Does Knee Arthritis Severity Impact Stem Cell Treatment Outcome?

By Chris Centeno, MD /

Receive a Regenexx® Patient Info Packet by email and learn why it's a superior regenerative solution.

bone on bone knee and stem cells

For so many therapies used to treat knee arthritis, the best way to determine if a specific therapy will help is the severity of the disease. Meaning that less severe knee arthritis responds better than the more severe forms of the disease. However, one of the things we’ve observed about our same day bone marrow based stem cell therapy is that this rule goes out the window. This morning we’ll review this by going over some data from our research meeting yesterday.

Knee OA Severity and Other Treatments

Pretty much every treatment for knee OA (osteoarthritis) follows the rule that if the arthritis is more severe, the treatment will be less effective or last less time. This is true for steroid shots and hyaluronic acid gel injections. Surgeries like microfracture or other cartilage repair technologies generally follow this same rule. Even PRP is the same, as while it can last a year or two in mild arthritis knees, it only lasts weeks to months when used in a patient with severe arthritis.

Our Past Findings on Severity and the Regenexx-SD Procedure

We’ve been studying the Regenexx-SD (same day bone marrow based stem cell procedure) for 14 years. Way back when, as we got enough registry data, it became clear that patients who had the procedure with severe knee arthritis were doing as well as those with mild arthritis. We published on this phenomenon in a large case series and eventually published a randomized controlled trial on the knee OA procedure. 

On the other hand, if you have more severe hip arthritis, that does impact the outcome of the Regenexx-SD procedure. In those cases, the improvement declines with increased severity. That’s consistent not only in our data but also in that reported by others.

A Nice Image from Our Science Meeting

At Regenexx, I constantly meet with our science team to go everything from new research to be published to existing clinical or lab studies, to process improvement on existing procedures. Every two weeks we have a science team meeting with the whole group where everyone presents the results of what they’re working on. In yesterday’s meeting, our CSO Neven Steinmetz, Ph.D. put up this slide:

This was actually an audit on one of the many clinical trials we’re involved in that thankfully demonstrated that very few mild knee arthritis patients were entering into this observational research. The study looks at the chemical makeup of the synovial fluid in moderate to severe knee OA patients, so only having 3-5% mild knee OA patients in that study is a good thing. However, what was interesting is that in this 170 patients who had knee MRIs read by our physicians and the results recorded, between 76-81% (depending on which OA grading scale you use) were moderate to severe knee arthritis patients. Despite being knee replacement candidates, these patients still did very well with the procedure. For example, 70% report more than 50% improvement at 6 months and a year out from the procedure. This is consistent with the data we have collected that shows that the severity of knee OA just doesn’t matter when it comes to our Regenexx-SD procedure.

The upshot? At Regenexx, we have a huge commitment to ongoing research. In this case, we have looked at the issue of knee arthritis severity and whether this makes someone a poor candidate for the procedures we offer. For PRP that does matter as it does for hips even when we use the bone marrow therapy, but for the same day stem cell procedure, our data continues to demonstrate that it doesn’t matter. That’s a good thing if you happen to have severe knee arthritis!

Category: Uncategorized

Leave a Reply

Your email address will not be published. Required fields are marked *

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
View Profile

Get Blog Updates by Email

Get fresh updates and insights from Regenexx delivered straight to your inbox.

Regenerative procedures are commonly used to treat musculoskelatal trauma, overuse injuries, and degenerative issues, including failed surgeries.
Select Your Problem Area
Shoulder

Shoulder

Many Shoulder and Rotator Cuff injuries are good candidates for regenerative treatments. Before considering shoulder arthroscopy or shoulder replacement, consider an evaluation of your condition with a regenerative treatment specialist.

  • Rotator Cuff Tears and Tendinitis
  • Shoulder Instability
  • SLAP Tear / Labral Tears
  • Shoulder Arthritis
  • Other Degenerative Conditions & Overuse Injuries
Learn More
Cervical Spine

Spine

Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Knee

Knees

Knees are the target of many common sports injuries. Sadly, they are also the target of a number of surgeries that research has frequently shown to be ineffective or minimally effective. Knee arthritis can also be a common cause for aging athletes to abandon the sports and activities they love. Regenerative procedures can be used to treat a wide range of knee injuries and conditions. They can even be used to reduce pain and delay knee replacement for more severe arthritis.

  • Knee Meniscus Tears
  • Knee ACL Tears
  • Knee Instability
  • Knee Osteoarthritis
  • Other Knee Ligaments / Tendons & Overuse Injuries
  • And more
Learn More
Lower Spine

Spine

Many spine injuries and degenerative conditions are good candidates for regenerative treatments and there are a number of studies showing promising results in treating a wide range of spine problems. Spine surgery should be a last resort for anyone, due to the cascade of negative effects it can have on the areas surrounding the surgery. And epidural steroid injections are problematic due to their long-term negative impact on bone density.

  • Herniated, Bulging, Protruding Discs
  • Degenerative Disc Disease
  • SI Joint Syndrome
  • Sciatica
  • Pinched Nerves and General Back Pain
  • And more
Learn More
Hand & Wrist

Hand & Wrist

Hand and wrist injuries and arthritis, carpal tunnel syndrome, and conditions relating to overuse of the thumb, are good candidates for regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Hand and Wrist Arthritis
  • Carpal Tunnel Syndrome
  • Trigger Finger
  • Thumb Arthritis (Basal Joint, CMC, Gamer’s Thumb, Texting Thumb)
  • Other conditions that cause pain
Learn More
Elbow

Elbow

Most injuries of the elbow’s tendons and ligaments, as well as arthritis, can be treated non-surgically with regenerative procedures.

  • Golfer’s elbow & Tennis elbow
  • Arthritis
  • Ulnar collateral ligament wear (common in baseball pitchers)
  • And more
Learn More
Hip

Hip

Hip injuries and degenerative conditions become more common with age. Do to the nature of the joint, it’s not quite as easy to injure as a knee, but it can take a beating and pain often develops over time. Whether a hip condition is acute or degenerative, regenerative procedures can help reduce pain and may help heal injured tissue, without the complications of invasive surgical hip procedures.

  • Labral Tear
  • Hip Arthritis
  • Hip Bursitis
  • Hip Sprain, Tendonitis or Inflammation
  • Hip Instability
Learn More
Foot & Ankle

Foot & Ankle

Foot and ankle injuries are common in athletes. These injuries can often benefit from non-surgical regenerative treatments. Before considering surgery, consider an evaluation of your condition with a regenerative treatment specialist.
  • Ankle Arthritis
  • Plantar fasciitis
  • Ligament sprains or tears
  • Other conditions that cause pain
Learn More

Is Regenexx Right For You?

Request a free Regenexx Info Packet

REGENEXX WEBINARS

Learn about the #1 Stem Cell & Platelet Procedures for treating arthritis, common joint injuries & spine pain.

Join a Webinar

RECEIVE BLOG ARTICLES BY EMAIL

Get fresh updates and insights from Regenexx delivered straight to your inbox.

Subscribe to the Blog

FOLLOW US

Copyright © Regenexx 2019. All rights reserved. | Privacy Policy

*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.

LinkedIn
Email