Why Is My Calf Muscle Twitching?

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Maybe watching your favorite show on TV or browsing the Internet, and suddenly you experience a spontaneous episode of calf muscle twitching. Or perhaps, like what happens with me on occasion, you’ve just finished an intensive round of exercise, CrossFit for example, and that exertion is followed with some calf muscle twitching. Has this ever happened to you? I know it well, and it can certainly be concerning. So what causes your calf muscle to twitch or jump, and should you be worried about it if it’s a consistent occurrence? Believe it or not, the answer can often be found in your low back.

The Spinal Nerves Are the Middleman

The spinal nerves transmit signals from your brain that tell your muscles to contract. So the spinal nerves are the middlemen that connect the brain to the rest of the body and vice versa. When those signals become disrupted for some reason, or there is irritation to the nerve, this can cause parts of your muscles to twitch (the medical term for “twitch” is fasciculate).

The body is one big connected machine (the knee bone is connected to the ankle bone and so on), yet the medical industry has broken us down into component parts by treating the body by each section rather than as a whole. To effectively treat a patient, we need to treat the body as the whole unit that it is, and the spine is a good example of this. For one fascinating example, we can look all the way down to the foot—bunions. Bunions are more than just bunions, yet an orthopedic surgeon will “fix” them surgically by removing them. Bunions, however, can be caused by nerve irritation in your low back, so if the root cause isn’t also addressed, more problems are likely to follow. This is an example of only treating the sign (the bunion) of a much bigger problem (the spine issue that resulted in the bunion) and not considering the body as a whole.

Likewise, calf muscle twitching can be the sign of a bigger problem: a problem in the low-back spinal nerves.

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Calf Muscle Twitching: The Low Back and Calf Muscle Connection

The nerves that branch off of your spine in your low back connect to the muscles in the legs. Specifically, with the calf muscle, we are looking at nerves from about the L5 (fifth lumbar-level vertebra) to the S2 (second sacrum-level vertebra) as it’s the S1 and S2 nerves in the spine that usually supply the calf muscle. When there is a problem in this area, such as a pinched nerve or bulging disc, this irritates the nerve and can cause calf muscle twitching.

So do you need to do anything about it? Yes, you should have your low back checked. The calf muscle twitching may be your first sign that there is a problem, and tracking it down as early as possible and addressing the problem if there is one will assure that no further damage is done. You might ask, but wouldn’t my back hurt if I had a pinched nerve or a problem with a disc? Maybe or maybe not. Your back may or may not be stiff or sore yet because, as I mentioned, the calf muscle twitching can be the first indication that something is wrong.

This low back and calf muscle connection is so important that the damaged nerves in this area of the low back can lead to calf tears. This happened to me, and one of my warning signs leading up to my calf tear was twitching and jumping in my calf muscle. Incidentally, while I did have some mild low back pain once in a while, it was rare. The nerves are so imperative to our calf muscles (and this is true for any of our muscles throughout our body) that if the nerves stay damaged long term, this can even cause shrinkage and eventually atrophy of that calf muscle.

So what if you have your calf muscle twitching checked out and find that you do indeed have an irritated nerve in your low back? Then what? First, your irritated nerve can usually be helped with either physical therapy or the injection of fourth-generation platelet lysate, which is growth factors isolated from your own blood platelets. Next, be sure to pat yourself on the back because you’re ahead of the game, and treating it now could save you further damage down the road.

This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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Category: Spine

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35 thoughts on “Why Is My Calf Muscle Twitching?

  1. George Hillenbrand

    I add twitching after I got off work when I was younger, it turned out to be CMT.

    1. Regenexx Team Post author

      How are you doing now?

  2. chris

    Is there a point where a nerve stays damaged for long term that it can’t be turned back on with a platelet lysate injection?

    1. Regenexx Team Post author

      I think PL works better when there is nerve irritation or scarring around a nerve, but not as well once nerve axons have died off.

  3. Chad Freeman

    I have been going through this for a year, finally got an MRI to confirm the s1 nerve is irritated. It has been getting better slowly over months with physical therapy. Instead of my calf re-tightening in a day it now takes roughly a week. So I get on the slantboard religiously and keep biding my time.

    I was offered a right L5 TFE with corticosteroid for the nerve. Should I hold out for platelet lysate? How is one better than the other?

    1. Regenexx Team Post author

      There is a drastic difference. Platelet Lysate is regenerative, https://regenexx.com/blog/what-is-platelet-lysate/ , where as the same injection containing steroids breaks down cartilage, can damage tendons and is lethal to stem cells. https://regenexx.com/blog/steroid-injection-risks/ and https://regenexx.com/blog/new-research-steroids-hammer-stem-cells/

      1. Chad Freeman

        Chris, how often in your practice does the platelet lysate work to stop the calf twitching specifically, I have seen the spine PL pain charts. But I really don’t have pain so much as a twitching slowly tightening calf muscle. I had an EMG today and they said it wasn’t anything “acute” however it was something that I would have to live with and maybe it would heal. Has there been cases where you healed this condition?


        1. Chris Centeno Post author

          Chad, it just depends on the cause of the S1 nerve root irritation. I have this very issue and when I get S1 epidurals with platelet lysate it goes away until I do something to irritate that nerve (for about a year at a time). However, I have some severe chronic low back issues. In a patient with lesser issues, it may be cured.

          1. Chad Freeman

            So I got the flu, and ended up getting a steroid shot (in the glute) and it went away for a week or two. I have been doing a ton of PT and weight loss (-115lbs in a year) and it has helped but I can just tell one calf dorsiflexes better than the other. Basically (when it was bad) if I plantarflexed the right foot the calf “locks” and I have to force it back down. That has gotten better over time with the PT and dry needling and slant boards for days.

            How long after a steroid shot in the glute would you wait to get PL treatment?

          2. Regenexx Team Post author

            You’d need to wait 6 weeks between the steroid shot and a PL procedure.

  4. Brian C Bumgardner

    I believe I am currently experiencing this right now. I had spinal surgery just over a year ago. The past week or more has been hell in that my calves won’t take a break. They always feel like they’re constricting or “jumping” around. What is my next move?

    1. Regenexx Team Post author

      Unfortunately, spine surgery in any area of the spine is damage to accomplish a goal. Please see: https://regenexx.com/blog/spine-surgery-damage-accomplish-goal/ We’d need to examine you to see what’s going on in your particular case. Please call 888 684 9919 or submit the Candidate form if you’d like us to weigh in.

  5. Susan Gonzez

    I have had 3 back surgeries, last one in 2008. I still have chronic back pain. I just woke up with cramp in my calf and now both are twitching and jumping around. Quite strange to see really. If I don’t have my feet flat on the ground and try to lay back down I’ll start getting the cramps again in my calf.
    I don’t want anymore back surgery, because in some ways I have diff pains than before surgery. Some issues got better, but then it created new problems. I belive the screws in my back possibly. Would I still be a good candidate for what you are talking about, and will my back doctor of 10 years know what it is? Thank you

    1. Regenexx Team Post author

      We’d need to examine you to answer that question. The areas most commonly associated with Calf twitching are S1 and S2 and could easily be affected by surgery above that level. Please see: https://regenexx.com/blog/pain-after-back-fusion-adjacent-segment-disease/ and https://regenexx.com/blog/back-fusion-outcome-fusion-leads-to-dead-multifidus/ https://regenexx.com/blog/multifidus-back-pain/ These are issues not commonly focused on by Orthopedic surgeons, except for suggesting additional surgery, but may be worth a try. For assistance in setting up an exam with a Regenexx Doctor, or to see if you would be a Candidate, please call 855 622 7838.

  6. Emily

    This was such a great article to find. I have a spontaneous spinal CSF leak and hEDS. Shortly after all of my CSF leak symptoms started I was having constant calf muscle tightening and twitching and ended up tearing my gastroc muscle with just a small movement. This connects the dots for me, which is great. I recently had an epidural blood patch to try and treat the leak and during the procedure my calves were both twitching like crazy. Unfortunately, the first patch was unsuccessful, but really interesting to make this connection.


    1. Regenexx Team

      Hi Emily,
      Glad it helped connect the dots! Hoping the next patch is successful. If not let us know…

  7. T

    Chris, I’m hoping this is my problem. My calf began twitching about 3 weeks ago, and at least once or twice a week there is also some mild tingling happening in my shin and sometimes hamstring on same leg. I of course went to google and have convinced myself I have ALS even without other symptoms. It’s literally just this calf twitch that is terrifying me. There is also some twitching that occasionally happens in my eyelid and some other random parts of my body, but the left calf is more or less regular and persistent. No pain, so I didn’t think it was sciatica.

    1. Regenexx Team

      Hi T,
      We’d need to examine you to see what’s going on in your situation. The most likely thing would be an S1 issue in low back, despite no back pain, which we can treat. Please see: https://regenexx.com/conditions-treated/spine/ If you’d like to do that, please either submit the Candidate form here: http://www.regenexx.com, or give us a call at 755 622 7838.

  8. Barb oldenburg

    Please help me. I have been a R.N for many years. I had a severe allergic reaction to a medication. Since that time my lower legs have both been twitching small twitches and when I walk it becomes intense pains. I have had many tests… no answer found. Presently have no life ! My tests included MRI lower spine . Something is being missed Please help !!! barb

    1. Regenexx Team

      Hi Barb,
      Please see: https://regenexx.com/blog/antibiotic-tendonitis-can-ruin-a-life/ We’d need more information through a Candidacy review to see if we can help in your case. To do that please give us a call at 303 429 6448, or submit the Candidate form here: centenoschultz.com

  9. Terri

    I’ve had constant twitching in both calves for 14 months and they get so tight and sore after exercise. The whole thing started when I started getting a buzzing in my right calf and a physio fixed it by treating my lower back. But now it’s a constant battle. MRI came up clean for that area though – could it still be lower back but not show anything on an MRI? Sometimes my lower back is sore to touch.

    1. Regenexx Team

      Hi Terri,
      Yes, it can. Treatment decisions should not be made on imaging like MRI alone. A thorough exam is needed. Please see: https://regenexx.com/blog/hip-labral-tear-recovery-without-surgery/

  10. Mark

    What kind of doctor do I see to look into this? I have constant very subtle, almost bubbly feeling in both calves.

    1. Regenexx Team

      Hi Mark,
      Here are locations where the type of exam needed can be done: https://regenexx.com/clinics/

  11. Bostongirl

    Hi. I’m 40 year old female. I’ve had a twitch in my right calf for almost a week. Starting yesterday I have a buzzing or tingling sensation behind my right knee on and off. It’s not painful at all but very annoying. Not sure if this is related but 2 months ago i had a cyst removed from my brain tangled in my cranial nerves. More recently, i fell down a few stairs but landed on my left side. Not sure when or if I need to see a doctor.

    1. Regenexx Team

      Hi Bostongirl,
      You need to see a Doctor. There are 2 in the general area. Let us know if you want help in setting up an exam.

  12. Susan Williams

    Interesting article. I’ve had this problem for many years; sometimes worse than others. Makes my leg ache too. I fractured a lower lumbar vertebra. Think I will now pursue a remedy. Have sought GP’s advice in the past and – no surprise here – was informed nothing to do with my back. I also have a bunion on that left foot, not the right. Hope my chronic pain doesn’t lead to early death!!

  13. Mark C

    I was helping my mother move light furniture on Saturday. On Sunday, my lower back was sore and my calf muscle would twitch/pulsate throughout the day. I lose my insurance on the first of the month until October 1 because I am switching jobs. Is that considered long-term damage in the event that there was an issue as mentioned in your article? Also, could the calf muscle the pulsating due to a muscle sprain or strain in the back?

    1. Regenexx Team

      Hi Mark,
      That’s an unfortunate timing issue, but we’d need to examine you to see what’s going on in your case to answer your question. Depending on what’s going on, it may resolve, or continue. If you want it looked into, there is a Regenexx location in the Dallas area: https://regenorthosport.com/?utm_source=regenexxreferral&utm_campaign=regenorthosport

  14. Jerica

    I have a bulging disk in my L5-S1 which was diagnosed in March by MRI. I have been getting back injections on and off for pain. In late sept my calf muscles randomly started twitching non stop and haven’t stopped since. What is going on. Muscle relaxants do not help.

    1. Regenexx Team

      Hi Jerica,
      What kind of back injections?

  15. Michael Wright

    Ever since my TLIF lower spine fusion surgery in 2013, both my calves have fast twitched and cramped non stop. I even went to a neurologist because I thought it could be ALS. Relieved the testing was negative. But it’s so annoying and can def make your legs ache. My foot will even jump sometimes they twitch so hard. Twitching all the way from my lower hamstring, back of knee and down to my Achilles tendon.

    1. Chris Centeno, MD Post author

      That would most likely indicate that the S1 nerve is still being irritated.

  16. Geraldine kroneiss

    I’m having some pain in outer thigh and calf. When I sit the problem starts. I can feel when it’s gonna start. My calf and down my foot. It’s like the muscle stretches and moved by itself. It’s sometimes both legs but right now my left side. I have to get up and walk. It is stopping me from sleeping. It’s horrible. I had surgery on my neck 3 years ago. There’s a cage in there. Still have a lot of pain. Is it due to that? Is it starting again?

    1. Chris Centeno, MD Post author

      It’s possible that this is due to nerve issues in the neck or back.

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