PRP in Micro Fracture: Does PRP make better Cartilage in Patients over 40?

By /

 prp in micro fracture

Does putting PRP in Micro Fracture make better cartilage in patients over 40?  Micro fracture is a surgical procedure whereby a hole in the cartilage is treated by poking holes in the bone. The idea is that the bone marrow from the inside of the bone (with stem cells) will leak into the cartilage hole and help it heal with a scar type of cartilage, providing some cushioning for the area. One of the problems with knee micro fracture is that it tends to work best in young athletes and the results fall off precipitously in patients over 40 years old. As a result, some smart surgeons asked themselves if they added platelet rich plasma (concentrated blood platelets that have all sorts of good healing growth factors) would it make micro fracture cartilage any better in older patients? They looked at 49 patients who underwent arthroscopic microfracture for a cartilage lesion (less than 4 cm(2)) with early arthritis  aged 40-50 years, were randomly divided into 2 groups: a control group with only arthroscopic microfracture (25 patients) and a study group with arthroscopic microfracture and PRP (24 patients). They performed second look arthroscopies in 10 patients of each group to identify the extent of cartilage restoration at 4-6 months after the surgery. There were significant improvements in clinical results between preoperative evaluation and postoperative at 2 years post surgery in both groups (p = 0.017). Clinical results were significantly better in the study PRP group than in the control group (p = 0.012). In the 2nd look arthroscopies, there was better hardness and elasticity of the repair cartilage in the PRP patients. The upshot? If I was getting micro fracture surgery and was over 40 (which I am), I’d ask the surgeon to throw in some PRP!

Learn about Regenexx procedures for knee conditions.
Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications. View Profile

If you have questions or comments about this blog post, please email us at [email protected]

NOTE: This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

Get Blog Updates by Email

We do not sell, or share your information to third party vendors.

By submitting the form you agree that you’ve read and consent to our Privacy Policy. We may use email, phone, or other electronic means to communicate information about Regenexx.

We will provide information to help you decide whether you want to schedule an evaluation with a Regenexx Physician.

Insurance typically covers evaluations and diagnostic testing (if recommended). Most insurance plans currently do not cover Regenexx Procedures.

Copyright © Regenexx 2021. All rights reserved.



9035 Wadsworth Pkwy #1000
Westminster, CO 80021


*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.