Research

How Does PRP Compare to a DMOAD Drug Candidate?

Disease-modifying osteoarthritis drugs (DMOADs) are one of the holy grails of medicine. The idea is that you can inject something in a knee that will reduce the progression of osteoarthritis and that will, therefore, reduce the need for a knee replacement. I have previously blogged about a company called Biosplice that was testing a DMOAD…read more

Why Counting Platelets in High-Dose PRP Can Be a Fool’s Errand

There’s a huge current trend in more advanced clinics to buy a hemoanalyzer and count the platelet content of the PRP produced by the clinic. While on the surface, this would seem to be a noble effort, the devil is always in the details. Regrettably, the fine print on this one shows that most of…read more

I’m Back, a Bum Knee, Another Paper Accepted for Publication, and TOBI

I’m back from my early summer sailing sabbatical, well-rested, and ready to go. As a result, I have a few topics to cover this Father’s Day. Let’s jump in. On this trip, we made it from the northern west coast of Italy (the Genoa area) to Sardina. Along the way, we went down through Portofino,…read more

The Great California Worker’s Comp PRP Magic Trick

Worker’s comp is one of those insurance company types that, more often than not, has been covering PRP. However, a colleague recently sent a “Guideline” issued by the California workers comp that removes PRP coverage. Today, I want to dive deeply into this document and explain why it’s more of a magic trick than a…read more

What Happens to Umbilical Cord IV Stem Cells in the Lungs? It’s NOT Pretty

One of the most common delivery methods for stem cells is intravenous (IV). However, this seems to have been chosen more because it’s easy for the clinic than because it’s the best way to deliver stem cells. Today, I will discuss a new study and review why IV stem cell infusions remain problematic. In particular,…read more

2024 Update on Interventional Orthobiologics Studies and Product Pipelines

Interventional orthobiologics research continues to advance at a furious pace. Last year, I published a blog that attempted to look ahead a bit at studies and products that may be available and posited a timeline for when that could happen. This year, I went deeper to search product studies/FDA trials and some key research studies…read more

Another New Study Says PRP Dose Is Critical: Why We Have ALWAYS Used High Dose PRP

Physicians who read the orthobiologics literature and follow the latest and greatest have caught onto a message I’ve been delivering for almost two decades. The most critical aspect of PRP is the dose and concentration of platelets delivered to the patient. A new study published last week adds more fuel to that fire. Let’s dig…read more

PRP Concentration vs. Dose: Why Concentration Is as Important as Dose

If you read this blog, you know I often write about what I experience daily. This past weekend an orthopedic surgeon on Linkedin promoted test tube PRP at 3-4X concentration. Like others I have seen, his focus was on the total dose delivered to a knee and not on the concentration. Meaning he posited that…read more