More Bad NSAID News: Male Infertility

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nsaids and male infertilityNSAIDs are the side-effect laden drugs that America loves. The average thirty- to fifty-something soon realizes that if he or she pops a few Motrin, it’s possible to exercise with less pain, so the addition begins. Before long, the patient notices that he or she can’t function without the drugs. Despite this widespread use, NSAID drugs are some of the most dangerous you can buy and consume. Now a new reason to avoid the drugs has been reported: they can make men infertile!

Before I review the newest study on NSAIDs and male infertility, let me define NSAIDs and explain what some of the research has revealed to date.

What Are NSAIDs?

NSAIDs are nonsteroidal anti-inflammatory drugs, and if you take a peek in your medicine cabinet, there’s a good chance you have a bottle. Why? Because many of the most common over-the-counter painkillers are NSAIDs: Advil, Motrin, Aleve, and so on. Generic names include ibuprofen, aspirin, and naproxen, and there are also prescription versions as well. While they are powerful drugs known not just for their ability to knock out pain, their key feature is also being able to tackle inflammation. Many people, however, will pop an NSAID for a simple headache, when they only need to relieve pain, not inflammation. In this case, more is not better; it’s just more dangerous.

Additionally, even if you do have acute inflammation, due to a sprained ankle for example, inflammation is beneficial as it is your body’s way of healing itself. So stifling that process with an NSAID disrupts the body’s ability to heal itself. Chronic inflammation is a whole different issue but still one where we typically recommend avoiding NSAIDs.

If you follow this blog, you know NSAIDs make the rounds every few months, and you know I’m not fond of them. Why? Where do I start?…

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Study After Study Giving Us Reasons to Toss the NSAIDs

The research hasn’t been kind to NSAIDs in recent years, and for good reason: they are dangerous drugs linked to a long list of disturbing and even deadly side effects.

If you are taking NSAIDs for arthritis pain and inflammation, this may be progressing your arthritis damage in your joint. The potential mechanism for this may be the effect of certain NSAIDs on cartilage due to their interaction with stem cells. It seems these NSAIDs may prevent healing by encouraging stem cells to produce abnormal cartilage.

There’s also, of course, the well-known risks that are required to be printed right on the NSAID medication labels: gastrointestinal bleeding, heart attacks, and strokes that could lead to sudden death. NSAID warnings for these deadly risks have been issued by both the American Heart Association and the FDA. While the NSAID label warnings suggest the risk of heart attack is with long-term or excessive use, one study found that NSAID use for only one week can increase the risk of heart attack by as much as 50%!

Kidney damage is another well-known risk of NSAIDs. Researchers attempting to answer their hypothesis that long-distance runners who rely on NSAIDs have no increased risk of kidney damage actually disproved their theory, finding that there was an 18% increase in kidney damage in runners who took NSAIDs before and after their race. In this case, ibuprofen fared the worst as kidney damage was more severe in runners who took this NSAID.

This leads us to the new study that reveals disturbing findings on ibuprofen use by young (age 18–35) males.

NSAIDs and Male Infertility? The Ibuprofen Study

The new study consisted of 31 men who were randomly divided into two groups. One group (the test group) took 1200 milligrams of ibuprofen per day, which is the recommended maximum daily dosage, for two weeks. The second group (the control group) took a placebo.

The results? A hormonal imbalance occurred only in the ibuprofen group that researchers attributed to a correlation between the circulating ibuprofen and the luteinizing hormone produced by the pituitary gland. Luteinizing hormone in males stimulates the production of testosterone. This imbalance caused a decrease in testosterone, creating a condition called compensated hypogonadism, which is known to impair male fertility. Incidentally, it is also associated with an increased risk of heart failure and stroke. Their conclusion? Ibuprofen induces compensated hypogonadism. With this comes the increased risk of male infertility.

The upshot? Please get off of these drugs as a new year’s resolution. Get your pain problems diagnosed and fixed rather than continuing to pop drugs that may seriously injure you!

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This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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9 thoughts on “More Bad NSAID News: Male Infertility

  1. Shirley D

    I have been in pain since I have been about 25 years old I have taken dozens of bottles of aspirin, ansaids, and prescription drugs my doctor was a pill pusher when I ask for test he gave me pill until I was a bloody mess and ended up with colon cancer twice now I just live with it and take nothing most of the time I stoped eating sugar of all kinds and no white flour now I am fighting awful pain in my lower back and it runs down my left leg into my ankle I am for a loss as what to do to stop my pain Oh and I have also gone thru the shots in the spine.
    Do you think that stem cell would help me?

    1. Chris Centeno Post author

      I don’t have enough information to answer that question. We have a candidacy review process to determine if this is a good fit.

  2. oshen

    getting hip replaced…
    can and could stem cells aid this ?

    1. Regenexx Team

      If your hip is a Candidate for stem cells, best to avoid the surgery altogether. If not, your own bone marrow stem cells added to surgery may improve healing. Please see: and

  3. Fred R Schneider

    I had a wonderful hip replacement two months ago and was out of the hospital the very next day and walking without a cane and driving within 7 days with the anterior approach- the hip was completely shot and the VA had given me the run around until VA Choice came in to play. Great job by Dr. Stryker and as the St. Mary’s hospital so great people helping also.
    Have taken Aleve for years and no real problems (get blood tested every year) and it has helped with inflamtion and arthritis. I have tired all kinds of things including hemp and none of them work. Someone needs to find out how the barometer affects the body and a cure to counter that painful affect in my humble opine.

    1. Regenexx Team

      Great to hear you’re doing well! The Anterior approach tends to have better results. Aside from the other NSAID risk factors, Aleve, which is Naprosyn, causes your body to produce abnormal cartilage, so it is a catch 22. Patients take it to deal with the pain of arthritis, but it’s makes the arthritis worse. Please see:

  4. Rod Sellers

    Quitting NSAIDs , Voltarin particularly at Regenexx,s request was very very difficult, after years of depending on the drug for bad knees. Now after close to 10 months of not using any NSAIDs I’m doing well. The natural anti inflammatory products took a long time to start helping but finally are working. The first 3 months off the NSAIDs were tough, my entire body hurt. But it can be done. I had stem cell treatment in the Cayman Clinic and at this point I am improving slowly and steady, I hope the progress continues. I’m now skiing 3 or 4 mornings a week, taking it easy, no bumps or hard pack just easy cruising. So far so good. Thank you Regeenex
    Rod Sellers

    1. Regenexx Team

      Wonderful to hear you’re doing well. Thanks for sharing your truly inspiring story!

  5. Reggie Edwards

    Thanks for the information on NSAIDS. My Dr. told me on my last visit, do not take any NSAIDS and I later wondered why. Now I know, thanks.

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