve since had several people complain that all of the scientific graphs were difficult to understand in that post, so I decided to explain it in a different way:

PRP vs. Kobe's Regenokine

Above is one of the graphs that I used in my last Orthokine blog. I’ve isolated the bars that represent what knee arthritis patients reported at 6 months after their 6 Orthokine shots in a paper published by the German inventor of the technique. I’ve labeled this section of the graph so you can better understand what it says. In this case, since the height of the bar equals how much improvement the patients reported, note that Orthokine is barely taller than the fake placebo treatment (which represents doing nothing at all). In other words, if you did nothing for your knee arthritis versus getting an Orthokine shot, at 6 months after the procedure, it’s unlikely that on average you would notice a difference. So why all the Orthokine hype? Good question-as it’s not supported by the science. I think it’s because our 24 hour news cycle has compromised the ability to deeply investigate medical stories. How has Orthokine gone to the dogs? I recently learned that the clinics using Orthokine here in the US (where this would be classified as a drug requiring a drug approval due to our crazy over-regulation in this space) are using Veterinary kits designed for dogs, cats, and horses on human patients! This therapy has been renamed “Regenokine”. How good is Orthokine compared to the simple PRP shot that Kobe could have gotten down the street for about $1000 versus the 7-8K he paid in Germany (not including the private jet charter which is likely another 30K)? I came up with a “value index” for patients with mild knee arthritis by using the results from the Filardo and Kon studies mentioned in my last blog. I took the cost of the 3 PRP shots used in these studies (about $1,000 a piece or less) and divided by the amount of improvement reported by patients 1 year after the shot (approximately 47%). This came out to $64 for every percentage improvement reported by the patient. I then took the cost of Kobe’s shot at 8K (leaving out the private Jet) and did the same calculation. This came out to a whopping $421 for every one percent improvement (largeley because there was such anemic improvement reported by these patients in the Orthokine study). The upshot? If you have mild knee arthritis, while following Kobe to Germany or getting treated with a dog kit here in the U.S. might be tempting (or maybe not), you’d be much better off finding a good PRP doctor to inject your knee. The answer to PRP vs. Kobe’s Regenokine is neither therapy are good at treating moderate or severe arthritis.

Category: Knee, Latest News

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
View Profile

Get Blog Updates by Email

Get fresh updates and insights from Regenexx delivered straight to your inbox.

Regenerative procedures are commonly used to treat musculoskelatal trauma, overuse injuries, and degenerative issues, including failed surgeries.
Select Your Problem Area
Shoulder

Shoulder

Many Shoulder and Rotator Cuff injuries are good candidates for regenerative treatments. Before considering shoulder arthroscopy or shoulder replacement, consider an evaluation of your condition with a regenerative treatment specialist.

  • Rotator Cuff Tears and Tendinitis
  • Shoulder Instability
  • SLAP Tear / Labral Tears
  • Shoulder Arthritis
  • Other Degenerative Conditions & Overuse Injuries
Learn More
Cervical Spine

Spine

Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Knee

Knees

Knees are the target of many common sports injuries. Sadly, they are also the target of a number of surgeries that research has frequently shown to be ineffective or minimally effective. Knee arthritis can also be a common cause for aging athletes to abandon the sports and activities they love. Regenerative procedures can be used to treat a wide range of knee injuries and conditions. They can even be used to reduce pain and delay knee replacement for more severe arthritis.

  • Knee Meniscus Tears
  • Knee ACL Tears
  • Knee Instability
  • Knee Osteoarthritis
  • Other Knee Ligaments / Tendons & Overuse Injuries
  • And more
Learn More
Lower Spine

Spine

Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Hand & Wrist

Hand & Wrist

Hand and wrist injuries and arthritis, carpal tunnel syndrome, and conditions relating to overuse of the thumb, are good candidates for regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Hand and Wrist Arthritis
  • Carpal Tunnel Syndrome
  • Trigger Finger
  • Thumb Arthritis (Basal Joint, CMC, Gamer’s Thumb, Texting Thumb)
  • Other conditions that cause pain
Learn More
Elbow

Elbow

Most injuries of the elbow’s tendons and ligaments, as well as arthritis, can be treated non-surgically with regenerative procedures.

  • Golfer’s elbow & Tennis elbow
  • Arthritis
  • Ulnar collateral ligament wear (common in baseball pitchers)
  • And more
Learn More
Hip

Hip

Hip injuries and degenerative conditions become more common with age. Do to the nature of the joint, it’s not quite as easy to injure as a knee, but it can take a beating and pain often develops over time. Whether a hip condition is acute or degenerative, regenerative procedures can help reduce pain and may help heal injured tissue, without the complications of invasive surgical hip procedures.

  • Labral Tear
  • Hip Arthritis
  • Hip Bursitis
  • Hip Sprain, Tendonitis or Inflammation
  • Hip Instability
Learn More
Foot & Ankle

Foot & Ankle

Foot and ankle injuries are common in athletes. These injuries can often benefit from non-surgical regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Ankle Arthritis
  • Plantar fasciitis
  • Ligament sprains or tears
  • Other conditions that cause pain
Learn More

Is Regenexx Right For You?

Request a free Regenexx Info Packet

REGENEXX WEBINARS

Learn about the #1 Stem Cell & Platelet Procedures for treating arthritis, common joint injuries & spine pain.

Join a Webinar

RECEIVE BLOG ARTICLES BY EMAIL

Get fresh updates and insights from Regenexx delivered straight to your inbox.

Subscribe to the Blog

FOLLOW US

Copyright © Regenexx 2019. All rights reserved. | Privacy Policy

*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.

LinkedIn
Email