Bone Marrow Concentrate
Bone marrow concentrate (or “Concentrated Bone Marrow” or “Bone Marrow Aspirate Concentrate” or “BMAC”), is a concentrated form of autologous bone marrow. Bone marrow concentrate is the result of centrifuging bone marrow to obtain a smaller volume which is more highly concentrated with cells and growth factors and therefore more useful as an injectate.
Subscribe to the BlogThe New SIS Fact Finder Paper on Intradiscal Biologics
Is it safe to inject the intervertebral disc with orthobiologics? That’s the topic taken up by the Spinal Intervention Society (SIS) in a recent paper published by their Patient Safety Committee. After reading this paper, I have to say that I agree with some of the caution, but I also recognize that there is a…read more
Is Bone Marrow Concentrate a Shoulder Rotator Cuff Fixer?
This week a Mayo Clinic registry-based study came out suggesting that bone marrow concentrate injections reduced shoulder rotator cuff surgery retear rates. Let’s look at that data in the context of what else has been published and investigate what we know about this treatment in shoulders. Let’s dig in. What Is Bone Marrow Concentrate? Can’t…read more
Is Bone Marrow Concentrate a Stem Cell Therapy?
This has been an interesting few years with regard to the regulations behind using the term “stem cell therapy”. It’s also been an interesting scientific ride as well. Today I’ll review the pure science of whether bone marrow concentrate is a stem cell therapy. I’ll cover the concept that bone marrow concentrate contains stem cells…read more
A Mess of a BMA Study Can Teach Us About Orthobiologic Research
One of the hallmarks of good science is trying to limit variables. That’s what makes clinical research so hard, as making sure that there are only one or two differences between one group of patients and another isn’t always easy. That gets less complex when you’re measuring the lab metrics of something like a bone…read more
Magic Tricks, Electron Microscopy, and Umbilical Cord Tissue
Sleight of hand is a staple in magic tricks. Basically, you get the audience to look over here at an illusion, while the reality behind that illusion happens over there. While this works well on stage, it can also work in research and publications. After all, who really reads and dissects what research papers conclude…read more
PRP vs BMC for Ligament Healing
I love writing about what I experience on a day-to-day basis. A patient recently wrote to me claiming that a prolotherapy physician had told him that PRP injections were clearly superior to Bone Marrow Concentrate for helping ligaments heal. Hence, I figured it was time for a formal deep dive to help patients understand the…read more
CFU-f 101: To Be an Orthobiologics Expert You MUST Learn This
The blind leading the blind is one of my favorite expressions. As one of the founders of this field of interventional orthobiologics, the fact that this statement applies to much of our existing orthobiologics education is concerning to me. Nowhere is this more true than the concept of stem cell dose and CFU-f assays. Hence,…read more
Our Most Recent Publication on Blood Clots, Anticoagulation, and Knee Arthritis BMC Procedures
New medical technology attains a few predictable levels as it’s adopted by more and more physicians. Because we’ve been performing knee bone marrow concentrate procedures for a very long time and collecting registry data on them, we’re well into the final level. As a result, we just published a peer-reviewed research paper on the risk…read more
