Need a Supplement for Cartilage Protection and Support? Make Sure It Has Resveratrol

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supplement for cartilage protection

If you are taking a stem cell supplement for cartilage protection or arthritis, it’s a good idea to make sure it contains high-quality Resveratrol. Why? A number of studies suggest that Resveratrol protects cartilage cells, and cartilage loss or damage leads to arthritis. A good stem cell supplement with Resveratrol is designed for people who have joint pain and are looking for a natural, nutritional supplement to help support their joint health.

What Is Resveratrol?

Resveratrol is a naturally occurring antioxidant found in red and purple grapes; red wine; peanuts; some roots, such as knotweed; and some berries, such as cranberries and blueberries. Resveratrol defends against the stress of invading bacteria and other microbials. Resveratrol has gotten quite a bit of notice lately because it seems to help people keep a healthy blood sugar, and rats fed the compound live longer than their peers. Other benefits of Resveratrol studies seem to support include some protections from high blood pressure, heart failure, heart disease, and skin cancer and support for the nerves and brain.

Resveratrol has become famous for activating the SIRT-1 gene (see this study and this study), which is associated with the beneficial effects of fasting. You may have never heard about the SIRT-1 gene, but you’ve likely seen stories about primate life extension.

In addition, since Resveratrol is found in red-grape skins, many scientists have proposed it could be the reason our red-wine drinking cousins, the French, seem to live longer than we Coke-drinking Americans. SIRT-1 is also activated by the Resveratrol in red wine, which may explain why people who drink red wine seem to live longer and have less heart disease.

Research also shows this SIRT-1 gene has a healthy impact on our cartilage.

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Resveratrol in the Diet May Not Be Enough

While you may get some Resveratrol through foods you consume, it’s nearly impossible to get the amount you would need in order to mine its health benefits to cartilage through food alone, especially if you’ve already experienced some cartilage loss or damage. It’s not unlike a climber summiting Mt. Everest. A wise climber knows the air at that high altitude isn’t the norm anymore—it won’t be sufficient. The climber will need to supplement by breathing high-pressured oxygen through masks to keep his or her body healthy and functioning appropriately.

When you’ve already experienced some cartilage loss or damage, or even if you just have many years of wear and tear, it’s not the norm anymore, and it’s time to make wise choices to keep your body healthy and functioning appropriately. One of those wise choices, based on the published science to date, is to make sure your stem cell supplement contains Resveratrol.

What Is Cartilage, and How Do I Keep It Healthy?

Cartilage is a firm, flexible cushion for a joint that covers both ends of the bone and provides a smooth surface with little friction. It helps our joints move easily and comfortably. When you lose or damage cartilage from a joint like the knee, this is one definition of arthritis.

What can you do if you want to improve your cartilage or keep your cartilage healthy ? After reading many research studies in this area, if you have healthy cartilage, I believe moderate exercise will keep it healthy—healthier than no exercise. If you have bad cartilage or an injury, then moderate exercise may or may not help. In that case, biologic treatments like stem cells or platelets may help. While a supplement with resveratrol is important for cartilage health and stem cell support, supplements such as glucosamine and chondroitin may also be something to consider, as many objective MRI studies do show that for patients with cartilage concerns, certain supplements help to maintain cartilage health.

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How Does Resveratrol Work as a Supplement for Cartilage Protection?

One study shows the SIRT-1 receptor is expressed on cartilage cells to keep them healthy. As we age, the SIRT-1 gene gets stimulated less and less, which then results in the cartilage cells becoming less stable, prompting them to produce less of the chemicals that help to absorb pressure, likely leading to osteoarthritis. What’s also fascinating is that the SIRT-1 gene activation is also lessened by diabetes and insulin signaling, so diabetics and patients with syndrome X, or metabolic syndrome, have shorter life spans and more knee arthritis. This is why it is so important that we continue to stimulate our SIRT-1 gene as we age by getting enough resveratrol to benefit our cartilage.

Another study used some fancy tools to measure the properties of cartilage at the “nano-level”, including atomic force microscopy (ATM). This tool can not only image things at a nanometer scale (like a tiny cell) in 3D, but it can also apply tiny forces as if you were pushing on the cells to make sure they were still pliable. In the study you will see images of a normal cartilage cell, a dying cartilage cell exposed to toxic chemicals, and a Resveratrol-treated cartilage cell exposed to the same toxic chemicals.

resveratrol a supplement for cartilage protection

The results? Normal cartilage cells are small, tight, and round, and at a nanoscale, this translates to a smooth surface. Dying cartilage cells exposed to cell-killing toxic chemicals appear large and blistered, and at a nanoscale, this translates to a rough surface. Resveratrol-treated cartilage cells exposed to the same cell-killing toxic chemicals have a smooth surface, calm and flat like a still lake; this translates to cartilage cells protected from the chemicals. Resveratrol also protected the outer covering of the cells (cell membranes), the cell elasticity, and the cell skeleton.

Stem Cell Supplement with Resveratrol

Since we know resveratrol activates the SIRT-1 gene, getting enough Resveratrol as we age is imperative to providing those necessary health benefits to our cartilage. Adding a good high-quality stem cell supplement with resveratrol is a good way to meet these needs.

To create the our stem cell support formula, we tested many different supplements in the lab against human stem cells, and Resveratrol performed very well, so we included it our proprietary formula. Research continues to support that the compound helps cartilage cells, a constant issue for patients with arthritis.

The upshot? Since a number of studies have shown that Resveratrol is a effective supplement for cartilage protection, we recommend it to our patients with arthritis. In addition, we were so impressed with its stem cell support function in our own lab tests that we included a high-quality resveratrol in our Regenexx Advanced Stem Cell Support Formula. So if you have arthritis or are in the early stages of it, or even if you just have many years of wear and tear and want to start protecting your cartilage, you’re no longer functioning in the norm, and it’s time to make that wise choice. You may want to consider a stem cell supplement with high-quality Resveratrol!

This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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24 thoughts on “Need a Supplement for Cartilage Protection and Support? Make Sure It Has Resveratrol

  1. Lee Hoepfinger

    What daily dosage of reservatol–other than red wine- is recommended?

    1. Regenexx Team Post author

      500mgs, twice a day.

  2. Dawn Darling

    Is this in your supplement juice you sell for stem cells?

    1. Regenexx Team Post author

      Yes! We spent a year of lab research determining the most effective supplement ingredients for stem cell health and cartilage support and their optimal ratios:

  3. Barbara Smith-Gibson

    What is the price of your supplement?

    1. Regenexx Team Post author

      There are a few different ways to purchase. Here is the link with all the info on pricing, etc.:

  4. Barbara

    Although you list the ingredients in your Joint Supplement , the amount of Reservatol is not stated. It just lists it as an ingredient. Since I am already taking Glucosamin/chroindroiten, curcumen , Vitamins C and D from the Ared 2 and Multivitamins I take, and Omega 3-6-9, I need to know this amount so that I can add this.

    1. Regenexx Team Post author

      500mgs twice a day.

  5. Dennis

    Say you have a relatively small cartilage defect in a weight-bearing (non-knee) joint that you don’t want to get worse, would this help…and most importantly would you have to take this forever? Or could you take it for a 1-2 months or so — or intermittently — to see how it works? Your product seems worthwhile, but $98 a month is expensive. Thanks.

    1. Regenexx Team Post author

      The Advanced Stem Cell Support Formula was designed as a support for our patients post procedure, and for anyone who wants to support their joint health and functioning. In Regenexx laboratory studies, the supplements used in this formula helped to maintain the health of the cell environment and provide support for the joint’s natural cartilage growth (chondrogenesis) process. 3 months would be a good trial to see if it helps with pain and function. The cost is actually less than the cost of the ingredients of the same quality, individually. Generally, for an existing cartilage deficit, stem cells would be prescribed.

  6. Beatriz Santiago

    Do you ship OUS?

    1. Regenexx Team Post author

      No, not at this time. Would you like to be contacted if that changes?

  7. Venetta

    I love what you guys are up too. This kind of clever
    work and reporting! Keep up the wonderful works guys I’ve added you guys to my blogroll.

    1. Regenexx Team Post author

      Thanks Venetta!

  8. Eric

    So I bought the supplement and was wondering how I can make it more bearable to take. Do you guys add it to anything or do you just drink it plain?

    1. Regenexx Team Post author

      It tastes so much better than the previous powdered version! It’s fine to mix with fruit or vegetable juice, or really anything that works for you. What lot of people do to make sure they get the whole dose is drink it down in one gulp, like you would a shot of wheat grass, and follow it with something tasty.

  9. Dee Higgins Mueller

    I find I feel rather warm following taking this liquid supplement, and sometimes a tad nauseated. Might that be the curcumin and pepper within the ingredients? How long should i take this before noticing any changes? It isn’t a pleasant experience drinking this stuff – taking it in a single gulp and not thinking about it works best, lol! It is expensive!

    1. Regenexx Team Post author

      It tastes so much better than the powdered formula that preceded it! That said, it is not delicious. It might be the curcumin or the pepper, and mixing it into something might help. Given the ingredients, it tends to mix better with savory things like V8 juice or the organic version, so you might try mixing the dose into a small glass of that type of thing. A good trial period would be 3 months.

  10. Mike

    I’m considering getting the Regennex stem cell therapy for an arthritic knee. I have two questions:
    1. How soon post-procedure would a patient start taking your Advanced Stem Cell Support Formula?
    2. What supplements do you recommend pre-procedure?


    1. Regenexx Team Post author


      We suggest that patients take the Regenexx Stem Cell Support Formula before and after the Procedure. In addition the Curcumin/Turmeric Complex and the Fish Oil are helpful as well. The Stem Cell support formula is the result of a year’s worth of research in our lab. The Curcumin and Fish oil, as long as the ingredients and ratios were the same you could get at any reputable health food store. Please see:

      1. Mike

        Thanks for the feedback!
        So is it OK to take the fish oil prior to the Regennex procedure or do I need to stop?

        I ask as I’ve read where other clinics want you to stop taking it a week prior to the procedure because it thins out the blood. I don’t seem to have any problems clotting when I get a papercut so I’m thinking I’ll be OK. I just don’t want the fish oil to inhibit the stem cell recovery process. If that’s not a problem, I’ll continue to take it as well as your Advanced Stem Cell Support Formula.

        1. Regenexx Team Post author

          No need to stop before Regenexx procedures. It needs to be in the correct ratio which is 1000 mg of EPA and 500 mg of DHA.

  11. Zach

    I just had the Regenexx stem cell same day procedure done and I want to start taking this supplement. Is it best to start taking the supplement immediately after the stem cell procedure, or is it better to wait a couple of weeks? If so, how long should I wait before taking it?

    The reason I am asking is that I was told by the surgeon to avoid all anti-inflammatories and I know that some of these compounds are anti-inflammatory.

    Any advice is much appreciated.

    1. Regenexx Team Post author


      We recommend that our Regenexx SD patients begin taking it immediately. Both over the counter and prescription NSAIDs need to be completely avoided for that reason. However, everything in the Advanced Stem Cell Support Formula was specifically designed by a years worth of our Lab’s research to support stem cells. Please see: You can also get it on Amazon.

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