Continuing to Advance Orthopedic Regen Med: MSC Enhanced SCP

by Chris Centeno, MD /

stem cell prp

We have pioneered orthopedic regenerative medicine since 2005. Since that time we were the first in the U.S. to use advanced, culture expanded mesenchymal stem cells for orthopedic injuries and the first to use same day stem cells for that same purpose. We’ve made many advancements since then, but one of the newest is MSC enhanced SCP.

What is an MSC?

MSC stands for mesenchymal stem cell. There are two procedures that we use that have MSCs. The same day procedure in the U.S. has been evolved to maximize the number of MSCs and other stem cells (Regenexx-SD). The procedure we use in our licensed Grand Cayman site is different, in that MSCs are isolated from the bone marrow and then grown in culture to bigger numbers (Regenexx-C).

Different Cell Requirements

With the Cayman cultured procedure, we often flood arthritic joints with high cell numbers to help the joint. However, we’ve noticed through the years two important concepts that are at the heart of MSC enhanced PRP. Platelet rich plasma (PRP) is pretty good at helping tendons and ligaments heal, as long as there are lots of cells already living in those tissues. The PRP works by acting as an “Espresso Shot” for the local tendon and ligament stem cells, causing them to work harder and faster in trying to repair tissue damage. Our in-vitro data has also shown that older MSCs have a direct dose-response relationship to PRP concentration, which is what birthed our SCP (Super Concentrated Platelets). MSCs are also great at repairing ligaments and tendons, as they have a natural fibroblastic morphology. Combining these technologies where high concentrations of PRP (what we call SCP) are enhanced by small numbers of MSCs, allows us to treat the panoply of tendon/ligament issues that usually plague our patients with arthritis.

Introducing “MSC Enhanced SCP”

My use of MSC enhanced PRP began last year when I was treating a patient down at our advanced Grand Cayman site. The patient had a list of joints that needed to be treated as well as numerous tendons and ligaments. He had grown a good number of cells, but even his stout yield would never cover all of the 10-15 areas that needed treatment. As a result, I did what all good doctors do, I innovated. Based on 11 years of experience in using same day and cultured stem cells, I knew that the MSC requirements for treating tendons and ligaments were likely far less than for a joint. As a result, I knew I could ask our staff to take more blood to mix up large volumes of SCP and that I could enhance that SCP with lower amounts of MSCs and likely end up with a regenerative cocktail that was the equivalent of a same day stem cell procedure. When the patient reported exceptional results, I tried this on a few more patients and when those patients began reporting game changing outcomes, I knew my educated guess was likely correct. MSC enhanced PRP was born!

The upshot? MSC enhanced PRP has now become a big staple of what we do at the Grand Cayman clinic. It works best in those patients who have many different issues. For example, a patient who has knee arthritis and many irritated tendons around the knee and who also has a neck ligament issue and tennis elbow. Or the older and highly active guy or gal who has a number of different beat up areas that need to be treated. Given that this is many of the patients we see down in Grand Cayman, it’s a great fit. We’ll keep on advancing our technology, which is how we roll at Regenexx!

The Regenexx-C procedure is not approved by the US FDA and is only offered in countries via license where culture expanded autologous cells are permitted via local regulations. 

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15 thoughts on “Continuing to Advance Orthopedic Regen Med: MSC Enhanced SCP

  1. Judith

    This sounds interesting as I’ve already had stem cell surgery but tendons seem to hurt. General walking is not bad however tibia and surrounding areas hurt when on feet to long or walking to much. What is the price of this and I assume you have to fly to the Caymans to get. When will it be available in the states?

    1. Regenexx Team

      Judith,
      This won’t be available in the United States for some time. Yes, this therapy is down in Grand Cayman. We generally try to avoid surgery with stem cells instead focus on Advanced Precision injection with stem cells. In addition, most surgeons are using much less Advanced Cell Therapy then Regenexx offers even in the United States.

  2. deb

    Do Regenexx providers have a set fee for PRP treatments for osteoarthritis of the knee? if so, how much is 1 treatment?

    1. Regenexx Team

      Deb,
      Procedures are based on exam and customized for each patient, so general price quotes can’t be given. If you’d like to see what would likely be needed in your situation, please fill out the Regenexx candidate form: http://www.regenexx.com/the-regenexx-procedures/knee-surgery-alternative/

  3. María MUSSENDEN

    How is this working with hip ostheoarthritis?

  4. María MUSSENDEN

    When multiple body sites are involved, how does this work? Does one injection address all the problems, or each site receives an individual injection? I guess also, each site that has a different pathology might have different requirements/needed formula for the injection received? Is that the case?

    1. Regenexx Team

      Maria,
      Each site is individually injected, and yes, each site receives an injection customized for that specific situation. Regenexx-C (the cultured procedure) works particularly well for severe Hip Osteoarthritis. Less severe cases can be treated with Regenexx-SD, the same day stem cell procedure done in the US which is also customized to the situation: https://regenexx.com/blog/advanced-customized-orthobiologics/

  5. Masuma Downie

    If I read the above explanation correctly, are the Regenexx-C and the SCP procedures somewhat more customized to each individual case? Perhaps due to the time factor? Unlike the SD procedure which is same day ?Thanks.

    1. Regenexx Team

      Masuma,
      The additional stem cells available to work with once they are grown in culture do give us many more to work with. While the specific Regenexx-SCP plus Regenexx-C procedure is only done down in Grand Cayman, all Regenexx procedures are customized: https://regenexx.com/blog/advanced-customized-orthobiologics/

  6. Karl Steere

    I have had prp this past week. I was amazed that I had very little bruising. I have watched the Videos from major hospital sites that are attempting to do stem cells. The difference I noticed right away was a mallet and a large needle that they used together. I remember reading from one of your blog’s that this doesn’t result in the optimum number of stem cells being extracted and reinjected. Your technique is different from this and results in a higher number of viable stem cells if I understood correctly. Anyway I have another treatment in the future and I hope it is just as successful. It is too early to tell, but I believe the outcome is going to help my arthritic hip.

    1. Regenexx Team

      Karl,
      Though anti-intuitive for some, the issue is that Regenerative Interventional Orthopedics is a completely different specialty built on a completely different paradigm, and what tends to happen in these situations is that stem cells and prp simply become added on “treatment options” without adequate training, knowledge and experience. http://www.regenexx.com/how-not-to-draw-stem-cells/

  7. David Davenport

    “… to treat the panoply of tendon/ligament issues that usually plague our patients with arthritis.”

    Dr. Centeno, you ought to say more and expand upon tendon/ligament issues associated with arthritis.

    I wish you’d talk more about the lax ligaments –> joint instability –> osteoarthritis cascade.

    Other orthopedic physicians, even some doing regenerative injections, assume that arthritic complaints are entirely a matter of arthritis within a joint. They shrug off the possibility that ligament and tendon problems might be the distal cause of OA,

    I wish you’d talk more about the lax ligaments –> joint instability –> osteoarthritis cascade.

    1. Regenexx Team

      David,
      Unfortunately the field of orthopedics has a compartmentalized view of the human body, which is why it makes sense in that paradigm to simply remove something without understanding how that impacts everything else. Joint Instability and Lax ligaments has been one of the main focuses of the blog over time and there are countless blogs written on how joint instability causes everything from bone spurs, to OA to problems in places other than the location of the instability, which is why we always check for underlying instability issues. On the website, http://www.regenexx.com, go to the Blog section and in the search box, put “joint instability”, also go to the Vertical Category listings and go to “Tendons and Ligaments”, ACL, Lumbar, Hip, etc. There are just too many to list here!

  8. John Corpening

    Would your stem cell treatment benefit someone with bone on bone arthritis in the shoulder?

    1. Regenexx Team

      John,
      Yes, we treat bone on bone arthritis of the shoulder regularly, as our research has shown that severity of arthritis does not affect outcome. The shoulder has the greatest range of motion of joints in the body made possible by a large network of tendons and ligaments, and therefore is very susceptible to instability, which often leads to arthritis:http://www.regenexx.com/blog/shoulder-instability-recovery-time/ http://www.regenexx.com/the-regenexx-procedures/shoulder-surgery-alternative/

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
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