Our Latest Research Paper on Disc Stem Cell Injections

By Chris Centeno, MD /

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disc stem cell injection

Way back when in 2005, I performed what I believe was the first disc stem cell injection on earth. While this procedure has since become more commonplace, when we did this back then, it was “out there.” Today we have published a case series using a novel technique that was developed through years of refinement. This procedure is currently the subject of an FDA-approved phase-2 trial and is also used at our licensed Grand Cayman site.

What Do Disc Stem Cell Injections Help the Most?

While it’s easy to believe that disc stem cell injections are magic, that’s really not accurate. When a technology is new to physicians, they tend to ascribe magical thinking to what it’s capable of accomplishing. That’s where we are right now, with many clinics promising to regrow new discs. However, after 12 years of injecting discs, we learned what’s really possible. To find out more see my video below:

What Does This Stem Cell Procedure Help?

This procedure uses some very special technology that made it the subject of an FDA trial. In this case, we figured out that using stem cells that were conditioned to survive the disc was best. Why? The injured or degenerated disc is a hostile environment where cells can’t thrive, which is one of the reasons degenerative discs degenerate over time.

This procedure doesn’t regenerate a new disc from a degenerated disc. However, what it seems to be helpful for is reducing the size of disc bulges pressing on nerves. Right now, this can only be done through surgery, where the part of the disc pressing on the nerve is excised (discectomy). The problem is that taking out a part of the outer wall of the disc just weakens it, leaving it more prone to failure in the future.

Our Newly Published Study

In this study, we followed 33 patients with the first being treated in 2008 (after we had begun using this novel disc procedure) and the last in 2014. First, there were no serious complications in the group of patients treated, which is a big deal when stem cells that are grown to bigger numbers (culture expanded) are used. Second, there was overall good pain relief. Finally, most of the disc bulges reduced in size on follow-up MRIs. This is important, as if this is confirmed via the phase-2 FDA study, this injection procedure would take the place of hundreds of thousands of surgeries.

The upshot? This procedure seems to be a game changer. We’ll see what happens in the FDA trial, but getting rid of discectomy surgery would be a net positive for everyone.

The Regenexx-C procedure is not approved by the USFDA and is only offered in countries via license where culture-expanded autologous cells are permitted via local regulations. 

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2 thoughts on “Our Latest Research Paper on Disc Stem Cell Injections

  1. Bob

    I had an mri which shows a degenerative disc which is causing sciatica. Would this procedure possibly help? When it first started, pain was fairly substantial but after physical therapy it is quite a bit better. It is always there though. Mostly in my foot.

    Also, what is the Caymen difference in your treatments?

    1. Regenexx Team Post author

      Bob,
      We’d need to do a Candidacy review with your MRI, and ultimately examine you to determine which procedure would be best. This particular procedure would likely help if you had a disc bulge pressing on a nerve. If not, we more commonly treat degenerated discs by treating the nerves, facet joints and ligaments surrounding them. Please see: https://regenexx.com/the-regenexx-procedures/back-surgery-alternative/ and https://regenexx.com/blog/how-to-read-a-low-back-mri-report/ In Grand Cayman we can culture your stem cells to have greater numbers to work with for specific issues which require more stem cells, or use it in treating many joints at once.https://regenexx.com/blog/continuing-advance-orthopedic-regen-med-msc-augmented-prp/ If you’d like to see if you’re for either procedure, please submit the candidate form.

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
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