Mesenchymal Stem Cells
Mesenchymal stem cells (or “MSCs”) are multipotent stem cells found in bone marrow that are important for making and repairing skeletal tissues, such as cartilage and bone. Mesenchymal stem cells can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells), and adipocytes (fat cells which give rise to marrow adipose tissue).
Subscribe to the BlogBone Marrow Stem Cell Dose Matters in Knee Osteoarthritis
If there’s one overarching theme in orthobiologics that I have been discussing for almost two decades, it’s that measuring and delivering higher doses are critical for success. Despite this, 99% of physicians who offer these procedures don’t know what dose they’re delivering and use bedside kits that can only achieve low doses. Today we’ll go…read more
CFU-f 101: To Be an Orthobiologics Expert You MUST Learn This
The blind leading the blind is one of my favorite expressions. As one of the founders of this field of interventional orthobiologics, the fact that this statement applies to much of our existing orthobiologics education is concerning to me. Nowhere is this more true than the concept of stem cell dose and CFU-f assays. Hence,…read more
Our Most Recent Publication on Blood Clots, Anticoagulation, and Knee Arthritis BMC Procedures
New medical technology attains a few predictable levels as it’s adopted by more and more physicians. Because we’ve been performing knee bone marrow concentrate procedures for a very long time and collecting registry data on them, we’re well into the final level. As a result, we just published a peer-reviewed research paper on the risk…read more
Can You Easily Determine MSC Content of BMC at the Bedside?
Dose is a key metric in medicine. However, dosing cells isn’t used in most of orthobiologics. However, is that about to change? Will it be possible to get a dose of stem cells at the bedside when using BMC or Mfat? Let’s dig in. Dose Matters Determining the stem cell content of Bone Marrow Concentrate…read more
Umbilical Cord MSCs Sales 2.0: Using the Expanded Access Program?
You have read here many times about the fraudulent claims of umbilical cord tissue vendors that they are selling products with millions of young and vital mesenchymal stem cells. That was followed by the FDA crackdown last year and all seemed quiet for a while. However, now we’re seeing a new business plan emerge that…read more
Regenexx Snags Another Patent
Regenexx has been granted dozens of patents throughout the years. This week we received a Korean patent on devices that create platelet lysate for clinical use. Let’s dig in. What is Platelet Lysate (PL)? Platelet lysate is a key technology that Regenexx developed for clinical use way back in 2005. Platelets have growth factors and…read more
Tony Robbins Life Force Review
I’ve been getting lots of emails lately about the Tony Robbins book “Life Force”. It’s always interesting as a physician to get bombarded by patients with what sounds like misinformation, but since you haven’t looked at the source, you’re not sure how to respond. In fact, patients come in with new things every day, so…read more
Mesenchymal Stem Cell Research Continues To Increase
Short blog this morning. I’ve posted many times about how the year-over-year research on mesenchymal stem cells (MSCs) continues to increase. At some point, I expected this to level off, but that hasn’t happened yet. Let’s dig in. What is a Mesenchymal Stem Cell? If you’ve had a bone marrow concentrate procedure, this is believed…read more
