2021 Bone Marrow Research Infographic

Every year, I spend a number of hours searching the published medical literature for various new publications in orthobiologics and cell therapy. I produce two infographics, one focused on bone marrow cells and the other on all cell types. This is the 2021 edition of the bone marrow infographic.

(Click here to view larger)

What Is This?

This is the result of dozens of hours of searching the US Library of Medicine for publications on bone marrow stem cells used to treat orthopedic applications. Each circle represents a research study on the outcome of the therapy with a link to that paper. The author, location treated (or the clinical application), the number of patients treated, and the type of cells used are listed. Finally, the scalpel icon represents a surgical study and the syringe icon an injection study.

To see the final PDF, just click on the image above. That document has active hyperlinks at each circle to each study.

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Why Do This?

I do this both as a way to get myself acquainted with the new literature and as a service for the field. It’s a labor of love and my eyes get a bit crossed each time I do it, so if you find an error or a paper I missed, please don’t hesitate to email me at [email protected].

The History

I do this every year but skipped 2020 due to COVID. If you search the blog under “bone marrow infographic”, prior years will come up.

Using this Document

If you want to use this document for a lecture or to share, just give me a heads up and credit.

What Are the Trends?

Phillippe Hernigou (an orthopedic surgeon from Paris) continues to be a bone marrow stem cell publishing machine. I spoke to him several years ago and he said that he had a slew of other papers ready that he needed to get approved by the government before publishing, so he wasn’t kidding. In addition, I’ve noted much more publishing in the orthopedic surgery space in hip and foot/ankle. Also, there is a steady rise in RCTs being published.

There are also many more publications coming out in various cell types, so I look forward to reviewing those once I put out my all cell types infographic. That should come out within the next week or so, once I recover from updating this behemoth.

The upshot? The research on bone marrow stem cell use in orthopedics continues to get better and better. There are now many more than 13,000 patients who have received this therapy and had their results published and indexed in the US Library of Medicine. That goes all the way back to the 90s, so this is not a new thing anymore, it’s slowly weaving its way into the medical standard of care.

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications. View Profile