Ankle Stem Cell Injections: How Do Same Day vs. Cultured Stack Up?

By /

ankle stem cell injections

Yesterday I compared how same day stem cells used for hand arthritis compared to cultured cells as a hand arthritis surgery alternative – the differences seemed stark for patients with severe thumb arthritis. How do ankle stem cell injections with a same day stem cell procedure (Regenexx-SD) compare to cultured cells?

For this infographic  I took patients from our advanced treatment registry who had been categorized as ankle/foot. The vast majority of these patients in both analyses have large ankle joint arthritis (Tibio-talar), with a few patients having either sub-talar or small foot joint arthritis. For the same day data set, patients with avascular necrosis or loose bodies in the joint were not included; for the cultured procedure all patients were included. As you can see from the graph above, there does appear to be a difference between these two procedures with the cultured procedure providing a better overall result, but, the differences aren’t as stark as for hand arthritis. This difference is more in line with what we see with knee arthritis. In addition, recognize that unlike our knee arthritis data, these data sets are smaller, so as more data is collected and reported these differences could grow smaller, stay the same, or grow larger.

The upshot?  So far, cultured stem cells do appear to have an edge over same day treatments for ankle arthritis, but the differences don’t seem to be as stark as they were for hand arthritis. As always, click on the thumbnail above to see the more detailed PDF.

The Regenexx-SD procedure is used in the U.S. (same day), while the cultured stem cell procedure (Regenexx-C) is not U.S. FDA approved and is only used via license to companies that operate outside of the U.S. for use wholly in a country that allows such use.

Learn about Regenexx procedures for foot & ankle conditions.
Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications. View Profile

If you have questions or comments about this blog post, please email us at [email protected]

NOTE: This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

Get Blog Updates by Email

By submitting the form, you are agreeing that you read and consent to our Privacy Policy. We may also contact you via email, phone, and other electronic means to communicate information about our products and services. We do not sell, or share your information to third party vendors.

Copyright © Regenexx 2021. All rights reserved.



9035 Wadsworth Pkwy #1000
Westminster, CO 80021


*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.