Regenexx-SD Knee Stem Cell Procedure Data for 2013

by Chris Centeno, MD /

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knee stem cell procedureWho has the most knee stem cell procedure data? All this week I have been publishing various analysis by our registry and bio stats teams. These analyses are possible because of the massive numbers that have been accumulating for years in our registry. Prior to this year, the numbers weren’t yet big enough to allow the data to be sliced and diced multiple ways so that important questions could be answered. Today I’d like to begin publishing the larger data set of patients who underwent the Regenexx-SD same day stem cell procedure for knee arthritis. More publications will follow of this same group as well as on other joints.

Since the early 2012 version of this infographic we’ve gone from just under 200 same day knee cases being tracked to now more than 500 (this infographic has a link to last year’s). Just as last year, these patients are about 2 to 1 men, older in their 50’s, and slightly over weight. The percentage improvements that were only reported out to 18 months last year are now reported to 3 years. Also note that it’s very comforting how the overall reports in the 6-18 month range have stayed stable in the mid-50s, despite the number of patients reporting more than doubling. The continued improvements at 2 and 3 years are consistent with what we have seen in other procedures we have tracked. While the 2 year number of patients reporting is solid, I would caution anyone with hanging their hat on the three year reports yet until the number of patients reporting at that time frame gets bigger next year.

This year, instead of reporting any improvement from baseline (0-100%), I’ve reported on the percentage of all patients at each time point who had more than 25% improvement. I chose this cut off as I feel from examining and talking to hundreds of orthopedic stem cell patients that unless they report that they are at least 25% better, they don’t usually consider their progress as clinically significant.

What this data isn’t and how not to interpret it. This is data from our advanced treatment registry. It isn’t the same as a drug company style randomized controlled trial. While we’re recruiting for several of those including one beginning in Chicago for knee arthritis, this is important to note. In addition, when I report the mean improvement at a time point, for example 53%; this means that if all of the patients who reported at that time were averaged, their mean report was 53% better. It doesn’t mean that everyone should expect to feel 53% better by that time point. Finally, this data only applies to our proprietary three part stem cell procedure and doesn’t apply to all stem cell procedures being performed today for knee arthritis.

The upshot? Nobody has reported on more orthopedic stem cell data than Regenexx, period. This most recent knee data set tracked more than 500 knee patients for 3+ years and doesn’t include other body areas like hip, ankle, shoulder, etc…, that’s coming. This data set also doesn’t include cultured patients (just same day), that’s has already been published in the peer reviewed literature and an update is in the works. Like I have been saying for the last week, there’s the Regenexx procedure and then there’s stem cell guesswork. As always, the link to the new knee stem cell infographic is here or you can click on the thumbnail above.

Chris Centeno, MD

Regenexx Founder

Chris Centeno, MD is a specialist in regenerative medicine and the new field of Interventional Orthopedics. Centeno pioneered orthopedic stem cell procedures in 2005 and is responsible for a large amount of the published research on stem cell use for orthopedic applications.
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Regenerative procedures are commonly used to treat musculoskelatal trauma, overuse injuries, and degenerative issues, including failed surgeries.
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