Cervical Disc Replacement Complications: Metal Ions

By /

cervical disc replacement complications

We ended the 20th century with the idea that we could cut out parts of a person, like a joint or a disc, and insert metal and achieve great things. Then reality got in the way, in that studies began to show that these metal or plastic or ceramic parts wear down and those particles have to go someplace. This includes into the bloodstream. While this new finding of metal showing up in the blood of patients initially focused on knee and hip replacements, it’s now also showing up in patients who have spinal hardware. The newest data that was just published shows metal ions showing up in the serum of patients who have had spinal-disc-replacement devices inserted.

The Metal Ion Issue

Metal ions are the atoms of metal that are dissolved in fluid, like water or blood. Joint-replacement devices and implants, though incredibly widely used, have had ongoing issues with raising the concentrations of metal ions in serum (the liquid part of blood). Though the medical-device industry has sought to use new designs and materials to mitigate these problems, the problem seems to have gotten worse rather than better.

Why is having metal or other man-made stuff floating around in your blood a problem? Your body has a very slim margin of error where it likes its fluid to allow its cells to function. For example, if the level of acid (pH) in your blood exceeds a certain amount, you can get quite sick. Or if the levels of certain metals, like cobalt or chromium, exceed a certain minute level, systems as wide reaching as skin, to lungs, to nerves can become an issue. The complications from raising blood levels of metals in the body from the use of various orthopedic implants have been reported, and they are as varied as brain changes, genetic instability, device rejection, and even psuedotumors.

Degenerative Disc Disease

Your spine is an incredibly complex and amazing piece of anatomy that houses and protects the spinal cord and spinal nerve roots. It’s also the body’s central support structure, keeping us upright and connecting the different parts of the skeleton to each other. Although it’s made up of a chain of bones called vertebrae, it’s incredibly flexible due to elastic ligaments, stabilizing muscles, and spinal discs. It has many safety mechanisms and backup systems to ensure proper function, but just like in the rest of us, whether it’s gray hairs, wrinkles, or meniscus tears, the shock absorbers of our spine, called discs, are affected by wear and tear and changes due to the aging process. These changes in a spinal disc can cause it to no longer hold on to water effectively, and as a result it becomes a less effective shock absorber. The disc can also lose height and collapse. But unlike gray hair or meniscus tears due to normal aging, loss of height in a disc does cause problems. The disc becomes unstable and moves back and forth on the disc above and below, which can injure the facet joints and cause arthritis. In response to this excessive motion, your body attempts to stabilize the vertebrae by producing bone spurs, causing a narrowing of the space for the spinal nerves to go through, called stenosis. If enough extra bone is deposited, the bone spur can irritate the spinal nerves, which can lead to neck, back, arm/hand, or leg/foot symptoms.

What Are the Traditional Orthopedic Solutions?

Rather than addressing and repairing any of the failing parts described in the video above that cause instability and resulting bone spurs and so on, in degenerative disc disease, the traditional structural orthopedic paradigm is to fuse the disc solid or to replace it with a metal implant. In a cervical fusion, the disc is removed, a spacer is inserted, and then a rod or plate is used to bolt together the vertebrae above and below. In cervical disc replacement, the disc is removed and then replaced with an artificial disc that is not bolted to the vertebrae above and below. The advantage of the disc replacement is that it still allows some movement while restoring disc height.

The Cervical Disc Replacement Metal Ion Study

The disc-replacement device studied in the new research is made of a titanium alloy and titanium carbon composite and called the PRESTIGE LP Cervical Disc System. The new study sought to compare the blood metal ion concentrations of patients who had these devices implanted with those of other titanium joint replacements and fixation devices. The metal ion concentration was tested preoperatively in 30 patients who had never had any type of metal implant and then tested at regular time points, beginning at one month and lasting throughout seven years post surgery. The results showed that the metal ion concentrations in the participants’ blood were significantly higher at all time points after the cervical disc replacement than they had been before the surgery.

This finding adds a significant new, but not unexpected, entry to the cervical disc replacement complications profile. Load is still passed along to the vertebrae above and below, but, importantly, when something is articulated, meaning two segments are connected by a movable joint, whether it is a hip- or knee-replacement device or an articulated cervical disc replacement system, wear and debris occurs. The difference is, in your natural joints, the wear and tear does not include toxic metal ions.

Considering the Cervical Disc Replacement Complications, Are There Better Solutions?

Rather than removing discs and replacing them with hardware and then dealing with issues like adjacent segment disease and cervical disc replacement complications, like metal ions, nerve issues, and other complications, treating the ligaments and muscles meant to stabilize the vertebrae with precise image-guided injections of your own platelets or stem cells works very well in many cases.

The upshot? The medical-care system continues to promote the idea that you can cut out body parts and insert metal or plastic at will. Why? It’s a huge and big-bucks industry worth in the aggregate hundreds of billions of dollars. However, there is a problem called wear debris, and no matter how you design these implants, wear will occur. In addition, if you continue to advertise these devices to be used in younger and healthier patients who are more active, more wear will happen. Hence, more wear equals more particles, and more particles equals more bad stuff floating around in patients!

Get health and wellness information from a trusted source.

By submitting the form, you are agreeing that you read and consent to our Privacy Policy. We may also contact you via email, phone, and other electronic means to communicate information about our products and services. We do not sell, or share your information to third party vendors.

Leave a Reply

Your email address will not be published. Required fields are marked *

5 thoughts on “Cervical Disc Replacement Complications: Metal Ions

  1. Tom

    I remember an article about the best form of regenerative PRP-treatments to heal damaged cartilage and bones in your blog. Could you please help me and show me where to find this article?
    Thank you in advance

    1. Regenexx Team Post author

      These might be what you are looking for. If not, you can use the search function on the website. http://www.regenexx.com https://regenexx.com/blog/what-is-prp/ and https://regenexx.com/blog/prp-didnt-work/ Generally speaking PRP is best for mild damage, stem cells are usually needed for more severe damage.

  2. Tom

    Great, Thank you

  3. Bonnie LaMalfa

    I’ve had C-5/6, 6/7, 7/8 all replaced. The first two used cadaver bone and the last time they put hardware in. How can I determine if I have toxic ions in my blood and can anything be done about it at this point?

    1. Regenexx Team Post author

      Quest Diagnostics has a blood test for Titanium levels, but unfortunately, Fusion is irreversible.

Is Regenexx Right For You?

Request a free Regenexx Info Packet


Learn about the #1 Stem Cell & Platelet Procedures for treating arthritis, common joint injuries & spine pain.

Join a Webinar


Get fresh updates and insights from Regenexx delivered straight to your inbox.

Subscribe to the Blog


9035 Wadsworth Pkwy #1000
Westminster, CO 80021


Copyright © Regenexx 2020. All rights reserved. | Privacy Policy

*DISCLAIMER: Like all medical procedures, Regenexx® Procedures have a success and failure rate. Patient reviews and testimonials on this site should not be interpreted as a statement on the effectiveness of our treatments for anyone else.

Providers listed on the Regenexx website are for informational purposes only and are not a recommendation from Regenexx for a specific provider or a guarantee of the outcome of any treatment you receive.