Can the NAD Supplement Help Your Old Stem Cells Act Younger?

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NAD+ has been getting a lot of press lately as a supplement that may help regenerate ageing and fatigued cells. Now, over the past few months, there has been a ton of basic science research on the NAD supplement and how it might actually help stem cells act younger. So today, I’m going to review one of these studies, this one from June of 2016 in Cell Research.

 First, let’s review what NAD+ is and what it does.

What Is NAD+ and What Does It Do?

All of our cells contain a coenzyme called nicotinamide adenine dinucleotide (NAD). NAD+ is the oxidized form of NAD. Our natural NAD+ within our cells keeps our mitochondria healthy and keeps us youthful and energetic. Unfortunately, there is a reduction in NAD+ levels as we age. So are NAD supplements, (NAD+) promising cell regeneration and mitochondrial health, the answer to slowing the aging process and reclaiming our youth and energy? And how does it impact our stem cells, the repairmen in our body?

All of your cells have mitochondria, which act like little batteries, powering each cell. Just like with any battery, however, our mitochondria become less active or burn out as we age. This process also happens in our stem cells, and it’s believed to be one of the major driving factors behind why our stem cells slow down as we age and may not function or repair as well.

I can best explain how this mitochondrial burnout happens as we age through the analogy of a pile of unfolded laundry. The proteins (e.g., carbonic anhydrase) inside of these mitochondrial batteries get “unfolded” over time, just like the unfolded shirts in a big pile of laundry. Proteins that are unfolded don’t work optimally, and as we get older, we get more and more unfolded proteins in the mitochondrial batteries that power our cells.

So how do those proteins get folded in the first place? There is actually a machine, a mechanism, inside your cells called an unfolded protein response (UPR) that folds proteins like a dry cleaner’s machine folds shirts. Think of NAD+ as the electricity that runs the UPR machine—it’s how the whole thing gets its power. As we get older, the electricity to the UPR machine lessens, so we have more unfolded proteins added to our laundry pile. So could supplementing NAD+ turn the power back on for the UPR machine?

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The Study on NAD+ and Stem Cells

In a recent study, researchers “have shown that activation of the mitochondrial unfolded protein response…through administration with an NAD+-raising compound, can rejuvenate stem cells and extend lifespan in mice.” In other words, the researchers found that by supplementing with NAD+, they were able to turn the power back on to the UPR machine in the stem cells of older animals. This resulted in more folded proteins which in turn seemed to make the stem cells work better. So with an NAD+ supplement, the stem cells of older animals actually do act younger!

The upshot? This study was on the stem cells of mice, and it remains to be seen if NAD+ is that effective with older human stem cells; however, with our advanced lab capabilities, we do plan to test this for ourselves to see if an NAD supplement might be helpful for our patients.

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23 thoughts on “Can the NAD Supplement Help Your Old Stem Cells Act Younger?

  1. Lynne Morrison

    Eager to learn results of your testing. Thank you. Lynne

  2. Eric

    Dr. Centeno,

    I’m a patient of Dr. Williams and had a PRP procedure done on my neck, ankle, shoulder and lumbar area 2 weeks ago.

    Is there a quality NAD+ supplement on the market for consumers? Not a NAD+ precursor but NAD+ (the oxidized form of NAD) that is stabilized.

    1. Regenexx Team Post author


      It would appear that the commercially available products in the news do not contain NAD+, but rather nicotinamide riboside and some in combination with pterostilbene which they say boost your body’s NAD+ levels.

  3. Holly Agnor PA-C

    What’s your timeline for starting this testing in lab and what length of study will you do?

    1. Regenexx Team Post author

      Don’t have that information as of yet…stay tuned

  4. Dane

    I bought this supplement in anticipation of my bone marrow aspiration in March. I’ll be taking it daily.

    1. Regenexx Team Post author


      We won’t know if it will help our patients until we complete our testing.

      1. Dane

        Thanks, I understand that, just hedging my bets and looking forward to the future studies. I am taking the Regenexx Stem Cell Supplement, which I know you have data for.

  5. kim

    Am currently working the eval to see if I’m a stem cell candidate. Would be HUGELY interested in knowing if this would be worth taking!

    1. Regenexx Team Post author

      The study in the Blog was a Mouse study. As Dr. Centeno said in the blog, we don’t know what effect it has on human stem cells so we are testing it in our lab to see if it would be helpful for our paitents. Till then we don’t know.

  6. Rhonda Duffy

    I was so excited till I got to the end and saw the testing had been just on mice. If it does prove to work on people, I’ll be the first in line for it.

  7. annette phillips

    I would definitely be interested in knowing the results of your testing re the NAD+ !!!!!Thanks

  8. Jane

    Please hurry with that, lol!
    Afraid thst at 65, my batteries are about depleted.

  9. Maxey Wirt T.

    What is the current status of your NAD+ Testing?

    1. Regenexx Team Post author

      It’s on the list but things of higher priority have been addressed first.

  10. Dave

    Any news on your NAD+ testing? It’s now been over a year since the animal study showed increasing NAD+ rejuvenates aged stem cells. As an aged stem cell owner it would be great to know! Thanks

    1. Regenexx Team Post author

      Not yet! We will post the results when we have them, but we have’t gotten to it yet, as our research team has had higher priority projjects on the docket.

  11. LC

    Please post your results on NAD+ when you get them! It would be great to have some additional independent (from the Elysium folks) data on humans, given of course, the constant problems with generalizing to humans the results from animal models – the mice are not furry little humans problem. Questions I personally have are: is NAD+ an electron provider to the ETC and does dietary NAD+ get there; and, is NAD+ an autophagy mimicker.

    1. Regenexx Team Post author

      We will definitely post results when we have them, there have simply been higher priority issues for our research team.

  12. Dave

    As you know many of us are waiting for your Nad+ testing. Any update yet?

    1. Regenexx Team Post author


      Promise you’ll be the first person notified!

  13. Jg

    Dr Centeno,
    Any updates on NAD+? Assuming the study never happened, any potential downside of including a precursor (NMN or NR) of this supplement in your regimen? Reading through some of the info out there, Dr Sinclair -the lead research scientist from Harvard who’s looking into NAD+, takes NMN regularly

    1. Chris Centeno, MD Post author

      Certainly not a bad supplement to try.

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