Published Peer-Reviewed Research

Procedures using Regenexx injectates have been studied extensively for almost 20 years and Regenexx provider patients are part of the world’s largest human mesenchymal stem cell re-implantation registry for orthopedic purposes.

Latest Published Research

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Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics

Nature, 2025

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Intradiscal Injections of Bone Marrow Concentrate or Leukocyte-Rich Platelet-Rich Plasma for the Treatment of Cervical Discogenic Pain: A Case Series

Cureus, 2025

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Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up

BMC Musculoskelet Disord, 2024

Regenexx Published Research Archive

• Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics
  Nature, 2025
• Intradiscal Injections of Bone Marrow Concentrate or Leukocyte-Rich Platelet-Rich Plasma for the Treatment of Cervical Discogenic Pain: A Case Series
  Cureus, 2025
• Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up
  BMC Musculoskelet Disord, 2024
• Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group
  Dovepress, 2024
• Percutaneous autologous bone marrow concentrate for knee osteoarthritis: patient-reported outcomes and progenitor cell content
  International Orthopaedics, 2022
• The rate of venous thromboembolism after knee bone marrow concentrate procedures: should we anticoagulate?
  International Orthopaedics, 2022
• Image-Guided Injection of Anterior Cruciate Ligament Tears With Autologous Bone Marrow Concentrate and Platelets: Midterm Analysis From a Randomized Controlled Trial
  Biologic Orthopedic Journal, 2022
• The Treatment of Bone Marrow Lesions Associated with Advanced Knee Osteoarthritis: Comparing Intraosseous and Intraarticular Injections with Bone Marrow Concentrate and Platelet Products
  Pain Physician, 2021
• Regarding “Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials”
  The Journal of Arthroscopy and Related Surgery, 2021
• Use of Bone Marrow Concentrate to Treat Pain and Musculoskeletal Disorders: An Academic Delphi Investigation
  Pain Physician, 2021
• Colony Forming Potential and Protein Composition of Commercial Umbilical Cord Allograft Products in Comparison With Autologous Orthobiologics
  The American Journal of Sports Medicine, 2021
• Regenerative Injection Treatments Utilizing Platelet Products and Prolotherapy for Cervical Spine Pain: A Functional Spinal Unit Approach
  Cureus, 2021
• Cryopreserved bone marrow aspirate concentrate as a cell source for the colony-forming unit fibroblast assay
  Cytotherapy, 2020
• Past, Current and Future Interventional Orthobiologics Techniques and How They Relate to Regenerative Rehabilitation: A Clinical Commentary
  The International Journal of Sports Physical Therapy, 2020
• A Randomized Controlled Trial of the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate and Platelet Products Compared to Exercise Therapy: A Midterm Analysis
  Stem Cells International, 2020
• Bone Marrow Concentrate (BMC) Therapy in Musculoskeletal Disorders: Evidence-Based Policy Position Statement of American Society of Interventional Pain Physicians (ASIPP)
  Pain Physician Journal, 2020
• Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration.
  Journal of Translational Medicine, 2019
• Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentrationdependent manner
  Bone & Joint Research, 2019
• Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft.
  BioMed Research International, 2019
• Symptomatic anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow concentrate and platelet products: a non-controlled registry study.
  Journal of Translational Medicine, 2018
• A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis; a randomized control trial with 2 year follow-up.
  Journal of Translational Medicine, 2018
• A New Atlanto-Occipital (C0-C1) Joint Injection Technique
  Pain Medicine, 2017
• Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy.
  Journal of Translational Medicine, 2017
• The use of lumbar epidural injection of platelet lysate for treatment of radicular pain.
  Journal of Experimental Orthopaedics, 2017
• Interventional Orthopedics in Pain Medicine Practice
  Techniques in Regional Anesthesia and Pain Management, 2016
• A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.
  International Orthopaedics, 2016
• Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study.
  Journal of Translational Medicine, 2016
• Performing a Better Bone Marrow Aspiration.
  Physical Medicine and Rehabilitation Clinics of North America, 2016
• A Dose Response Analysis of a Specific Bone Marrow Concentrate Treatment Protocol for Knee Osteoarthritis.
  BMC Musculoskeletal Disorders, 2015
• Anterior Cruciate Ligament (ACL) Tears treated with Percutaneous Injection of Autologous Bone Marrow Nucleated Cells: A Case Series.
  Journal of Pain Research, 2015
• A Prospective Multi-site Registry Study of a Specific Protocol of Autologous Bone Marrow Concentrate for the Treatment of Shoulder Rotator Cuff Tears and Osteoarthritis.
  Journal of Pain Research, 2015
• Amide-Type Local Anesthetics and Human Mesenchymal Stem Cells: Clinical Implications for Stem Cell Therapy.
  Stem Cells Transl Med, 2014
• Clinical challenges and opportunities of mesenchymal stem cells in musculoskeletal medicine.
  PM R, 2014
• Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritis of the Hip; Treatment Registry Results for 196 Patients.
  Stem Cell Research and Therapy, 2014
• Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft
  BioMed Research International, 2014
• Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group.
  Wien Med Wochenschr, 2013
• A Case Series of Percutaneous Treatment of Non-Union Fractures with Autologous, Culture Expanded, Bone Marrow Derived, Mesenchymal Stem Cells and Platelet Lysate
  Journal of Bioengineering and Biomedical Science, 2011
• Safety and Complications Reporting Update on the Re-implantation of Culture-Expanded Mesenchymal Stem Cells using Autologous Platelet Lysate Technique.
  Curr Stem Cell Res Ther, 2011
• Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone.
  J Orthop Res, 2010
• Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique.
  Curr Stem Cell Res Ther, 2010
• Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
  Regenerative Sciences Inc, 2008
• Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells.
  Med Hypotheses, 2008
• Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: A case study.
  Pain Physician, 2006