Bone Marrow Concentrate
Bone marrow concentrate (or “Concentrated Bone Marrow” or “Bone Marrow Aspirate Concentrate” or “BMAC”), is a concentrated form of autologous bone marrow. Bone marrow concentrate is the result of centrifuging bone marrow to obtain a smaller volume which is more highly concentrated with cells and growth factors and therefore more useful as an injectate.
Subscribe to the BlogCan You Easily Determine MSC Content of BMC at the Bedside?
Dose is a key metric in medicine. However, dosing cells isn’t used in most of orthobiologics. However, is that about to change? Will it be possible to get a dose of stem cells at the bedside when using BMC or Mfat? Let’s dig in. Dose Matters Determining the stem cell content of Bone Marrow Concentrate…read more
Bone Marrow Concentrate and PRP: Is Keeling et al Just More Carefully Selected Misinformation?
I’ve written many times that we have an academic orthobiologics problem. There’s also a problem with orthobiologics and orthopedic surgeons. I’ll explore this today through a recent review article published in the American Journal of Sports Medicine that concluded that Bone Marrow Concentrate was no better than PRP, but seems to have carefully selected research…read more
Regenexx Snags Another Patent
Regenexx has been granted dozens of patents throughout the years. This week we received a Korean patent on devices that create platelet lysate for clinical use. Let’s dig in. What is Platelet Lysate (PL)? Platelet lysate is a key technology that Regenexx developed for clinical use way back in 2005. Platelets have growth factors and…read more
Bone Marrow Concentrate and Non-union Fractures
The good news is that fractures almost always heal in a few months, but the bad news is sometimes they don’t. When that happens, that’s called a “non-union” which can be a mess requiring additional surgery. However, we’ve known for decades that bone marrow concentrate has fracture healing capabilities. Let’s dig in. What Happens When…read more
What’s the Difference between Prolotherapy, PRP, and Bone Marrow Concentrate?
While today’s topic may seem very simple, I get this question so often that it’s an important one to review now and again. Prolotherapy, PRP, and Bone Marrow Concentrate collectively make up about 70% of all Regen Med treatments offered in Orthopedic care. Hence, understanding the differences between them is critical. Let’s dive in. Interventional…read more
What a New Bone Marrow Knee Study Can Teach Us About QA
QA is a term that you hear more often in industries like manufacturing or engineering, not in medicine. However, the bone marrow concentrate procedure for knee arthritis has so many moving parts that QA is key. So today we’ll review a new research paper and also learn how they failed on several key QA metrics.…read more
Welcome to the Hip Osteonecrosis BMC Club Yale!
One of the trends of the last 5 years is seeing more and more universities add the use of PRP and Bone Marrow Concentrate to their day-to-day patient offerings. One of those treatments that we’ve been using for more than a decade is a Bone Marrow Concentrate injection to treat Osteonecrosis of the hip. Now…read more
Is Academia Leading or Trailing Private Practice in the Field of Orthobiologics?
In many areas of medicine, you go to an academic Medical Center if you have a rare condition. However, in orthobiologics, it’s been the opposite in that there is more accumulated experience and published data in private practices. This morning I’ll review why that is and how academia stacks up. Let’s dig in. Academia and…read more
